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Quantification of Mouse Reach Kinematics as a Foundation for Mechanistic Interrogation of Motor Control

Matthew I. Becker, Dylan Calame, Julia Wrobel, Abigail L. Person
doi: https://doi.org/10.1101/2020.04.24.060533
Matthew I. Becker
1University of Colorado Neuroscience Graduate Program
2University of Colorado Medical Scientist Training Program
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Dylan Calame
1University of Colorado Neuroscience Graduate Program
2University of Colorado Medical Scientist Training Program
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Julia Wrobel
3Colorado School of Public Health, Department of Biostatistics and Informatics
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Abigail L. Person
4University of Colorado School of Medicine, Department of Physiology and Biophysics, Aurora CO 80045
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  • For correspondence: abigail.person@cuanschutz.edu
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Abstract

Mice use reaching movements to grasp and manipulate objects in their environment, similar to primates. Thus, many recent studies use mouse reach to uncover neural control mechanisms, but quantification of mouse reach kinematics remains lacking, limiting understanding. Here we implement several analytical frameworks, from basic kinematic relationships to statistical machine learning, to quantify mouse reach kinematics across freely-behaving and head-fixed conditions. Overall, we find that many canonical features of primate reaches are conserved in mice, with some notable differences. Our results highlight the decelerative phase of reach as important in driving successful outcome. Late-phase kinematic adjustments are yoked to mid-flight position and velocity of the limb, allowing dynamic correction of initial variability, with head-fixed reaches being less dependent on position. Furthermore, consecutive reaches exhibit positional error-correction but not hot-handedness, implying opponent regulation of motor variability. Overall, our results establish foundational mouse reach kinematics in the context of neuroscientific investigation.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 25, 2020.
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Quantification of Mouse Reach Kinematics as a Foundation for Mechanistic Interrogation of Motor Control
Matthew I. Becker, Dylan Calame, Julia Wrobel, Abigail L. Person
bioRxiv 2020.04.24.060533; doi: https://doi.org/10.1101/2020.04.24.060533
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Quantification of Mouse Reach Kinematics as a Foundation for Mechanistic Interrogation of Motor Control
Matthew I. Becker, Dylan Calame, Julia Wrobel, Abigail L. Person
bioRxiv 2020.04.24.060533; doi: https://doi.org/10.1101/2020.04.24.060533

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