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Environmental enrichment alleviates the deleterious effects of stress in experimental autoimmune encephalomyelitis

Antoine Philippe Fournier, Erwan Baudron, Isabelle Wagnon, Philippe Aubert, Denis Vivien, Michel Neunlist, Isabelle Bardou, View ORCID ProfileFabian Docagne
doi: https://doi.org/10.1101/2020.04.10.033662
Antoine Philippe Fournier
1Normandie Univ, Unicaen, Inserm, Physiopathology and imaging of neurological disorders (PhIND), Caen, France
2Université de Montréal, Faculté de Médecine, Département de Neuroscience, Montréal, Canada
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Erwan Baudron
1Normandie Univ, Unicaen, Inserm, Physiopathology and imaging of neurological disorders (PhIND), Caen, France
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Isabelle Wagnon
1Normandie Univ, Unicaen, Inserm, Physiopathology and imaging of neurological disorders (PhIND), Caen, France
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Philippe Aubert
3Université de Nantes, Inserm, The enteric nervous system in gut and brain disorders, Nantes, France
4Institut des Maladies de l’Appareil Digestif, Nantes, France
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Denis Vivien
1Normandie Univ, Unicaen, Inserm, Physiopathology and imaging of neurological disorders (PhIND), Caen, France
5Department of clinical research, CHU Côte de Nacre, Caen, France
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Michel Neunlist
3Université de Nantes, Inserm, The enteric nervous system in gut and brain disorders, Nantes, France
4Institut des Maladies de l’Appareil Digestif, Nantes, France
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Isabelle Bardou
1Normandie Univ, Unicaen, Inserm, Physiopathology and imaging of neurological disorders (PhIND), Caen, France
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Fabian Docagne
1Normandie Univ, Unicaen, Inserm, Physiopathology and imaging of neurological disorders (PhIND), Caen, France
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  • ORCID record for Fabian Docagne
  • For correspondence: docagne@cyceron.fr
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ABSTRACT

Clinical observations support the hypothesis that stressful events increase relapse occurrence in multiple sclerosis patients, while stress-reduction strategies can modulate this effect. However, a direct cause-effect relationship between stress level and relapse cannot be firmly established from these data. The purpose of this work was to address whether modulation of stress could interfere with symptom relapse in an animal model of multiple sclerosis with relapsing-remitting course. We report that repeated acute stress induced a twofold increase in relapse incidence in experimental autoimmune encephalomyelitis. On the other hand, environmental enrichment reduced relapse incidence and severity, and reversed the effects of repeated acute stress. These data provide the platform for further studies on the biological processes that link stress and multiple sclerosis relapses in a suitable animal model.

Competing Interest Statement

The authors have declared no competing interest.

  • Abbreviations

    MS
    Multiple sclerosis
    EAE
    Experimental autoimmune encephalomyelitis
    RR-EAE
    Relapsing-Remitting EAE
    PLP
    Proteolipid protein
    CFA
    Complete Freund adjuvant
    WAS
    Water avoidance stress
    EE
    Enriched Environment
    STD
    Standard Environment
  • Copyright 
    The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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    Posted April 11, 2020.
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    Environmental enrichment alleviates the deleterious effects of stress in experimental autoimmune encephalomyelitis
    Antoine Philippe Fournier, Erwan Baudron, Isabelle Wagnon, Philippe Aubert, Denis Vivien, Michel Neunlist, Isabelle Bardou, Fabian Docagne
    bioRxiv 2020.04.10.033662; doi: https://doi.org/10.1101/2020.04.10.033662
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    Environmental enrichment alleviates the deleterious effects of stress in experimental autoimmune encephalomyelitis
    Antoine Philippe Fournier, Erwan Baudron, Isabelle Wagnon, Philippe Aubert, Denis Vivien, Michel Neunlist, Isabelle Bardou, Fabian Docagne
    bioRxiv 2020.04.10.033662; doi: https://doi.org/10.1101/2020.04.10.033662

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