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Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts

Jeffrey J. Quinn, Matthew G. Jones, Ross A. Okimoto, Shigeki Nanjo, Michelle M. Chan, Nir Yosef, Trever G. Bivona, Jonathan S. Weissman
doi: https://doi.org/10.1101/2020.04.16.045245
Jeffrey J. Quinn
1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA
2Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA
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Matthew G. Jones
1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA
2Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA
3Biological and Medical Informatics Graduate Program, University of California, San Francisco, San Francisco, CA, USA
4Integrative Program in Quantitative Biology, University of California, San Francisco, San Francisco, CA, USA
10Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA
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Ross A. Okimoto
5UCSF Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
6Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA
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Shigeki Nanjo
5UCSF Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
6Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA
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Michelle M. Chan
1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA
2Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA
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Nir Yosef
7Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA, USA
8Chan Zuckerberg Biohub Investigator, San Francisco, CA, USA
9Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Cambridge, MA, USA
10Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA
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  • For correspondence: weissman@wi.mit.edu Trever.Bivona@ucsf.edu niryosef@berkeley.edu
Trever G. Bivona
1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA
5UCSF Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
6Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA
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  • For correspondence: weissman@wi.mit.edu Trever.Bivona@ucsf.edu niryosef@berkeley.edu
Jonathan S. Weissman
1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA
2Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA
11Whitehead Institute, Cambridge, MA, USA
12Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
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  • For correspondence: weissman@wi.mit.edu Trever.Bivona@ucsf.edu niryosef@berkeley.edu
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Posted September 21, 2020.
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Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts
Jeffrey J. Quinn, Matthew G. Jones, Ross A. Okimoto, Shigeki Nanjo, Michelle M. Chan, Nir Yosef, Trever G. Bivona, Jonathan S. Weissman
bioRxiv 2020.04.16.045245; doi: https://doi.org/10.1101/2020.04.16.045245
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Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts
Jeffrey J. Quinn, Matthew G. Jones, Ross A. Okimoto, Shigeki Nanjo, Michelle M. Chan, Nir Yosef, Trever G. Bivona, Jonathan S. Weissman
bioRxiv 2020.04.16.045245; doi: https://doi.org/10.1101/2020.04.16.045245

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