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Circuits for integrating learnt and innate valences in the fly brain

View ORCID ProfileClaire Eschbach, View ORCID ProfileAkira Fushiki, View ORCID ProfileMichael Winding, Bruno Afonso, Ingrid V Andrade, View ORCID ProfileBenjamin T Cocanougher, View ORCID ProfileKatharina Eichler, Ruben Gepner, View ORCID ProfileGuangwei Si, View ORCID ProfileJavier Valdes-Aleman, View ORCID ProfileMarc Gershow, View ORCID ProfileGregory SXE Jefferis, James W Truman, Richard D Fetter, View ORCID ProfileAravinthan Samuel, View ORCID ProfileAlbert Cardona, View ORCID ProfileMarta Zlatic
doi: https://doi.org/10.1101/2020.04.23.058339
Claire Eschbach
1HHMI Janelia Research Campus, VA, USA
2Department of Zoology, University of Cambridge, UK
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  • For correspondence: mz209@cam.ac.uk
Akira Fushiki
1HHMI Janelia Research Campus, VA, USA
3Department of Neuroscience & Neurology, & Zuckerman Mind Brain Institute, Columbia University, NY, USA
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Michael Winding
1HHMI Janelia Research Campus, VA, USA
2Department of Zoology, University of Cambridge, UK
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  • ORCID record for Michael Winding
Bruno Afonso
1HHMI Janelia Research Campus, VA, USA
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Ingrid V Andrade
1HHMI Janelia Research Campus, VA, USA
4Department of Molecular, Cell and Developmental Biology, University California Los Angeles, CA, USA
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Benjamin T Cocanougher
1HHMI Janelia Research Campus, VA, USA
2Department of Zoology, University of Cambridge, UK
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  • ORCID record for Benjamin T Cocanougher
Katharina Eichler
1HHMI Janelia Research Campus, VA, USA
5Institute of Neurobiology, University of Puerto Rico Medical Science Campus, Puerto Rico
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  • ORCID record for Katharina Eichler
Ruben Gepner
6Department of Physics, New York University, NY, USA
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Guangwei Si
7Department of Physics, Harvard University, MA, USA
8Center for Brain Science, Harvard University, MA, USA
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  • ORCID record for Guangwei Si
Javier Valdes-Aleman
1HHMI Janelia Research Campus, VA, USA
4Department of Molecular, Cell and Developmental Biology, University California Los Angeles, CA, USA
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Marc Gershow
6Department of Physics, New York University, NY, USA
9Center for Neural Science, New York University, NY, USA
10Neuroscience Institute, New York University, NY, USA
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Gregory SXE Jefferis
2Department of Zoology, University of Cambridge, UK
11Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK
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James W Truman
1HHMI Janelia Research Campus, VA, USA
12Department of Biology, University of Washington, WA, USA
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Richard D Fetter
1HHMI Janelia Research Campus, VA, USA
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Aravinthan Samuel
7Department of Physics, Harvard University, MA, USA
8Center for Brain Science, Harvard University, MA, USA
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  • ORCID record for Aravinthan Samuel
Albert Cardona
1HHMI Janelia Research Campus, VA, USA
11Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK
13Department of Physiology, Development & Neuroscience, University of Cambridge, UK
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  • For correspondence: mz209@cam.ac.uk
Marta Zlatic
1HHMI Janelia Research Campus, VA, USA
2Department of Zoology, University of Cambridge, UK
11Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK
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  • For correspondence: mz209@cam.ac.uk
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Abstract

Animal behavior is shaped both by evolution and by individual experience. In many species parallel brain pathways are thought to encode innate and learnt behavior drives and as a result may link the same sensory cue to different actions if innate and learnt drives are in opposition. How these opposing drives are integrated into a single coherent action is not well understood. In insects, the Mushroom Body Output Neurons (MBONs) and the Lateral Horn Neurons (LHNs) are thought to provide the learnt and innate drives, respectively. However their patterns of convergence and the mechanisms by which their outputs are used to select actions are not well understood. We used electron microscopy reconstruction to comprehensively map the downstream targets of all MBONs in Drosophila larva and characterise their patterns of convergence with LHNs. We discovered convergence neurons that receive direct input from MBONs and LHNs and compare opposite behaviour drives. Functional imaging and optogenetic manipulation suggest these convergence neurons compute the overall predicted value of approaching or avoiding an odor and mediate action selection. Our study describes the circuit mechanisms allowing integration of opposing drives from parallel olfactory pathways.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵s second author

  • ↵§ joined supervision

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 24, 2020.
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Circuits for integrating learnt and innate valences in the fly brain
Claire Eschbach, Akira Fushiki, Michael Winding, Bruno Afonso, Ingrid V Andrade, Benjamin T Cocanougher, Katharina Eichler, Ruben Gepner, Guangwei Si, Javier Valdes-Aleman, Marc Gershow, Gregory SXE Jefferis, James W Truman, Richard D Fetter, Aravinthan Samuel, Albert Cardona, Marta Zlatic
bioRxiv 2020.04.23.058339; doi: https://doi.org/10.1101/2020.04.23.058339
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Circuits for integrating learnt and innate valences in the fly brain
Claire Eschbach, Akira Fushiki, Michael Winding, Bruno Afonso, Ingrid V Andrade, Benjamin T Cocanougher, Katharina Eichler, Ruben Gepner, Guangwei Si, Javier Valdes-Aleman, Marc Gershow, Gregory SXE Jefferis, James W Truman, Richard D Fetter, Aravinthan Samuel, Albert Cardona, Marta Zlatic
bioRxiv 2020.04.23.058339; doi: https://doi.org/10.1101/2020.04.23.058339

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