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Coronavirus, as a source of pandemic pathogens

View ORCID ProfileT. Konishi
doi: https://doi.org/10.1101/2020.04.26.063032
T. Konishi
1Akita Prefectural University, Faculty of Bioresource Sciences
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  • For correspondence: konishi@akita-pu.ac.jp
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Abstract

The coronavirus and the influenza virus have similarities and differences. In order to comprehensively compare them, their genome sequencing data were examined by principal component analysis. Variations in coronavirus were smaller than those in a subclass of the influenza virus. In addition, differences among coronaviruses in a variety of hosts were small. These characteristics may have facilitated the infection of different hosts. Although many of the coronaviruses were more conservative, those repeatedly found among humans showed annual changes. If SARS-CoV-2 changes its genome like the Influenza H type, it will repeatedly spread every few years. In addition, the coronavirus family has many other candidates for subsequent pandemics.

Competing Interest Statement

The authors have declared no competing interest.

  • Abbreviations

    HCoV
    human coronavirus
    MERS
    Middle East respiratory syndrome
    ORF
    open reading frame
    PCA
    principal component analysis
    SARS
    severe acute respiratory syndrome
    SCoV2
    SARS-CoV-2
    TGEV
    transmissible gastroenteritis virus of swine
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    Posted May 16, 2020.
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    Coronavirus, as a source of pandemic pathogens
    T. Konishi
    bioRxiv 2020.04.26.063032; doi: https://doi.org/10.1101/2020.04.26.063032
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    Coronavirus, as a source of pandemic pathogens
    T. Konishi
    bioRxiv 2020.04.26.063032; doi: https://doi.org/10.1101/2020.04.26.063032

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