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Visible light optical coherence tomography angiography (vis-OCTA) and local microvascular retinal oximetry in human retina

View ORCID ProfileWeiye Song, View ORCID ProfileWenjun Shao, Wei Yi, Rongrong Liu, Manishi Desai, Steven Ness, View ORCID ProfileJi Yi
doi: https://doi.org/10.1101/2020.04.17.047514
Weiye Song
1Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, 02118, USA
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Wenjun Shao
1Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, 02118, USA
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Wei Yi
1Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, 02118, USA
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Rongrong Liu
4Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA
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Manishi Desai
5Department of Ophthalmology, Boston University School of Medicine, Boston Medical Center, Boston, 02118, USA
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Steven Ness
5Department of Ophthalmology, Boston University School of Medicine, Boston Medical Center, Boston, 02118, USA
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Ji Yi
1Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, 02118, USA
2Department of Biomedical Engineering, Boston University, Boston, 02118, USA
3Department of Electronic and Computer Engineering, Boston University, Boston, 02118, USA
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  • For correspondence: jiyi@bu.edu
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Abstract

We report herein the first visible light optical coherence tomography angiography (vis-OCTA) for human retinal imaging. Compared to the existing vis-OCT systems, we devised a spectrometer with a narrower bandwidth to increase the spectral power density for OCTA imaging, while retaining the major spectral contrast in the blood. We achieved a 100 kHz A-line rate, the fastest acquisition speed reported so far for human retinal vis-OCT. We rigorously optimized the imaging protocol such that a single acquisition takes <6 seconds with a field of view (FOV) of 3×7.8 mm2. The angiography enables accurate localization of microvasculature down to the capillary level and thus enables oximetry at vessels < 100 μm in diameter. We demonstrated microvascular hemoglobin oxygen saturation (sO2) at the feeding and draining vessels at the perifoveal region. The longitudinal repeatability was assessed by <5% coefficient of variation (CV). The unique capabilities of our vis-OCTA system may allow studies on the role of microvascular oxygen in various retinal pathologies.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted April 18, 2020.
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Visible light optical coherence tomography angiography (vis-OCTA) and local microvascular retinal oximetry in human retina
Weiye Song, Wenjun Shao, Wei Yi, Rongrong Liu, Manishi Desai, Steven Ness, Ji Yi
bioRxiv 2020.04.17.047514; doi: https://doi.org/10.1101/2020.04.17.047514
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Visible light optical coherence tomography angiography (vis-OCTA) and local microvascular retinal oximetry in human retina
Weiye Song, Wenjun Shao, Wei Yi, Rongrong Liu, Manishi Desai, Steven Ness, Ji Yi
bioRxiv 2020.04.17.047514; doi: https://doi.org/10.1101/2020.04.17.047514

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