Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry

So Young Kim; Weihua Jin; Amika Sood; David W. Montgomery; Oliver C. Grant; Mark M. Fuster; Li Fu; Jonathan S. Dordick; Robert J. Woods; Fuming Zhang; Robert J. Linhardt

doi:10.1101/2020.04.14.041459

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Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry

View ORCID ProfileSo Young Kim, Weihua Jin, Amika Sood, David W. Montgomery, Oliver C. Grant, Mark M. Fuster, Li Fu, Jonathan S. Dordick, Robert J. Woods, Fuming Zhang, Robert J. Linhardt

doi: https://doi.org/10.1101/2020.04.14.041459

So Young Kim

1Department of Medicine, Division of Pulmonary and Critical Care, University of California San Diego, La Jolla, California, United States of America

2VA San Diego Healthcare System, Medical and Research Sections, La Jolla, California, United States of America

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ORCID record for So Young Kim
For correspondence: y0k001@health.ucsd.edu zhangf2@rpi.edu linhar@rpi.edu

Weihua Jin

6Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York, United States of America

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Amika Sood

4Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, United States of America

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David W. Montgomery

5Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States of America

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Oliver C. Grant

5Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States of America

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Mark M. Fuster

1Department of Medicine, Division of Pulmonary and Critical Care, University of California San Diego, La Jolla, California, United States of America

2VA San Diego Healthcare System, Medical and Research Sections, La Jolla, California, United States of America

3Glycobiology Research and Training Center, University of California San Diego, La Jolla, California, United States of America

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Li Fu

6Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York, United States of America

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Jonathan S. Dordick

7Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, United States of America

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Robert J. Woods

5Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States of America

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Fuming Zhang

7Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, United States of America

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For correspondence: y0k001@health.ucsd.edu zhangf2@rpi.edu linhar@rpi.edu

Robert J. Linhardt

6Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York, United States of America

7Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, United States of America

8Department of Biological Science, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, United States of America

9Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, United States of America

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For correspondence: y0k001@health.ucsd.edu zhangf2@rpi.edu linhar@rpi.edu

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Posted April 15, 2020.

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Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry

So Young Kim, Weihua Jin, Amika Sood, David W. Montgomery, Oliver C. Grant, Mark M. Fuster, Li Fu, Jonathan S. Dordick, Robert J. Woods, Fuming Zhang, Robert J. Linhardt

bioRxiv 2020.04.14.041459; doi: https://doi.org/10.1101/2020.04.14.041459

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Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry

So Young Kim, Weihua Jin, Amika Sood, David W. Montgomery, Oliver C. Grant, Mark M. Fuster, Li Fu, Jonathan S. Dordick, Robert J. Woods, Fuming Zhang, Robert J. Linhardt

bioRxiv 2020.04.14.041459; doi: https://doi.org/10.1101/2020.04.14.041459

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