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Archaeogenetic analysis of Neolithic sheep from Anatolia suggests a complex demographic history since domestication

Erinç Yurtman, Onur Özer, Eren Yüncü, Nihan Dilşad Dağtaş, Dilek Koptekin, Yasin Gökhan Çakan, Mustafa Özkan, Ali Akbaba, Damla Kaptan, Gözde Atağ, Kıvılcım Başak Vural, Can Yümni Gündem, Louise Martin, Gülşah Merve Kılınç, Ayshin Ghalichi, Sinan Can Açan, Reyhan Yaka, Ekin Sağlıcan, Vendela Kempe Lagerholm, Maja Krzewinska, Evangelia Pişkin, Müge Şevketoğlu, C. Can Bilgin, Çiğdem Atakuman, Yılmaz Selim Erdal, Elif Sürer, Johannes Lenstra, Sevgi Yorulmaz, Foad Abazari, Javad Hoseinzadeh, Douglas Baird, Erhan Bıçakçı, Özlem Çevik, Fokke Gerritsen, Rana Özbal, Anders Götherström, Mehmet Somel, İnci Togan, Füsun Özer
doi: https://doi.org/10.1101/2020.04.17.033415
Erinç Yurtman
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
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Onur Özer
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
2Emmy Noether Group Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, 24306 Plön, Germany
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Eren Yüncü
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
3Department of Biology and Ecology, University of Ostrava, Ostrava, Czechia
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Nihan Dilşad Dağtaş
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
4Department of Anthropology, University of Oklahoma, Norman, OK 73019
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Dilek Koptekin
5Department of Health Informatics, Middle East Technical University, 06800 Ankara, Turkey
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Yasin Gökhan Çakan
6Department of Prehistory, Istanbul University, Laleli, 34134 Istanbul, Turkey
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Mustafa Özkan
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
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Ali Akbaba
7Department of Anthropology, Ankara University, 06100 Ankara, Turkey
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Damla Kaptan
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
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Gözde Atağ
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
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Kıvılcım Başak Vural
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
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Can Yümni Gündem
8Department of Archaeology, Batman University, 72100 Batman, Turkey
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Louise Martin
9Institute of Archaeology, University College London, UK
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Gülşah Merve Kılınç
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
10Department of Bioinformatics, Graduate School of Health Sciences, Hacettepe University, 06100, Ankara, Turkey
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Ayshin Ghalichi
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
11Department of Archaeogenetics, Max-Planck Institute for the Science of Human History, Kahlaische Strasse 10, D-07745, Jena, Germany
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Sinan Can Açan
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
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Reyhan Yaka
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Ekin Sağlıcan
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
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Vendela Kempe Lagerholm
12Archaeological Research Laboratory, Department of Archaeology and Classical Studies, University of Stockholm, Lilla Frescativ€agen 7, 106 91 Stockholm, Sweden
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Maja Krzewinska
12Archaeological Research Laboratory, Department of Archaeology and Classical Studies, University of Stockholm, Lilla Frescativ€agen 7, 106 91 Stockholm, Sweden
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Evangelia Pişkin
13Department of Settlement Archaeology, Middle East Technical University, 06800 Ankara, Turkey
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Müge Şevketoğlu
14Centre for Archaeology, Cultural Heritage and Conservation, Cyprus International University, Haspolat, Cyprus
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C. Can Bilgin
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
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Çiğdem Atakuman
13Department of Settlement Archaeology, Middle East Technical University, 06800 Ankara, Turkey
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Yılmaz Selim Erdal
15Department of Anthropology, Hacettepe University, 06800 Ankara, Turkey
16Hacettepe University Molecular Anthropology Group (Human_G) 06800, Ankara, Turkey
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Elif Sürer
17Department of Modeling and Simulation, Graduate School of Informatics, Middle East Technical University, 06800 Ankara, Turkey
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Johannes Lenstra
18Faculty of Veterinary Medicine, Utrecht Univ., Utrecht, Netherlands
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Sevgi Yorulmaz
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
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Foad Abazari
19Department of Genetics, Azad University, Varamin Branch, Tehran
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Javad Hoseinzadeh
20Department of Archaeology, University of Kashan, Kashan, Iran
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Douglas Baird
21Department of Archaeology, Classics, and Egyptology, University of Liverpool, Liverpool L69 7WZ, UK
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Erhan Bıçakçı
6Department of Prehistory, Istanbul University, Laleli, 34134 Istanbul, Turkey
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Özlem Çevik
22Department of Archaeology, Trakya University, 22030 Edirne, Turkey
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Fokke Gerritsen
23Netherlands Institute in Turkey, Istanbul, TR
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Rana Özbal
24Department of Archaeology and History of Art, Koç University, 34450 Istanbul, Turkey
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Anders Götherström
12Archaeological Research Laboratory, Department of Archaeology and Classical Studies, University of Stockholm, Lilla Frescativ€agen 7, 106 91 Stockholm, Sweden
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Mehmet Somel
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
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  • For correspondence: fusunozer@hacettepe.edu.tr msomel@metu.edu.tr
İnci Togan
1Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey
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Füsun Özer
15Department of Anthropology, Hacettepe University, 06800 Ankara, Turkey
16Hacettepe University Molecular Anthropology Group (Human_G) 06800, Ankara, Turkey
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  • For correspondence: fusunozer@hacettepe.edu.tr msomel@metu.edu.tr
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Abstract

