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Consumption of artificially sweetened beverages during pregnancy impacts infant gut microbiota and body mass index

View ORCID ProfileIsabelle Laforest-Lapointe, Allan B. Becker, Piushkumar J. Mandhane, Stuart E. Turvey, Theo J. Moraes, Malcolm R. Sears, Padmaja Subbarao, Laura K. Sycuro, View ORCID ProfileMeghan B. Azad, Marie-Claire Arrieta
doi: https://doi.org/10.1101/2020.04.20.050195
Isabelle Laforest-Lapointe
1University of Calgary, Physiology and Pharmacology, Calgary, Alberta, Canada
2University of Calgary, Pediatrics, Calgary, Alberta, Canada
3Université de Sherbrooke, Biologie, Sherbrooke, Québec, Canada
4Alberta Children’s Hospital Research Institute (ACHRI), Calgary, Alberta, Canada
5University of Calgary, Snyder Institute for Chronic Diseases, Calgary, Alberta, Canada
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  • ORCID record for Isabelle Laforest-Lapointe
  • For correspondence: Isabelle.laforest-lapointe@usherbrooke.ca Meghan.Azad@umanitoba.ca marie.arrieta@ucalgary.ca
Allan B. Becker
6University of Manitoba, Pediatrics and Child Health, Winnipeg, Manitoba, Canada
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Piushkumar J. Mandhane
7University of Alberta, Pediatrics, Edmonton, Alberta, Canada
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Stuart E. Turvey
8The University of British Columbia, British Columbia Children’s Hospital, Vancouver, British Columbia, Canada
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Theo J. Moraes
9University of Toronto, Pediatrics, Toronto, Ontario, Canada
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Malcolm R. Sears
10McMaster University, Medicine, Hamilton, Ontario, Canada
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Padmaja Subbarao
9University of Toronto, Pediatrics, Toronto, Ontario, Canada
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Laura K. Sycuro
5University of Calgary, Snyder Institute for Chronic Diseases, Calgary, Alberta, Canada
11University of Calgary, Microbiology, Immunology, and Infectious Diseases, Calgary, Alberta, Canada
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Meghan B. Azad
6University of Manitoba, Pediatrics and Child Health, Winnipeg, Manitoba, Canada
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  • ORCID record for Meghan B. Azad
  • For correspondence: Isabelle.laforest-lapointe@usherbrooke.ca Meghan.Azad@umanitoba.ca marie.arrieta@ucalgary.ca
Marie-Claire Arrieta
1University of Calgary, Physiology and Pharmacology, Calgary, Alberta, Canada
2University of Calgary, Pediatrics, Calgary, Alberta, Canada
4Alberta Children’s Hospital Research Institute (ACHRI), Calgary, Alberta, Canada
5University of Calgary, Snyder Institute for Chronic Diseases, Calgary, Alberta, Canada
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  • For correspondence: Isabelle.laforest-lapointe@usherbrooke.ca Meghan.Azad@umanitoba.ca marie.arrieta@ucalgary.ca
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ABSTRACT

Artificial sweetener consumption by pregnant women has been associated with an increased risk of infant obesity, but the underlying mechanisms are unknown. We aimed to determine if maternal consumption of artificially sweetened beverages (ASB) during pregnancy is associated with modifications of infant gut bacterial community composition during the first year of life, and whether these alterations are linked with infant body mass index (BMI) at one year of age. This research included 100 infants from the prospective Canadian CHILD Cohort Study, selected based on maternal ASB consumption during pregnancy (50 non-consumers and 50 daily consumers). We identified four microbiome clusters, of which two recapitulated the maturation trajectory of the infant gut bacterial communities from immature to mature and two deviated from this trajectory. Maternal ASB consumption was associated with the depletion of several Bacteroides sp. and higher infant BMI. As we face an unprecedented rise in childhood obesity, future studies should evaluate the causal role of gut microbiota in the association between maternal ASB consumption, infant development and metabolism, and body composition.

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Posted April 21, 2020.
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Consumption of artificially sweetened beverages during pregnancy impacts infant gut microbiota and body mass index
Isabelle Laforest-Lapointe, Allan B. Becker, Piushkumar J. Mandhane, Stuart E. Turvey, Theo J. Moraes, Malcolm R. Sears, Padmaja Subbarao, Laura K. Sycuro, Meghan B. Azad, Marie-Claire Arrieta
bioRxiv 2020.04.20.050195; doi: https://doi.org/10.1101/2020.04.20.050195
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Consumption of artificially sweetened beverages during pregnancy impacts infant gut microbiota and body mass index
Isabelle Laforest-Lapointe, Allan B. Becker, Piushkumar J. Mandhane, Stuart E. Turvey, Theo J. Moraes, Malcolm R. Sears, Padmaja Subbarao, Laura K. Sycuro, Meghan B. Azad, Marie-Claire Arrieta
bioRxiv 2020.04.20.050195; doi: https://doi.org/10.1101/2020.04.20.050195

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