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Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro

Hongbo Liu, Fei Ye, Qi Sun, Hao Liang, Chunmei Li, Roujian Lu, Baoying Huang, Wenjie Tan, View ORCID ProfileLuhua Lai
doi: https://doi.org/10.1101/2020.04.10.035824
Hongbo Liu
1BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
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Fei Ye
2MHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China
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Qi Sun
1BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
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Hao Liang
1BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
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Chunmei Li
3Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
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Roujian Lu
2MHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China
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Baoying Huang
2MHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China
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Wenjie Tan
2MHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China
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  • For correspondence: lhlai@pku.edu.cn tanwj28@163.com
Luhua Lai
1BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
3Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
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  • ORCID record for Luhua Lai
  • For correspondence: lhlai@pku.edu.cn tanwj28@163.com
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Article Information

doi 
https://doi.org/10.1101/2020.04.10.035824
History 
  • April 12, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Hongbo Liu1,#,
  2. Fei Ye2,#,
  3. Qi Sun1,#,
  4. Hao Liang1,#,
  5. Chunmei Li3,#,
  6. Roujian Lu2,
  7. Baoying Huang2,
  8. Wenjie Tan2,* and
  9. Luhua Lai1,3,*
  1. 1BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
  2. 2MHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China
  3. 3Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
  1. ↵*Corresponding authors: Luhua Lai, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China, Email: lhlai{at}pku.edu.cn, Wenjie Tan, NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China, Email: tanwj28{at}163.com
  1. ↵# These authors contribute equally.

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Posted April 12, 2020.
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Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro
Hongbo Liu, Fei Ye, Qi Sun, Hao Liang, Chunmei Li, Roujian Lu, Baoying Huang, Wenjie Tan, Luhua Lai
bioRxiv 2020.04.10.035824; doi: https://doi.org/10.1101/2020.04.10.035824
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Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro
Hongbo Liu, Fei Ye, Qi Sun, Hao Liang, Chunmei Li, Roujian Lu, Baoying Huang, Wenjie Tan, Luhua Lai
bioRxiv 2020.04.10.035824; doi: https://doi.org/10.1101/2020.04.10.035824

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