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The FDA- approved gold drug Auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells

View ORCID ProfileHussin A. Rothan, Shannon Stone, Janhavi Natekar, Pratima Kumari, Komal Arora, View ORCID ProfileMukesh Kumar
doi: https://doi.org/10.1101/2020.04.14.041228
Hussin A. Rothan
1Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
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  • ORCID record for Hussin A. Rothan
  • For correspondence: hrothan@gsu.edu mkumar8@gsu.edu
Shannon Stone
1Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
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Janhavi Natekar
1Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
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Pratima Kumari
1Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
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Komal Arora
1Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
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Mukesh Kumar
1Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
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  • ORCID record for Mukesh Kumar
  • For correspondence: hrothan@gsu.edu mkumar8@gsu.edu
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Summary

SARS-COV-2 has recently emerged as a new public health threat. Herein, we report that the FDA-approved gold drug, auranofin, inhibits SARS-COV-2 replication in human cells at low micro molar concentration. Treatment of cells with auranofin resulted in a 95% reduction in the viral RNA at 48 hours after infection. Auranofin treatment dramatically reduced the expression of SARS-COV-2-induced cytokines in human cells. These data indicate that auranofin could be a useful drug to limit SARS-CoV-2 infection and associated lung injury due to its anti-viral, anti-inflammatory and anti-ROS properties. Auranofin has a well-known toxicity profile and is considered safe for human use.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 15, 2020.
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The FDA- approved gold drug Auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells
Hussin A. Rothan, Shannon Stone, Janhavi Natekar, Pratima Kumari, Komal Arora, Mukesh Kumar
bioRxiv 2020.04.14.041228; doi: https://doi.org/10.1101/2020.04.14.041228
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The FDA- approved gold drug Auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells
Hussin A. Rothan, Shannon Stone, Janhavi Natekar, Pratima Kumari, Komal Arora, Mukesh Kumar
bioRxiv 2020.04.14.041228; doi: https://doi.org/10.1101/2020.04.14.041228

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