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Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics
View ORCID ProfileCarlos G. Acevedo-Rocha, View ORCID ProfileAitao Li, Lorenzo D’Amore, View ORCID ProfileSabrina Hoebenreich, View ORCID ProfileJoaquin Sanchis, View ORCID ProfilePaul Lubrano, View ORCID ProfileMatteo P. Ferla, View ORCID ProfileMarc Garcia-Borràs, View ORCID ProfileSílvia Osuna, View ORCID ProfileManfred T. Reetz
doi: https://doi.org/10.1101/2020.04.14.041590
Carlos G. Acevedo-Rocha
1Biosyntia ApS, 2100 Copenhagen, Denmark
Aitao Li
2State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, 430062, P. R. China
11Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin, 300308, P. R. China
Lorenzo D’Amore
3Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Carrer Maria Aurèlia Capmany 69, Girona 17003, Catalonia, Spain
Sabrina Hoebenreich
4Department of Chemistry, Philipps-University Marburg, 35032, Germany
Joaquin Sanchis
5Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville 3052, VIC, Australia
Paul Lubrano
6Max Planck Institute for Terrestrial Microbiology, Marburg, 35043, Germany
7LOEWE Zentrum für Synthetische Mikrobiologie SYNMIKRO, Philipps-Universität Marburg, 35032, Marburg, Germany
Matteo P. Ferla
8Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
Marc Garcia-Borràs
3Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Carrer Maria Aurèlia Capmany 69, Girona 17003, Catalonia, Spain
Sílvia Osuna
3Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Carrer Maria Aurèlia Capmany 69, Girona 17003, Catalonia, Spain
9ICREA, Pg. Lluís Companys 23, 08010 Barcelona, Spain
Manfred T. Reetz
4Department of Chemistry, Philipps-University Marburg, 35032, Germany
10Department of Biocatalysis, Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany
11Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin, 300308, P. R. China
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Posted April 16, 2020.
Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics
Carlos G. Acevedo-Rocha, Aitao Li, Lorenzo D’Amore, Sabrina Hoebenreich, Joaquin Sanchis, Paul Lubrano, Matteo P. Ferla, Marc Garcia-Borràs, Sílvia Osuna, Manfred T. Reetz
bioRxiv 2020.04.14.041590; doi: https://doi.org/10.1101/2020.04.14.041590
Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics
Carlos G. Acevedo-Rocha, Aitao Li, Lorenzo D’Amore, Sabrina Hoebenreich, Joaquin Sanchis, Paul Lubrano, Matteo P. Ferla, Marc Garcia-Borràs, Sílvia Osuna, Manfred T. Reetz
bioRxiv 2020.04.14.041590; doi: https://doi.org/10.1101/2020.04.14.041590
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