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Subtypes of functional connectivity associate robustly with ASD diagnosis

View ORCID ProfileSebastian G. Urchs, Angela Tam, Pierre Orban, View ORCID ProfileClara Moreau, Yassine Benhajali, Hien Duy Nguyen, Alan C. Evans, Pierre Bellec
doi: https://doi.org/10.1101/2020.04.14.040576
Sebastian G. Urchs
1Montreal Neurological Institute and Hospital, McGill University, 3801 Rue de l’Université, QC H3A 2B4, Montreal, Canada
2Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, 4565 Queen Mary Rd, QC H3W 1W5, Montreal, Canada
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  • ORCID record for Sebastian G. Urchs
  • For correspondence: sebastian.urchs@mail.mcgill.ca pierre.bellec@criugm.qc.ca
Angela Tam
2Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, 4565 Queen Mary Rd, QC H3W 1W5, Montreal, Canada
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Pierre Orban
3Centre de Recherche de l’Institut Universitaire en Santé Mentale de Montréal, 7401 Rue Hochelaga, QC H1N 3M5, Montreal, Canada
4Département de Psychiatrie et d’Addictologie, Université de Montréal, Pavillon Roger-Gaudry, C.P. 6128, succursale Centre-ville, QC H3C 3J7, Montreal, Canada
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Clara Moreau
2Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, 4565 Queen Mary Rd, QC H3W 1W5, Montreal, Canada
5Sainte Justine Research Center, University of Montreal, 3175 Chemin de la Côte-Sainte-Catherine, QC H3T 1C5, Montreal, Canada
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Yassine Benhajali
2Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, 4565 Queen Mary Rd, QC H3W 1W5, Montreal, Canada
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Hien Duy Nguyen
6Department of Mathematics and Statistics, La Trobe University, Plenty Rd & Kingsbury Dr, VIC 3086, Bundoora, Australia
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Alan C. Evans
1Montreal Neurological Institute and Hospital, McGill University, 3801 Rue de l’Université, QC H3A 2B4, Montreal, Canada
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Pierre Bellec
2Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, 4565 Queen Mary Rd, QC H3W 1W5, Montreal, Canada
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  • For correspondence: sebastian.urchs@mail.mcgill.ca pierre.bellec@criugm.qc.ca
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Abstract

Our understanding of the changes in functional brain organization in autism is hampered by the extensive heterogeneity that characterizes this neurodevelopmental disorder. Data driven clustering offers a straightforward way to decompose this heterogeneity into subtypes of distinguishable connectivity types and promises an unbiased framework to investigate behavioural symptoms and causative genetic factors. Yet the robustness and generalizability of these imaging subtypes is unknown. Here, we show that unsupervised functional connectivity subtypes are moderately associated with the clinical diagnosis of autism, and that these associations generalize to independent replication data. We found that subtypes identified robust patterns of functional connectivity, but that a discrete assignment of individuals to these subtypes was not supported by the data. Our results support the use of data driven subtyping as a data dimensionality reduction technique, rather than to establish clinical categories.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted April 15, 2020.
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Subtypes of functional connectivity associate robustly with ASD diagnosis
Sebastian G. Urchs, Angela Tam, Pierre Orban, Clara Moreau, Yassine Benhajali, Hien Duy Nguyen, Alan C. Evans, Pierre Bellec
bioRxiv 2020.04.14.040576; doi: https://doi.org/10.1101/2020.04.14.040576
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Subtypes of functional connectivity associate robustly with ASD diagnosis
Sebastian G. Urchs, Angela Tam, Pierre Orban, Clara Moreau, Yassine Benhajali, Hien Duy Nguyen, Alan C. Evans, Pierre Bellec
bioRxiv 2020.04.14.040576; doi: https://doi.org/10.1101/2020.04.14.040576

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