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Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics
Longlong Si, Haiqing Bai, Melissa Rodas, Wuji Cao, Crystal Yuri Oh, Amanda Jiang, Rasmus Moller, Daisy Hoagland, Kohei Oishi, Shu Horiuchi, Skyler Uhl, Daniel Blanco-Melo, Randy A. Albrecht, Wen-Chun Liu, Tristan Jordan, Benjamin E. Nilsson-Payant, James Logue, Robert Haupt, Marisa McGrath, Stuart Weston, Atiq Nurani, Seong Min Kim, Danni Y. Zhu, Kambez H. Benam, Girija Goyal, Sarah E. Gilpin, Rachelle Prantil-Baun, Rani K. Powers, Kenneth Carlson, Matthew Frieman, Benjamin R. tenOever, Donald E. Ingber
doi: https://doi.org/10.1101/2020.04.13.039917
Longlong Si
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Haiqing Bai
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Melissa Rodas
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Wuji Cao
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Crystal Yuri Oh
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Amanda Jiang
3Vascular Biology Program and Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA
Rasmus Moller
4Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Daisy Hoagland
4Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Kohei Oishi
4Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Shu Horiuchi
4Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Skyler Uhl
4Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Daniel Blanco-Melo
4Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Randy A. Albrecht
4Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
5Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Wen-Chun Liu
4Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
5Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Tristan Jordan
4Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Benjamin E. Nilsson-Payant
4Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
James Logue
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Robert Haupt
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Marisa McGrath
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Stuart Weston
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Atiq Nurani
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Seong Min Kim
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Danni Y. Zhu
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Kambez H. Benam
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Girija Goyal
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Sarah E. Gilpin
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Rachelle Prantil-Baun
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Rani K. Powers
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Kenneth Carlson
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Matthew Frieman
6Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Benjamin R. tenOever
4Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Donald E. Ingber
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
2Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02139, USA
3Vascular Biology Program and Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA
Article usage
Posted August 19, 2020.
Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics
Longlong Si, Haiqing Bai, Melissa Rodas, Wuji Cao, Crystal Yuri Oh, Amanda Jiang, Rasmus Moller, Daisy Hoagland, Kohei Oishi, Shu Horiuchi, Skyler Uhl, Daniel Blanco-Melo, Randy A. Albrecht, Wen-Chun Liu, Tristan Jordan, Benjamin E. Nilsson-Payant, James Logue, Robert Haupt, Marisa McGrath, Stuart Weston, Atiq Nurani, Seong Min Kim, Danni Y. Zhu, Kambez H. Benam, Girija Goyal, Sarah E. Gilpin, Rachelle Prantil-Baun, Rani K. Powers, Kenneth Carlson, Matthew Frieman, Benjamin R. tenOever, Donald E. Ingber
bioRxiv 2020.04.13.039917; doi: https://doi.org/10.1101/2020.04.13.039917
Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics
Longlong Si, Haiqing Bai, Melissa Rodas, Wuji Cao, Crystal Yuri Oh, Amanda Jiang, Rasmus Moller, Daisy Hoagland, Kohei Oishi, Shu Horiuchi, Skyler Uhl, Daniel Blanco-Melo, Randy A. Albrecht, Wen-Chun Liu, Tristan Jordan, Benjamin E. Nilsson-Payant, James Logue, Robert Haupt, Marisa McGrath, Stuart Weston, Atiq Nurani, Seong Min Kim, Danni Y. Zhu, Kambez H. Benam, Girija Goyal, Sarah E. Gilpin, Rachelle Prantil-Baun, Rani K. Powers, Kenneth Carlson, Matthew Frieman, Benjamin R. tenOever, Donald E. Ingber
bioRxiv 2020.04.13.039917; doi: https://doi.org/10.1101/2020.04.13.039917
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