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TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets
Dorothea Bestle, Miriam Ruth Heindl, Hannah Limburg, Thuy Van Lam van, Oliver Pilgram, Hong Moulton, David A. Stein, Kornelia Hardes, Markus Eickmann, Olga Dolnik, Cornelius Rohde, Stephan Becker, Hans-Dieter Klenk, Wolfgang Garten, Torsten Steinmetzer, Eva Böttcher-Friebertshäuser
doi: https://doi.org/10.1101/2020.04.15.042085
Dorothea Bestle
1Institute of Virology, Philipps-University, Marburg, Germany
Miriam Ruth Heindl
1Institute of Virology, Philipps-University, Marburg, Germany
Hannah Limburg
1Institute of Virology, Philipps-University, Marburg, Germany
Thuy Van Lam van
2Institute of Pharmaceutical Chemistry, Philipps-University, Marburg, Germany
Oliver Pilgram
2Institute of Pharmaceutical Chemistry, Philipps-University, Marburg, Germany
Hong Moulton
3Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, USA
David A. Stein
3Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, USA
Kornelia Hardes
2Institute of Pharmaceutical Chemistry, Philipps-University, Marburg, Germany
4Fraunhofer Institute for Molecular Biology and Applied Ecology, Gießen, Germany
Markus Eickmann
1Institute of Virology, Philipps-University, Marburg, Germany
5German Center for Infection Research (DZIF), Marburg-Gießen-Langen Site, Emerging Infections Unit, Philipps-University, Marburg, Germany
Olga Dolnik
1Institute of Virology, Philipps-University, Marburg, Germany
5German Center for Infection Research (DZIF), Marburg-Gießen-Langen Site, Emerging Infections Unit, Philipps-University, Marburg, Germany
Cornelius Rohde
1Institute of Virology, Philipps-University, Marburg, Germany
5German Center for Infection Research (DZIF), Marburg-Gießen-Langen Site, Emerging Infections Unit, Philipps-University, Marburg, Germany
Stephan Becker
1Institute of Virology, Philipps-University, Marburg, Germany
5German Center for Infection Research (DZIF), Marburg-Gießen-Langen Site, Emerging Infections Unit, Philipps-University, Marburg, Germany
Hans-Dieter Klenk
1Institute of Virology, Philipps-University, Marburg, Germany
Wolfgang Garten
1Institute of Virology, Philipps-University, Marburg, Germany
Torsten Steinmetzer
2Institute of Pharmaceutical Chemistry, Philipps-University, Marburg, Germany
Eva Böttcher-Friebertshäuser
1Institute of Virology, Philipps-University, Marburg, Germany
Article usage
Posted April 15, 2020.
TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets
Dorothea Bestle, Miriam Ruth Heindl, Hannah Limburg, Thuy Van Lam van, Oliver Pilgram, Hong Moulton, David A. Stein, Kornelia Hardes, Markus Eickmann, Olga Dolnik, Cornelius Rohde, Stephan Becker, Hans-Dieter Klenk, Wolfgang Garten, Torsten Steinmetzer, Eva Böttcher-Friebertshäuser
bioRxiv 2020.04.15.042085; doi: https://doi.org/10.1101/2020.04.15.042085
TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets
Dorothea Bestle, Miriam Ruth Heindl, Hannah Limburg, Thuy Van Lam van, Oliver Pilgram, Hong Moulton, David A. Stein, Kornelia Hardes, Markus Eickmann, Olga Dolnik, Cornelius Rohde, Stephan Becker, Hans-Dieter Klenk, Wolfgang Garten, Torsten Steinmetzer, Eva Böttcher-Friebertshäuser
bioRxiv 2020.04.15.042085; doi: https://doi.org/10.1101/2020.04.15.042085
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