New Results
G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules
View ORCID ProfileMirja T. Prentzell, View ORCID ProfileUlrike Rehbein, View ORCID ProfileMarti Cadena Sandoval, Ann-Sofie De Meulemeester, View ORCID ProfileRalf Baumeister, View ORCID ProfileLaura Brohée, View ORCID ProfileBianca Berdel, View ORCID ProfileMathias Bockwoldt, View ORCID ProfileBernadette Carroll, Andreas von Deimling, View ORCID ProfileConstantinos Demetriades, Gianluca Figlia, View ORCID ProfileAlexander M. Heberle, View ORCID ProfileInes Heiland, Birgit Holzwarth, View ORCID ProfileLukas A. Huber, View ORCID ProfileJacek Jaworski, Katharina Kern, View ORCID ProfileAndrii Kopach, View ORCID ProfileViktor I. Korolchuk, Ineke van ’t Land-Kuper, View ORCID ProfileMatylda Macias, Mark Nellist, Stefan Pusch, Michele Reil, Anja Reintjes, Friederike Reuter, Chloë Scheldeman, Eduard Stefan, Aurelio Teleman, Omar Torres-Quesada, Saskia Trump, View ORCID ProfilePeter de Witte, View ORCID ProfileTeodor Yordanov, View ORCID ProfileChristiane A. Opitz, View ORCID ProfileKathrin Thedieck
doi: https://doi.org/10.1101/2020.04.16.044081
Mirja T. Prentzell
1Brain Cancer Metabolism Group, German Consortium of Translational Cancer Research (DKTK) & German Cancer Research Center (DKFZ), Heidelberg, Germany
2Department of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, The Netherlands
3Department of Bioinformatics and Molecular Genetics (Faculty of Biology), University of Freiburg, Germany
4Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Germany
Ulrike Rehbein
2Department of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, The Netherlands
5Department for Neuroscience, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Germany
Marti Cadena Sandoval
2Department of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, The Netherlands
6Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Austria
Ann-Sofie De Meulemeester
7Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Belgium
Ralf Baumeister
3Department of Bioinformatics and Molecular Genetics (Faculty of Biology), University of Freiburg, Germany
4Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Germany
8Signalling Research Centres BIOSS and CIBSS & ZBMZ Center for Biochemistry and Molecular Cell Research (Faculty of Medicine), University of Freiburg, Germany
Laura Brohée
9Max Planck Institute for Biology of Ageing (MPI-AGE), Cologne, Germany
Bianca Berdel
1Brain Cancer Metabolism Group, German Consortium of Translational Cancer Research (DKTK) & German Cancer Research Center (DKFZ), Heidelberg, Germany
Mathias Bockwoldt
10Department of Arctic and Marine Biology, UiT The Arctic University of Norway, 9037 Tromsø, Norway
Bernadette Carroll
11School of Biochemistry, Biomedical Sciences Building, University Walk, Bristol, UK
Andreas von Deimling
12German Consortium of Translational Cancer Research (DKTK), Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ) & Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Germany
Constantinos Demetriades
9Max Planck Institute for Biology of Ageing (MPI-AGE), Cologne, Germany
13CECAD Cluster of Excellence, University of Cologne, Germany
Gianluca Figlia
14German Cancer Research Center (DKFZ), Heidelberg, Germany
15Heidelberg University, Heidelberg, Germany
Alexander M. Heberle
2Department of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, The Netherlands
6Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Austria
Ines Heiland
10Department of Arctic and Marine Biology, UiT The Arctic University of Norway, 9037 Tromsø, Norway
Birgit Holzwarth
3Department of Bioinformatics and Molecular Genetics (Faculty of Biology), University of Freiburg, Germany
Lukas A. Huber
16Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
17Austrian Drug Screening Institute, ADSI, Innsbruck, Austria
Jacek Jaworski
18Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology in Warsaw, Poland
Katharina Kern
1Brain Cancer Metabolism Group, German Consortium of Translational Cancer Research (DKTK) & German Cancer Research Center (DKFZ), Heidelberg, Germany
Andrii Kopach
18Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology in Warsaw, Poland
Viktor I. Korolchuk
19Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Ineke van ’t Land-Kuper
2Department of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, The Netherlands
5Department for Neuroscience, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Germany
Matylda Macias
18Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology in Warsaw, Poland
Mark Nellist
20Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
Stefan Pusch
12German Consortium of Translational Cancer Research (DKTK), Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ) & Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Germany
Michele Reil
1Brain Cancer Metabolism Group, German Consortium of Translational Cancer Research (DKTK) & German Cancer Research Center (DKFZ), Heidelberg, Germany
Anja Reintjes
6Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Austria
Friederike Reuter
1Brain Cancer Metabolism Group, German Consortium of Translational Cancer Research (DKTK) & German Cancer Research Center (DKFZ), Heidelberg, Germany
Chloë Scheldeman
7Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Belgium
21Neurogenetics research group, VUB, Brussels, Belgium
Eduard Stefan
6Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Austria
Aurelio Teleman
14German Cancer Research Center (DKFZ), Heidelberg, Germany
15Heidelberg University, Heidelberg, Germany
Omar Torres-Quesada
6Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Austria
Saskia Trump
22Molecular Epidemiology Unit, Charité-Universitätsmedizin Berlin & Berlin Institute of Health, Berlin, Germany
Peter de Witte
7Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Belgium
Teodor Yordanov
16Institute of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
23Division of Cell and Developmental Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
Christiane A. Opitz
1Brain Cancer Metabolism Group, German Consortium of Translational Cancer Research (DKTK) & German Cancer Research Center (DKFZ), Heidelberg, Germany
24Department of Neurology, University Hospital Heidelberg and National Center for Tumor Diseases, Heidelberg, Germany
Kathrin Thedieck
2Department of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, The Netherlands
5Department for Neuroscience, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Germany
6Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Austria
Posted April 22, 2020.
G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules
Mirja T. Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Katharina Kern, Andrii Kopach, Viktor I. Korolchuk, Ineke van ’t Land-Kuper, Matylda Macias, Mark Nellist, Stefan Pusch, Michele Reil, Anja Reintjes, Friederike Reuter, Chloë Scheldeman, Eduard Stefan, Aurelio Teleman, Omar Torres-Quesada, Saskia Trump, Peter de Witte, Teodor Yordanov, Christiane A. Opitz, Kathrin Thedieck
bioRxiv 2020.04.16.044081; doi: https://doi.org/10.1101/2020.04.16.044081
G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules
Mirja T. Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Katharina Kern, Andrii Kopach, Viktor I. Korolchuk, Ineke van ’t Land-Kuper, Matylda Macias, Mark Nellist, Stefan Pusch, Michele Reil, Anja Reintjes, Friederike Reuter, Chloë Scheldeman, Eduard Stefan, Aurelio Teleman, Omar Torres-Quesada, Saskia Trump, Peter de Witte, Teodor Yordanov, Christiane A. Opitz, Kathrin Thedieck
bioRxiv 2020.04.16.044081; doi: https://doi.org/10.1101/2020.04.16.044081
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