Sheep was among the first domesticated animals, but its demographic history is little understood. Here we present combined analyses of mitochondrial and nuclear polymorphism data from ancient central and west Anatolian sheep dating to the Late Glacial and early Holocene. We observe loss of mitochondrial haplotype diversity around 7500 BCE during the early Neolithic, consistent with a domestication-related bottleneck. Post-7000 BCE, mitochondrial haplogroup diversity increases, compatible with admixture from other domestication centres and/or from wild populations. Analysing archaeogenomic data, we further find that Anatolian Neolithic sheep (ANS) are genetically closest to present-day European breeds, and especially those from central and north Europe. Our results indicate that Asian contribution to south European breeds in the post-Neolithic era, possibly during the Bronze Age, may explain this pattern.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Archaeogenetic analysis of Neolithic sheep from Anatolia suggests a complex demographic history since domestication
Erinç Yurtman, Onur Özer, Eren Yüncü, Nihan Dilşad Dağtaş, Dilek Koptekin, Yasin Gökhan Çakan, Mustafa Özkan, Ali Akbaba, Damla Kaptan, Gözde Atağ, Kıvılcım Başak Vural, Can Yümni Gündem, Louise Martin, Gülşah Merve Kılınç, Ayshin Ghalichi, Sinan Can Açan, Reyhan Yaka, Ekin Sağlıcan, Vendela Kempe Lagerholm, Maja Krzewinska, Evangelia Pişkin, Müge Şevketoğlu, C. Can Bilgin, Çiğdem Atakuman, Yılmaz Selim Erdal, Elif Sürer, Johannes Lenstra, Sevgi Yorulmaz, Foad Abazari, Javad Hoseinzadeh, Douglas Baird, Erhan Bıçakçı, Özlem Çevik, Fokke Gerritsen, Rana Özbal, Anders Götherström, Mehmet Somel, İnci Togan, Füsun Özer
bioRxiv 2020.04.17.033415; doi: https://doi.org/10.1101/2020.04.17.033415
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Archaeogenetic analysis of Neolithic sheep from Anatolia suggests a complex demographic history since domestication
Erinç Yurtman, Onur Özer, Eren Yüncü, Nihan Dilşad Dağtaş, Dilek Koptekin, Yasin Gökhan Çakan, Mustafa Özkan, Ali Akbaba, Damla Kaptan, Gözde Atağ, Kıvılcım Başak Vural, Can Yümni Gündem, Louise Martin, Gülşah Merve Kılınç, Ayshin Ghalichi, Sinan Can Açan, Reyhan Yaka, Ekin Sağlıcan, Vendela Kempe Lagerholm, Maja Krzewinska, Evangelia Pişkin, Müge Şevketoğlu, C. Can Bilgin, Çiğdem Atakuman, Yılmaz Selim Erdal, Elif Sürer, Johannes Lenstra, Sevgi Yorulmaz, Foad Abazari, Javad Hoseinzadeh, Douglas Baird, Erhan Bıçakçı, Özlem Çevik, Fokke Gerritsen, Rana Özbal, Anders Götherström, Mehmet Somel, İnci Togan, Füsun Özer
bioRxiv 2020.04.17.033415; doi: https://doi.org/10.1101/2020.04.17.033415

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