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A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors
Tayaza Fadason, Sreemol Gokuladhas, Evgeniia Golovina, Daniel Ho, Sophie Farrow, Denis Nyaga, Hong Pan, Neerja Karnani, Conroy Wong, Antony Cooper, View ORCID ProfileWilliam Schierding, View ORCID ProfileJustin M. O’Sullivan
doi: https://doi.org/10.1101/2020.04.14.042002
Tayaza Fadason
1The Liggins Institute, The University of Auckland, Auckland, New Zealand
2Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand
Sreemol Gokuladhas
1The Liggins Institute, The University of Auckland, Auckland, New Zealand
Evgeniia Golovina
1The Liggins Institute, The University of Auckland, Auckland, New Zealand
Daniel Ho
1The Liggins Institute, The University of Auckland, Auckland, New Zealand
Sophie Farrow
1The Liggins Institute, The University of Auckland, Auckland, New Zealand
Denis Nyaga
1The Liggins Institute, The University of Auckland, Auckland, New Zealand
Hong Pan
3Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
Neerja Karnani
3Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
4Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore
Conroy Wong
5Respiratory Medicine, Middlemore Hospital and University of Auckland, Auckland, New Zealand
Antony Cooper
6Australian Parkinsons Mission, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
7St Vincent’s Clinical School, UNSW Sydney, Sydney, New South Wales, Australia
William Schierding
1The Liggins Institute, The University of Auckland, Auckland, New Zealand
2Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand
Justin M. O’Sullivan
1The Liggins Institute, The University of Auckland, Auckland, New Zealand
2Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand
8Brain Research New Zealand, The University of Auckland, Auckland, New Zealand
Posted April 25, 2020.
A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors
Tayaza Fadason, Sreemol Gokuladhas, Evgeniia Golovina, Daniel Ho, Sophie Farrow, Denis Nyaga, Hong Pan, Neerja Karnani, Conroy Wong, Antony Cooper, William Schierding, Justin M. O’Sullivan
bioRxiv 2020.04.14.042002; doi: https://doi.org/10.1101/2020.04.14.042002
A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors
Tayaza Fadason, Sreemol Gokuladhas, Evgeniia Golovina, Daniel Ho, Sophie Farrow, Denis Nyaga, Hong Pan, Neerja Karnani, Conroy Wong, Antony Cooper, William Schierding, Justin M. O’Sullivan
bioRxiv 2020.04.14.042002; doi: https://doi.org/10.1101/2020.04.14.042002
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