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Self-organized patterning of cell morphology via mechanosensitive feedback

View ORCID ProfileNatalie A. Dye, View ORCID ProfileMarko Popovic, View ORCID ProfileK. Venkatesan Iyer, View ORCID ProfileSuzanne Eaton, View ORCID ProfileFrank Julicher
doi: https://doi.org/10.1101/2020.04.16.044883
Natalie A. Dye
1Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
2Cluster of Excellence Physics of Life, TU Dresden, 01062 Dresden, Germany
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  • For correspondence: dye@mpi-cbg.de julicher@mpi-pks.de
Marko Popovic
3Institute of Physics, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
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K. Venkatesan Iyer
1Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
2Cluster of Excellence Physics of Life, TU Dresden, 01062 Dresden, Germany
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Suzanne Eaton
1Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
2Cluster of Excellence Physics of Life, TU Dresden, 01062 Dresden, Germany
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Frank Julicher
2Cluster of Excellence Physics of Life, TU Dresden, 01062 Dresden, Germany
4Max Planck Institute for Physics of Complex Systems, Nöthnitzer Strasse 38, 01187 Dresden, Germany
5Center for Systems Biology Dresden, 01307 Dresden, Germany
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  • For correspondence: dye@mpi-cbg.de julicher@mpi-pks.de
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ABSTRACT

Tissue organization is often characterized by specific patterns of cell morphology. How such patterns emerge in developing tissues is a fundamental open question. Here, we investigate the emergence of tissue-scale patterns of cell shape and mechanical tissue stress in the Drosophila wing imaginal disc during larval development. Using quantitative analysis of the cellular dynamics, we reveal a pattern of radially oriented cell rearrangements that is coupled to the buildup of tangential cell elongation. Developing a laser ablation method, we map tissue stresses and extract key parameters of tissue mechanics. We present a continuum theory showing that this pattern of cell morphology and tissue stress can arise via self-organization of a mechanical feedback that couples cell polarity to active cell rearrangements. The predictions of this model are supported by knockdown of MyoVI, a component of mechanosensitive feedback. Our work reveals a mechanism for the emergence of cellular patterns in morphogenesis.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵§ Lead author: dye{at}mpi-cbg.de

  • ↵† Author deceased

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted April 18, 2020.
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Self-organized patterning of cell morphology via mechanosensitive feedback
Natalie A. Dye, Marko Popovic, K. Venkatesan Iyer, Suzanne Eaton, Frank Julicher
bioRxiv 2020.04.16.044883; doi: https://doi.org/10.1101/2020.04.16.044883
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Self-organized patterning of cell morphology via mechanosensitive feedback
Natalie A. Dye, Marko Popovic, K. Venkatesan Iyer, Suzanne Eaton, Frank Julicher
bioRxiv 2020.04.16.044883; doi: https://doi.org/10.1101/2020.04.16.044883

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