Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

ACE2 polymorphisms and individual susceptibility to SARS-CoV-2 infection: insights from an in silico study

Matteo Calcagnile, Patricia Forgez, Antonio Iannelli, Cecilia Bucci, Marco Alifano, Pietro Alifano
doi: https://doi.org/10.1101/2020.04.23.057042
Matteo Calcagnile
1Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Patricia Forgez
2INSERM UMR-S 1124 T3S, Eq 5 CELLULAR HOMEOSTASIS, CANCER and THERAPY, University of Paris, Campus Saint Germain, Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Antonio Iannelli
3Digestive Disease Department, Archet 2 Hospital, Nice University Hospital, University of Nice Côte d’Azur, Nice, France
4INSERM,U1065, Team 8 “Hepatic complications of obesity”, University Nice Côte d’Azur, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cecilia Bucci
1Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marco Alifano
5Thoracic Surgery Department, Cochin Hospital, APHP Centre, University of Paris, France
6INSERM U1138 Team «Cancer, Immune Control, and Escape», Cordeliers Research Center, University of Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: pietro.alifano@unisalento.it marco.alifano@aphp.fr
Pietro Alifano
1Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: pietro.alifano@unisalento.it marco.alifano@aphp.fr
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

The current SARS covid-19 epidemic spread appears to be influenced by ethnical, geographical and sex-related factors that may involve genetic susceptibility to diseases. Similar to SARS-CoV, SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as a receptor to invade cells, notably type II alveolar epithelial cells. Importantly, ACE2 gene is highly polymorphic. Here we have used in silico tools to analyze the possible impact of ACE2 single-nucleotide polymorphisms (SNPs) on the interaction with SARS-CoV-2 spike glycoprotein. We found that S19P (common in African people) and K26R (common in European people) were, among the most diffused SNPs worldwide, the only two SNPs that were able to potentially affect the interaction of ACE2 with SARS-CoV-2 spike. FireDock simulations demonstrated that while S19P may decrease, K26R might increase the ACE2 affinity for SARS-CoV-2 Spike. This finding suggests that the S19P may genetically protect, and K26R may predispose to more severe SARS-CoV-2 disease.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted April 24, 2020.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
ACE2 polymorphisms and individual susceptibility to SARS-CoV-2 infection: insights from an in silico study
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
ACE2 polymorphisms and individual susceptibility to SARS-CoV-2 infection: insights from an in silico study
Matteo Calcagnile, Patricia Forgez, Antonio Iannelli, Cecilia Bucci, Marco Alifano, Pietro Alifano
bioRxiv 2020.04.23.057042; doi: https://doi.org/10.1101/2020.04.23.057042
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
ACE2 polymorphisms and individual susceptibility to SARS-CoV-2 infection: insights from an in silico study
Matteo Calcagnile, Patricia Forgez, Antonio Iannelli, Cecilia Bucci, Marco Alifano, Pietro Alifano
bioRxiv 2020.04.23.057042; doi: https://doi.org/10.1101/2020.04.23.057042

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Microbiology
Subject Areas
All Articles
  • Animal Behavior and Cognition (3586)
  • Biochemistry (7545)
  • Bioengineering (5495)
  • Bioinformatics (20729)
  • Biophysics (10294)
  • Cancer Biology (7950)
  • Cell Biology (11610)
  • Clinical Trials (138)
  • Developmental Biology (6586)
  • Ecology (10168)
  • Epidemiology (2065)
  • Evolutionary Biology (13578)
  • Genetics (9520)
  • Genomics (12817)
  • Immunology (7906)
  • Microbiology (19503)
  • Molecular Biology (7641)
  • Neuroscience (41982)
  • Paleontology (307)
  • Pathology (1254)
  • Pharmacology and Toxicology (2192)
  • Physiology (3259)
  • Plant Biology (7018)
  • Scientific Communication and Education (1293)
  • Synthetic Biology (1947)
  • Systems Biology (5418)
  • Zoology (1113)