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Differences in visually induced MEG oscillations reflect differences in deep cortical layer activity

View ORCID ProfileD. A. Pinotsis, View ORCID ProfileE. K. Miller
doi: https://doi.org/10.1101/2020.04.23.057406
D. A. Pinotsis
1Centre for Mathematical Neuroscience and Psychology and Department of Psychology, City —University of London, London EC1V 0HB, United Kingdom
2The Picower Institute for Learning & Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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  • For correspondence: pinotsis@mit.edu
E. K. Miller
2The Picower Institute for Learning & Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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Abstract

Neural activity is organized at multiple scales, ranging from the cellular to the whole brain level. Connecting neural dynamics at different scales is important for understanding brain pathology. Neurological diseases and disorders arise from interactions between factors that are expressed in multiple scales. Here, we suggest a new way to link microscopic and macroscopic dynamics through combinations of computational models. This exploits results from statistical decision theory and Bayesian inference. To validate our approach, we used two independent MEG datasets. In both, we found that variability in visually induced oscillations recorded from different people in simple visual perception tasks resulted from differences in the level of inhibition specific to deep cortical layers. This suggests differences in feedback to sensory areas and each subject’s hypotheses about sensations due to differences in their prior experience. Our approach provides a new link between non-invasive brain imaging data, laminar dynamics and top-down control.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted July 29, 2020.
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Differences in visually induced MEG oscillations reflect differences in deep cortical layer activity
D. A. Pinotsis, E. K. Miller
bioRxiv 2020.04.23.057406; doi: https://doi.org/10.1101/2020.04.23.057406
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Differences in visually induced MEG oscillations reflect differences in deep cortical layer activity
D. A. Pinotsis, E. K. Miller
bioRxiv 2020.04.23.057406; doi: https://doi.org/10.1101/2020.04.23.057406

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