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Excitatory and inhibitory L2/3 neurons in mouse primary visual cortex are balanced in their input connectivity

Alexander P.Y. Brown, Lee Cossell, Troy W. Margrie
doi: https://doi.org/10.1101/2020.04.21.053504
Alexander P.Y. Brown
1Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, 25 Howland Street, London W1T 4JG, United Kingdom
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Lee Cossell
1Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, 25 Howland Street, London W1T 4JG, United Kingdom
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Troy W. Margrie
1Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, 25 Howland Street, London W1T 4JG, United Kingdom
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  • For correspondence: t.margrie@ucl.ac.uk
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Abstract

Quantitatively characterising brain-wide connectivity of neural circuits is of vital importance in understanding the function of the mammalian cortex. Here we have designed an analytical approach to examine data from hierarchical segmentation ontologies, and applied it in the comparison of long-range presynaptic connectivity onto excitatory and inhibitory neurons in layer 2/3 (L2/3) of mouse primary visual cortex (V1). We find that long-range connections onto these two general cell classes in L2/3 originate from highly similar brain regions, and in similar proportions, when compared to input to layer 6. These anatomical data suggest that distal information received by excitatory and inhibitory networks is highly homogenous in L2/3.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 23, 2020.
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Excitatory and inhibitory L2/3 neurons in mouse primary visual cortex are balanced in their input connectivity
Alexander P.Y. Brown, Lee Cossell, Troy W. Margrie
bioRxiv 2020.04.21.053504; doi: https://doi.org/10.1101/2020.04.21.053504
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Excitatory and inhibitory L2/3 neurons in mouse primary visual cortex are balanced in their input connectivity
Alexander P.Y. Brown, Lee Cossell, Troy W. Margrie
bioRxiv 2020.04.21.053504; doi: https://doi.org/10.1101/2020.04.21.053504

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