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Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients

Paul F. McKay, Kai Hu, Anna K. Blakney, Karnyart Samnuan, Clément R. Bouton, Paul Rogers, Krunal Polra, Paulo J.C. Lin, Christopher Barbosa, Ying Tam, Robin J. Shattock
doi: https://doi.org/10.1101/2020.04.22.055608
Paul F. McKay
1Department of Infectious Diseases, Imperial College London, Norfolk Place, London, United Kingdom W2 1PG
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Kai Hu
1Department of Infectious Diseases, Imperial College London, Norfolk Place, London, United Kingdom W2 1PG
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Anna K. Blakney
1Department of Infectious Diseases, Imperial College London, Norfolk Place, London, United Kingdom W2 1PG
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Karnyart Samnuan
1Department of Infectious Diseases, Imperial College London, Norfolk Place, London, United Kingdom W2 1PG
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Clément R. Bouton
1Department of Infectious Diseases, Imperial College London, Norfolk Place, London, United Kingdom W2 1PG
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Paul Rogers
1Department of Infectious Diseases, Imperial College London, Norfolk Place, London, United Kingdom W2 1PG
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Krunal Polra
1Department of Infectious Diseases, Imperial College London, Norfolk Place, London, United Kingdom W2 1PG
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Paulo J.C. Lin
2Acuitas Therapeutics, Vancouver, British Columbia, Canada, V6T 1Z3
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Christopher Barbosa
2Acuitas Therapeutics, Vancouver, British Columbia, Canada, V6T 1Z3
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Ying Tam
2Acuitas Therapeutics, Vancouver, British Columbia, Canada, V6T 1Z3
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Robin J. Shattock
1Department of Infectious Diseases, Imperial College London, Norfolk Place, London, United Kingdom W2 1PG
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  • For correspondence: r.shattock@imperial.ac.uk
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Posted April 25, 2020.
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Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients
Paul F. McKay, Kai Hu, Anna K. Blakney, Karnyart Samnuan, Clément R. Bouton, Paul Rogers, Krunal Polra, Paulo J.C. Lin, Christopher Barbosa, Ying Tam, Robin J. Shattock
bioRxiv 2020.04.22.055608; doi: https://doi.org/10.1101/2020.04.22.055608
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Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients
Paul F. McKay, Kai Hu, Anna K. Blakney, Karnyart Samnuan, Clément R. Bouton, Paul Rogers, Krunal Polra, Paulo J.C. Lin, Christopher Barbosa, Ying Tam, Robin J. Shattock
bioRxiv 2020.04.22.055608; doi: https://doi.org/10.1101/2020.04.22.055608

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