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Coronavirus surveillance of wildlife in the Lao People’s Democratic Republic detects viral RNA in rodents

David J. McIver, Soubanh Silithammavong, Watthana Theppangna, Amethyst Gillis, Bounlom Douangngeun, Kongsy Khammavong, Sinpakone Singhalath, Veasna Duong, Philippe Buchy, Sarah H. Olson, Lucy Keatts, Amanda E. Fine, Zoe Greatorex, Martin Gilbert, Matthew LeBreton, Karen Saylors, Damien O. Joly, Edward M. Rubin, Christian E. Lange
doi: https://doi.org/10.1101/2020.04.22.056218
David J. McIver
1Metabiota Inc., Nanaimo BC, Canada
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Soubanh Silithammavong
2Wildlife Conservation Society, Laos Program, Vientiane, Lao PDR
3Metabiota Inc., San Francisco CA, USA
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Watthana Theppangna
4National Animal Health Laboratory, Department of Livestock and Fisheries, Vientiane, Lao PDR
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Amethyst Gillis
3Metabiota Inc., San Francisco CA, USA
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Bounlom Douangngeun
4National Animal Health Laboratory, Department of Livestock and Fisheries, Vientiane, Lao PDR
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Kongsy Khammavong
2Wildlife Conservation Society, Laos Program, Vientiane, Lao PDR
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Sinpakone Singhalath
2Wildlife Conservation Society, Laos Program, Vientiane, Lao PDR
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Veasna Duong
5Institut Pasteur du Cambodge, Virology Unit, Phnom Penh, Cambodia
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Philippe Buchy
5Institut Pasteur du Cambodge, Virology Unit, Phnom Penh, Cambodia
6GlaxoSmithKline Vaccines R&D, Greater China & Intercontinental
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Sarah H. Olson
7Wildlife Conservation Society, Health Program, Bronx NY, USA
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Lucy Keatts
7Wildlife Conservation Society, Health Program, Bronx NY, USA
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Amanda E. Fine
7Wildlife Conservation Society, Health Program, Bronx NY, USA
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Zoe Greatorex
7Wildlife Conservation Society, Health Program, Bronx NY, USA
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Martin Gilbert
7Wildlife Conservation Society, Health Program, Bronx NY, USA
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Matthew LeBreton
8Mosaic, Yaoundé, Cameroon
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Karen Saylors
3Metabiota Inc., San Francisco CA, USA
9Labyrinth Global Health, Inc., St. Petersburg, FL, USA
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Damien O. Joly
1Metabiota Inc., Nanaimo BC, Canada
2Wildlife Conservation Society, Laos Program, Vientiane, Lao PDR
10British Columbia Ministry of Environment and Climate Change Strategy, Victoria BC, Canada
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Edward M. Rubin
3Metabiota Inc., San Francisco CA, USA
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Christian E. Lange
1Metabiota Inc., Nanaimo BC, Canada
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  • For correspondence: clange_virology@gmx.de
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Abstract

Coronaviruses can become zoonotic as in the case of COVID-19, and hunting, sale, and consumption of wild animals in Southeast Asia facilitates an increased risk for such incidents. We sampled and tested rodents (851) and other mammals, and found Betacoronavirus RNA in 12 rodents. The sequences belong to two separate genetic clusters, and relate closely to known rodent coronaviruses detected in the region, and distantly to human coronaviruses OC43 and HKU1. Considering close human-wildlife contact with many species in and beyond the region, a better understanding of virus diversity is urgently needed for the mitigation of future risks.

Competing Interest Statement

Philippe Buchy is currently an employee of GSK vaccines.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 23, 2020.
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Coronavirus surveillance of wildlife in the Lao People’s Democratic Republic detects viral RNA in rodents
David J. McIver, Soubanh Silithammavong, Watthana Theppangna, Amethyst Gillis, Bounlom Douangngeun, Kongsy Khammavong, Sinpakone Singhalath, Veasna Duong, Philippe Buchy, Sarah H. Olson, Lucy Keatts, Amanda E. Fine, Zoe Greatorex, Martin Gilbert, Matthew LeBreton, Karen Saylors, Damien O. Joly, Edward M. Rubin, Christian E. Lange
bioRxiv 2020.04.22.056218; doi: https://doi.org/10.1101/2020.04.22.056218
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Coronavirus surveillance of wildlife in the Lao People’s Democratic Republic detects viral RNA in rodents
David J. McIver, Soubanh Silithammavong, Watthana Theppangna, Amethyst Gillis, Bounlom Douangngeun, Kongsy Khammavong, Sinpakone Singhalath, Veasna Duong, Philippe Buchy, Sarah H. Olson, Lucy Keatts, Amanda E. Fine, Zoe Greatorex, Martin Gilbert, Matthew LeBreton, Karen Saylors, Damien O. Joly, Edward M. Rubin, Christian E. Lange
bioRxiv 2020.04.22.056218; doi: https://doi.org/10.1101/2020.04.22.056218

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