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In Lyl1-/- mice, adipose stem cell vascular niche impairment leads to premature development of fat tissues

Abid Hussain, Leila El Kebriti, Virginie Deleuze, Yaël Glasson, Nelly Pirot, Danièle Mathieu, Valérie Pinet
doi: https://doi.org/10.1101/2020.04.24.059683
Abid Hussain
1Institut de Génétique Moléculaire de Montpellier, Univ Montpellier, CNRS, Montpellier, France
2Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, Pakistan
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Leila El Kebriti
1Institut de Génétique Moléculaire de Montpellier, Univ Montpellier, CNRS, Montpellier, France
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Virginie Deleuze
1Institut de Génétique Moléculaire de Montpellier, Univ Montpellier, CNRS, Montpellier, France
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Yaël Glasson
3Réseau d’Histologie Expérimentale de Montpellier, BioCampus, UMS3426 CNRS-US009 INSERM-UM, Montpellier, France
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Nelly Pirot
3Réseau d’Histologie Expérimentale de Montpellier, BioCampus, UMS3426 CNRS-US009 INSERM-UM, Montpellier, France
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Danièle Mathieu
1Institut de Génétique Moléculaire de Montpellier, Univ Montpellier, CNRS, Montpellier, France
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Valérie Pinet
1Institut de Génétique Moléculaire de Montpellier, Univ Montpellier, CNRS, Montpellier, France
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  • For correspondence: valerie.pinet@igmm.cnrs.fr
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ABSTRACT

Lymphoblastic leukemia-derived sequence 1 (Lyl1) encodes a hematopoietic- and endothelial-specific transcriptional factor. Lyl1-deficient mice are viable, but they display mild hematopoietic and vascular defects. Here, we report that young Lyl1-/- mice exhibit transient obesity associated with general expansion of adipose tissues and unrelated to food intake. The increased fat tissue development in Lyl1-/- mice resulted from an earlier adipocyte differentiation of adipose stem cells (ASCs) through non-cell autonomous mechanisms. Specifically, we found that in Lyl1-/- mice, the vascular structures of adipose tissues are unstable, more prone to angiogenesis and, consequently, cannot maintain adipose progenitors in the niche vessel wall. Together, our data show that in Lyl1-/- mice, the impaired vascular compartment of the adipose niche promotes uncontrolled ASC activation and differentiation, leading to early adipocyte expansion and premature depletion of ASCs. Our study highlights the major structural role of the adipose tissue vascular niche in coordinating stem cell self-renewal and differentiation into adipocytes.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Funding information: This work was funded by the Association pour la Recherche sur le Cancer (ARC, France).

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 25, 2020.
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In Lyl1-/- mice, adipose stem cell vascular niche impairment leads to premature development of fat tissues
Abid Hussain, Leila El Kebriti, Virginie Deleuze, Yaël Glasson, Nelly Pirot, Danièle Mathieu, Valérie Pinet
bioRxiv 2020.04.24.059683; doi: https://doi.org/10.1101/2020.04.24.059683
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In Lyl1-/- mice, adipose stem cell vascular niche impairment leads to premature development of fat tissues
Abid Hussain, Leila El Kebriti, Virginie Deleuze, Yaël Glasson, Nelly Pirot, Danièle Mathieu, Valérie Pinet
bioRxiv 2020.04.24.059683; doi: https://doi.org/10.1101/2020.04.24.059683

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