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Heat inactivation of the Severe Acute Respiratory Syndrome Coronavirus 2

View ORCID ProfileChristophe Batéjat, Quentin Grassin, View ORCID ProfileJean-Claude Manuguerra, View ORCID ProfileIndia Leclercq
doi: https://doi.org/10.1101/2020.05.01.067769
Christophe Batéjat
1Institut Pasteur, Unité Environnement et Risques Infectieux, Cellule d’Intervention Biologique d’Urgence (CIBU), 28 rue du Dr Roux, Paris, France
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Quentin Grassin
1Institut Pasteur, Unité Environnement et Risques Infectieux, Cellule d’Intervention Biologique d’Urgence (CIBU), 28 rue du Dr Roux, Paris, France
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Jean-Claude Manuguerra
1Institut Pasteur, Unité Environnement et Risques Infectieux, Cellule d’Intervention Biologique d’Urgence (CIBU), 28 rue du Dr Roux, Paris, France
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India Leclercq
1Institut Pasteur, Unité Environnement et Risques Infectieux, Cellule d’Intervention Biologique d’Urgence (CIBU), 28 rue du Dr Roux, Paris, France
2Université de Paris, Cellule Pasteur, 28 rue du Dr Roux F-75015 Paris, France
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  • For correspondence: leclercqi@yahoo.fr
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Abstract

Supernatants of cells infected with SARS-CoV-2, nasopharyngeal and sera samples containing SARS-CoV-2 were submitted to heat inactivation for various periods of time, ranging from 30 seconds to 60 minutes. Our results showed that SARS-CoV-2 could be inactivated in less than 30 minutes, 15 minutes and 3 minutes at 56°C, 65°C and 95°C respectively. These data could help laboratory workers to improve their protocols with handling of the virus in biosafety conditions.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 01, 2020.
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Heat inactivation of the Severe Acute Respiratory Syndrome Coronavirus 2
Christophe Batéjat, Quentin Grassin, Jean-Claude Manuguerra, India Leclercq
bioRxiv 2020.05.01.067769; doi: https://doi.org/10.1101/2020.05.01.067769
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Heat inactivation of the Severe Acute Respiratory Syndrome Coronavirus 2
Christophe Batéjat, Quentin Grassin, Jean-Claude Manuguerra, India Leclercq
bioRxiv 2020.05.01.067769; doi: https://doi.org/10.1101/2020.05.01.067769

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