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SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins
View ORCID ProfileCourtney J. Mycroft-West, View ORCID ProfileDunhao Su, View ORCID ProfileYong Li, View ORCID ProfileScott E. Guimond, View ORCID ProfileTimothy R. Rudd, View ORCID ProfileStefano Elli, View ORCID ProfileGavin Miller, View ORCID ProfileQuentin M. Nunes, Patricia Procter, View ORCID ProfileAntonella Bisio, View ORCID ProfileNicholas R. Forsyth, View ORCID ProfileJeremy E. Turnbull, View ORCID ProfileMarco Guerrini, View ORCID ProfileDavid G. Fernig, View ORCID ProfileEdwin A. Yates, View ORCID ProfileMarcelo A. Lima, View ORCID ProfileMark A. Skidmore
doi: https://doi.org/10.1101/2020.04.29.068486
Courtney J. Mycroft-West
1Molecular & Structural Biosciences, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire, ST5 5BG, UK
Dunhao Su
2Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK
Yong Li
2Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK
Scott E. Guimond
3School of Medicine, Keele University, Newcastle-Under-Lyme, Staffordshire, ST5 5BG, UK
Timothy R. Rudd
4National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, EN6 3QG, UK
Stefano Elli
5Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Via G. Colombo 81, 20133, Milan, Italy
Gavin Miller
6School of Chemistry, Keele University, Newcastle-Under-Lyme, Staffordshire, ST5 5BG, UK
Quentin M. Nunes
7Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3BX, UK
Patricia Procter
1Molecular & Structural Biosciences, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire, ST5 5BG, UK
Antonella Bisio
5Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Via G. Colombo 81, 20133, Milan, Italy
Nicholas R. Forsyth
8Guy Hilton Research Centre, School of Pharmacy and Bioengineering, Keele University, Hartshill, Stoke-on-Trent, ST4 7QB
Jeremy E. Turnbull
2Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK
Marco Guerrini
5Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Via G. Colombo 81, 20133, Milan, Italy
David G. Fernig
2Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK
Edwin A. Yates
2Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK
1Molecular & Structural Biosciences, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire, ST5 5BG, UK
Marcelo A. Lima
1Molecular & Structural Biosciences, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire, ST5 5BG, UK
Mark A. Skidmore
1Molecular & Structural Biosciences, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire, ST5 5BG, UK
2Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK
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Posted April 29, 2020.
SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins
Courtney J. Mycroft-West, Dunhao Su, Yong Li, Scott E. Guimond, Timothy R. Rudd, Stefano Elli, Gavin Miller, Quentin M. Nunes, Patricia Procter, Antonella Bisio, Nicholas R. Forsyth, Jeremy E. Turnbull, Marco Guerrini, David G. Fernig, Edwin A. Yates, Marcelo A. Lima, Mark A. Skidmore
bioRxiv 2020.04.29.068486; doi: https://doi.org/10.1101/2020.04.29.068486
SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins
Courtney J. Mycroft-West, Dunhao Su, Yong Li, Scott E. Guimond, Timothy R. Rudd, Stefano Elli, Gavin Miller, Quentin M. Nunes, Patricia Procter, Antonella Bisio, Nicholas R. Forsyth, Jeremy E. Turnbull, Marco Guerrini, David G. Fernig, Edwin A. Yates, Marcelo A. Lima, Mark A. Skidmore
bioRxiv 2020.04.29.068486; doi: https://doi.org/10.1101/2020.04.29.068486
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