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Role of 1’-Ribose Cyano Substitution for Remdesivir to Effectively Inhibit both Nucleotide Addition and Proofreading in SARS-CoV-2 Viral RNA Replication

Lu Zhang, Dong Zhang, Congmin Yuan, Xiaowei Wang, Yongfang Li, Xilin Jia, Xin Gao, Hui-Ling Yen, Peter Pak-Hang Cheung, View ORCID ProfileXuhui Huang
doi: https://doi.org/10.1101/2020.04.27.063859
Lu Zhang
1State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, China
2University of Chinese Academy of Sciences, Beijing, China
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  • For correspondence: luzhang@fjirsm.ac.cn hyen@hku.hk ppcheung@ust.hk xuhuihuang@ust.hk
Dong Zhang
1State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, China
2University of Chinese Academy of Sciences, Beijing, China
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Congmin Yuan
3Department of Chemistry, Centre of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong
4The Hong Kong University of Science and Technology-Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518057, China
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Xiaowei Wang
3Department of Chemistry, Centre of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong
4The Hong Kong University of Science and Technology-Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518057, China
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Yongfang Li
1State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, China
2University of Chinese Academy of Sciences, Beijing, China
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Xilin Jia
1State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, China
2University of Chinese Academy of Sciences, Beijing, China
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Xin Gao
5Computational Bioscience Research Center, Computer, Electrical and Mathematical Sciences Engineering Division, King Abdullah University of Science and Technology, Saudi Arabia
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Hui-Ling Yen
6School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong
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  • For correspondence: luzhang@fjirsm.ac.cn hyen@hku.hk ppcheung@ust.hk xuhuihuang@ust.hk
Peter Pak-Hang Cheung
3Department of Chemistry, Centre of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong
4The Hong Kong University of Science and Technology-Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518057, China
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  • For correspondence: luzhang@fjirsm.ac.cn hyen@hku.hk ppcheung@ust.hk xuhuihuang@ust.hk
Xuhui Huang
3Department of Chemistry, Centre of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong
4The Hong Kong University of Science and Technology-Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518057, China
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  • ORCID record for Xuhui Huang
  • For correspondence: luzhang@fjirsm.ac.cn hyen@hku.hk ppcheung@ust.hk xuhuihuang@ust.hk
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Article Information

doi 
https://doi.org/10.1101/2020.04.27.063859
History 
  • April 27, 2020.

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  • You are currently viewing Version 1 of this article (April 27, 2020 - 23:42).
  • Version 2 (July 10, 2020 - 08:42).
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Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Lu Zhang1,2,*,
  2. Dong Zhang1,2,
  3. Congmin Yuan3,4,
  4. Xiaowei Wang3,4,
  5. Yongfang Li1,2,
  6. Xilin Jia1,2,
  7. Xin Gao5,
  8. Hui-Ling Yen6,*,
  9. Peter Pak-Hang Cheung3,4,* and
  10. Xuhui Huang3,4,*
  1. 1State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, China
  2. 2University of Chinese Academy of Sciences, Beijing, China
  3. 3Department of Chemistry, Centre of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong
  4. 4The Hong Kong University of Science and Technology-Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518057, China
  5. 5Computational Bioscience Research Center, Computer, Electrical and Mathematical Sciences Engineering Division, King Abdullah University of Science and Technology, Saudi Arabia
  6. 6School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong
  1. ↵*correspondence could be addressed to: luzhang{at}fjirsm.ac.cn (L. Z.) or hyen{at}hku.hk (H.-L. Y.) or ppcheung{at}ust.hk (P. P.-H. C.) or xuhuihuang{at}ust.hk (X. H.)
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Role of 1’-Ribose Cyano Substitution for Remdesivir to Effectively Inhibit both Nucleotide Addition and Proofreading in SARS-CoV-2 Viral RNA Replication
Lu Zhang, Dong Zhang, Congmin Yuan, Xiaowei Wang, Yongfang Li, Xilin Jia, Xin Gao, Hui-Ling Yen, Peter Pak-Hang Cheung, Xuhui Huang
bioRxiv 2020.04.27.063859; doi: https://doi.org/10.1101/2020.04.27.063859
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Role of 1’-Ribose Cyano Substitution for Remdesivir to Effectively Inhibit both Nucleotide Addition and Proofreading in SARS-CoV-2 Viral RNA Replication
Lu Zhang, Dong Zhang, Congmin Yuan, Xiaowei Wang, Yongfang Li, Xilin Jia, Xin Gao, Hui-Ling Yen, Peter Pak-Hang Cheung, Xuhui Huang
bioRxiv 2020.04.27.063859; doi: https://doi.org/10.1101/2020.04.27.063859

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