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Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract

View ORCID ProfileJaewon J. Lee, View ORCID ProfileScott Kopetz, View ORCID ProfileEduardo Vilar, View ORCID ProfileJohn Paul Shen, View ORCID ProfileKen Chen, View ORCID ProfileAnirban Maitra
doi: https://doi.org/10.1101/2020.04.08.033001
Jaewon J. Lee
1Department of Translational Molecular Pathology
2Sheikh Ahmed Center for Pancreatic Cancer Research
3Department of Surgical Oncology
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Scott Kopetz
4Department of Gastrointestinal Medical Oncology
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Eduardo Vilar
4Department of Gastrointestinal Medical Oncology
5Department of Clinical Cancer Prevention
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John Paul Shen
4Department of Gastrointestinal Medical Oncology
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Ken Chen
6Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
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Anirban Maitra
1Department of Translational Molecular Pathology
2Sheikh Ahmed Center for Pancreatic Cancer Research
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  • For correspondence: amaitra@mdanderson.org
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Abstract

COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread throughout the world and was declared a pandemic by the World Health Organization, thus leading to a rapid surge in the efforts to understand the mechanisms of transmission, methods of prevention, and potential therapies. While COVID-19 frequently manifests as a respiratory infection,1 there is evidence for infection of the gastrointestinal (GI) tract1–4 with documented viral RNA shedding in the stool of infected patients.2,4 In this study, we aimed to investigate the expression of ACE2 and TMPRSS2, which are required for SARS-CoV-2 entry into mammalian cells,5 from single-cell RNA sequencing (scRNA-seq) datasets of five different parts of the GI tract: esophagus, stomach, pancreas, small intestine, and colon/rectum.

Competing Interest Statement

A.M. receives royalties for a pancreatic cancer biomarker test from Cosmos Wisdom Biotechnology, and this financial relationship is managed and monitored by the UTMDACC Conflict of Interest Committee. A.M. is also listed as an inventor on a patent that has been licensed by Johns Hopkins University to Thrive Earlier Detection. E.V. has a consulting and advisory role with Janssen research and Development. The remaining authors disclose no conflicts.

Footnotes

  • Conflict of Interest: A.M. receives royalties for a pancreatic cancer biomarker test from Cosmos Wisdom Biotechnology, and this financial relationship is managed and monitored by the UTMDACC Conflict of Interest Committee. A.M. is also listed as an inventor on a patent that has been licensed by Johns Hopkins University to Thrive Earlier Detection. E.V. has a consulting and advisory role with Janssen research and Development. The remaining authors disclose no conflicts.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted April 09, 2020.
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Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract
Jaewon J. Lee, Scott Kopetz, Eduardo Vilar, John Paul Shen, Ken Chen, Anirban Maitra
bioRxiv 2020.04.08.033001; doi: https://doi.org/10.1101/2020.04.08.033001
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Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract
Jaewon J. Lee, Scott Kopetz, Eduardo Vilar, John Paul Shen, Ken Chen, Anirban Maitra
bioRxiv 2020.04.08.033001; doi: https://doi.org/10.1101/2020.04.08.033001

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