Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

Wanchao Yin; Chunyou Mao; Xiaodong Luan; Dan-Dan Shen; Qingya Shen; Haixia Su; Xiaoxi Wang; Fulai Zhou; Wenfeng Zhao; Minqi Gao; Shenghai Chang; Yuan-Chao Xie; Guanghui Tian; He-Wei Jiang; Sheng-Ce Tao; Jingshan Shen; Yi Jiang; Hualiang Jiang; Yechun Xu; Shuyang Zhang; Yan Zhang; H. Eric Xu

doi:10.1101/2020.04.08.032763

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Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

View ORCID ProfileWanchao Yin, Chunyou Mao, Xiaodong Luan, Dan-Dan Shen, Qingya Shen, Haixia Su, Xiaoxi Wang, Fulai Zhou, Wenfeng Zhao, Minqi Gao, Shenghai Chang, Yuan-Chao Xie, Guanghui Tian, He-Wei Jiang, Sheng-Ce Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, View ORCID ProfileYechun Xu, Shuyang Zhang, Yan Zhang, H. Eric Xu

doi: https://doi.org/10.1101/2020.04.08.032763

Wanchao Yin

1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

2Department of Biophysics, and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China

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ORCID record for Wanchao Yin

Chunyou Mao

2Department of Biophysics, and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China

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Xiaodong Luan

3School of Medicine, Tsinghua University, Haidian District, Beijing, China

4Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China

5Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China

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Dan-Dan Shen

2Department of Biophysics, and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China

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Qingya Shen

2Department of Biophysics, and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China

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Haixia Su

1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

6University of Chinese Academy of Sciences, Beijing 100049, China

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Xiaoxi Wang

1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

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Fulai Zhou

1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

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Wenfeng Zhao

1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

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Minqi Gao

7Wuxi Biortus Biosciences Co. Ltd., 6 Dongsheng West Road, Jiangyin 214437, China

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Shenghai Chang

8Center of Cryo-Electron Microscopy, Zhejiang University School of Medicine, Hangzhou 310058, China

9Center of Diagnostic Electron Microscopy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China

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Yuan-Chao Xie

1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

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Guanghui Tian

1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

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He-Wei Jiang

10Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China

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Sheng-Ce Tao

10Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China

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Jingshan Shen

1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

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Yi Jiang

1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

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Hualiang Jiang

1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

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Yechun Xu

1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

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ORCID record for Yechun Xu
For correspondence: eric.xu@simm.ac.cn zhang_yan@zju.edu.cn shuyangzhang103@nrdrs.org ycxu@simm.ac.cn

Shuyang Zhang

4Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China

5Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China

3School of Medicine, Tsinghua University, Haidian District, Beijing, China

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For correspondence: eric.xu@simm.ac.cn zhang_yan@zju.edu.cn shuyangzhang103@nrdrs.org ycxu@simm.ac.cn

Yan Zhang

2Department of Biophysics, and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China

11Key Laboratory of Immunity and Inflammatory Diseases of Zhejiang Province, Hangzhou 310058, China

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For correspondence: eric.xu@simm.ac.cn zhang_yan@zju.edu.cn shuyangzhang103@nrdrs.org ycxu@simm.ac.cn

H. Eric Xu

1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

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For correspondence: eric.xu@simm.ac.cn zhang_yan@zju.edu.cn shuyangzhang103@nrdrs.org ycxu@simm.ac.cn

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PDB for the apo structure[supplements/032763_file03.pdb]
PDB for the Remdesivir structure[supplements/032763_file04.pdb]
Map for the apo structure[supplements/032763_file05.zip]
Map for the Remdesivir bound structure[supplements/032763_file06.zip]

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Posted April 10, 2020.

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Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

Wanchao Yin, Chunyou Mao, Xiaodong Luan, Dan-Dan Shen, Qingya Shen, Haixia Su, Xiaoxi Wang, Fulai Zhou, Wenfeng Zhao, Minqi Gao, Shenghai Chang, Yuan-Chao Xie, Guanghui Tian, He-Wei Jiang, Sheng-Ce Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu, Shuyang Zhang, Yan Zhang, H. Eric Xu

bioRxiv 2020.04.08.032763; doi: https://doi.org/10.1101/2020.04.08.032763

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