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Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics

Nils C. Gassen, Jan Papies, Thomas Bajaj, Frederik Dethloff, Jackson Emanuel, Katja Weckmann, Daniel E. Heinz, Nicolas Heinemann, Martina Lennarz, Anja Richter, Daniela Niemeyer, Victor M. Corman, Patrick Giavalisco, Christian Drosten, Marcel A. Müller
doi: https://doi.org/10.1101/2020.04.15.997254
Nils C. Gassen
1Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany
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  • For correspondence: nils.gassen@ukbonn.de marcel.mueller@charite.de
Jan Papies
2Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
3German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany
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Thomas Bajaj
1Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany
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Frederik Dethloff
4Max Planck Institute for Aging, 50931 Cologne, Germany
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Jackson Emanuel
2Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
3German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany
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Katja Weckmann
1Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany
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Daniel E. Heinz
1Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany
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Nicolas Heinemann
2Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
3German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany
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Martina Lennarz
1Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany
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Anja Richter
2Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
3German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany
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Daniela Niemeyer
2Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
3German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany
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Victor M. Corman
2Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
3German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany
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Patrick Giavalisco
4Max Planck Institute for Aging, 50931 Cologne, Germany
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Christian Drosten
2Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
3German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany
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Marcel A. Müller
2Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
3German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany
5Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, 119991 Moscow, Russia
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  • For correspondence: nils.gassen@ukbonn.de marcel.mueller@charite.de
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Article Information

doi 
https://doi.org/10.1101/2020.04.15.997254
History 
  • April 15, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Nils C. Gassen1,$,
  2. Jan Papies2,3,
  3. Thomas Bajaj1,
  4. Frederik Dethloff4,
  5. Jackson Emanuel2,3,
  6. Katja Weckmann1,
  7. Daniel E. Heinz1,
  8. Nicolas Heinemann2,3,
  9. Martina Lennarz1,
  10. Anja Richter2,3,
  11. Daniela Niemeyer2,3,
  12. Victor M. Corman2,3,
  13. Patrick Giavalisco4,
  14. Christian Drosten2,3 and
  15. Marcel A. Müller2,3,5,$
  1. 1Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany
  2. 2Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
  3. 3German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany
  4. 4Max Planck Institute for Aging, 50931 Cologne, Germany
  5. 5Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, 119991 Moscow, Russia
  1. ↵$Contact: Correspondence should be addressed to Nils C. Gassen (nils.gassen{at}ukbonn.de) or Marcel A. Müller (marcel.mueller{at}charite.de)
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Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
Nils C. Gassen, Jan Papies, Thomas Bajaj, Frederik Dethloff, Jackson Emanuel, Katja Weckmann, Daniel E. Heinz, Nicolas Heinemann, Martina Lennarz, Anja Richter, Daniela Niemeyer, Victor M. Corman, Patrick Giavalisco, Christian Drosten, Marcel A. Müller
bioRxiv 2020.04.15.997254; doi: https://doi.org/10.1101/2020.04.15.997254
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Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
Nils C. Gassen, Jan Papies, Thomas Bajaj, Frederik Dethloff, Jackson Emanuel, Katja Weckmann, Daniel E. Heinz, Nicolas Heinemann, Martina Lennarz, Anja Richter, Daniela Niemeyer, Victor M. Corman, Patrick Giavalisco, Christian Drosten, Marcel A. Müller
bioRxiv 2020.04.15.997254; doi: https://doi.org/10.1101/2020.04.15.997254

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