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History
- May 9, 2020.
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- Version 1 (April 23, 2020 - 00:31).
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
Author Information
- Matthias Fellner1,*,
- Christian S. Lentz2,3,
- Sam A. Jamieson1,
- Jodi L. Brewster1,
- Linhai Chen2,4,
- Matthew Bogyo2 and
- Peter D. Mace1
- 1Biochemistry, University of Otago, New Zealand
- 2Department of Pathology, Stanford University, USA
- 3Centre for New Antibacterial Strategies (CANS) and Research Group for Host-Microbe Interactions, Department of Medical Biology, UiT – The Arctic University of Norway, Norway
- 4National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China
- ↵*Corresponding Author and Lead Contact: matthias.fellner{at}otago.ac.nz
Author Contributions: M.F. and P.M. conceptualization; M.F., C.L. and S.J. purification; C.L. activity and inhibition assays; M.F. and S.J. crystallization; M.F. and J.B. data collection and processing; M.F. data deposition, curation and analysis; M.F. model prediction; M.F. docking studies; L.C. chemistry analysis; M.F., C.L., M.B. and P.M. writing, review and editing; M.F., C.L., L.C. and P.M. visualization; M.F., C.L., M.B. and P.M. funding acquisition; M.F., C.L., M.B. and P.M. project administration.
Posted May 09, 2020.
Structural basis for active-site probes targeting Staphylococcus aureus serine hydrolase virulence factors
