A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness

T.J. Sego; Josua O. Aponte-Serrano; Juliano Ferrari Gianlupi; Samuel R. Heaps; Kira Breithaupt; Lutz Brusch; James M. Osborne; Ellen M. Quardokus; Richard K. Plemper; James A. Glazier

doi:10.1101/2020.04.27.064139

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A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness

T.J. Sego, Josua O. Aponte-Serrano, Juliano Ferrari Gianlupi, Samuel R. Heaps, Kira Breithaupt, Lutz Brusch, James M. Osborne, Ellen M. Quardokus, Richard K. Plemper, James A. Glazier

doi: https://doi.org/10.1101/2020.04.27.064139

T.J. Sego

1Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA

2Biocomplexity Institute, Indiana University, Bloomington, IN, USA

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Josua O. Aponte-Serrano

1Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA

2Biocomplexity Institute, Indiana University, Bloomington, IN, USA

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Juliano Ferrari Gianlupi

1Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA

2Biocomplexity Institute, Indiana University, Bloomington, IN, USA

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Samuel R. Heaps

1Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA

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Kira Breithaupt

1Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA

3Cognitive Science Program, Indiana University, Bloomington, IN, USA

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Lutz Brusch

4Center for Information Services and High Performance Computing (ZIH), Technische Universität Dresden, Germany

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James M. Osborne

5School of Mathematics and Statistics, University of Melbourne, Melbourne, 3010, Australia

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Ellen M. Quardokus

1Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA

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Richard K. Plemper

6Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA

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James A. Glazier

1Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA

2Biocomplexity Institute, Indiana University, Bloomington, IN, USA

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For correspondence: glazier@indiana.edu

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A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness

T.J. Sego, Josua O. Aponte-Serrano, Juliano Ferrari Gianlupi, Samuel R. Heaps, Kira Breithaupt, Lutz Brusch, James M. Osborne, Ellen M. Quardokus, Richard K. Plemper, James A. Glazier

bioRxiv 2020.04.27.064139; doi: https://doi.org/10.1101/2020.04.27.064139

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T.J. Sego, Josua O. Aponte-Serrano, Juliano Ferrari Gianlupi, Samuel R. Heaps, Kira Breithaupt, Lutz Brusch, James M. Osborne, Ellen M. Quardokus, Richard K. Plemper, James A. Glazier

bioRxiv 2020.04.27.064139; doi: https://doi.org/10.1101/2020.04.27.064139

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