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The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement

View ORCID ProfileBrian D. Quinlan, Huihui Mou, Lizhou Zhang, Yan Guo, Wenhui He, Amrita Ojha, Mark S. Parcells, Guangxiang Luo, Wenhui Li, Guocai Zhong, View ORCID ProfileHyeryun Choe, View ORCID ProfileMichael Farzan
doi: https://doi.org/10.1101/2020.04.10.036418
Brian D. Quinlan
1Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA
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  • ORCID record for Brian D. Quinlan
Huihui Mou
1Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA
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Lizhou Zhang
1Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA
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Yan Guo
1Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA
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Wenhui He
1Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA
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Amrita Ojha
1Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA
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Mark S. Parcells
2Department of Animal and Food Sciences, University of Delaware, Newark, DE 19716, USA
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Guangxiang Luo
3Department of Microbiology, University of Alabama at Birmingham School Of Medicine, Birmingham, AL 35294, USA
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Wenhui Li
4National Institute of Biological Sciences, Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China
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Guocai Zhong
5Scripps Research | SZBL Chemical Biology Institute, Shenzhen Bay Laboratory (SZBL), Shenzhen, China
6School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China
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Hyeryun Choe
1Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA
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  • For correspondence: hchoe@scripps.edu mfarzan@scripps.edu
Michael Farzan
1Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA
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  • ORCID record for Michael Farzan
  • For correspondence: hchoe@scripps.edu mfarzan@scripps.edu
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Article Information

doi 
https://doi.org/10.1101/2020.04.10.036418
History 
  • April 12, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Brian D. Quinlan1,7,
  2. Huihui Mou1,7,
  3. Lizhou Zhang1,7,
  4. Yan Guo1,7,
  5. Wenhui He1,
  6. Amrita Ojha1,
  7. Mark S. Parcells2,
  8. Guangxiang Luo3,
  9. Wenhui Li4,
  10. Guocai Zhong5,6,
  11. Hyeryun Choe1,* and
  12. Michael Farzan1,*
  1. 1Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA
  2. 2Department of Animal and Food Sciences, University of Delaware, Newark, DE 19716, USA
  3. 3Department of Microbiology, University of Alabama at Birmingham School Of Medicine, Birmingham, AL 35294, USA
  4. 4National Institute of Biological Sciences, Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China
  5. 5Scripps Research | SZBL Chemical Biology Institute, Shenzhen Bay Laboratory (SZBL), Shenzhen, China
  6. 6School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China
  1. ↵*Correspondence: hchoe{at}scripps.edu (H.C.); mfarzan{at}scripps.edu (M.F.)
  1. ↵7 These authors contributed equally

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Posted April 12, 2020.
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The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement
Brian D. Quinlan, Huihui Mou, Lizhou Zhang, Yan Guo, Wenhui He, Amrita Ojha, Mark S. Parcells, Guangxiang Luo, Wenhui Li, Guocai Zhong, Hyeryun Choe, Michael Farzan
bioRxiv 2020.04.10.036418; doi: https://doi.org/10.1101/2020.04.10.036418
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The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement
Brian D. Quinlan, Huihui Mou, Lizhou Zhang, Yan Guo, Wenhui He, Amrita Ojha, Mark S. Parcells, Guangxiang Luo, Wenhui Li, Guocai Zhong, Hyeryun Choe, Michael Farzan
bioRxiv 2020.04.10.036418; doi: https://doi.org/10.1101/2020.04.10.036418

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