New Results
Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease
View ORCID ProfileSebastian Günther, View ORCID ProfilePatrick Y. A. Reinke, Dominik Oberthuer, Oleksandr Yefanov, Helen Ginn, Susanne Meier, Thomas J. Lane, Kristina Lorenzen, Luca Gelisio, Wolfgang Brehm, Illona Dunkel, Martin Domaracky, Sofiane Saouane, Julia Lieske, Christiane Ehrt, Faisal Koua, Alexandra Tolstikova, View ORCID ProfileThomas A. White, Michael Groessler, Holger Fleckenstein, Fabian Trost, Marina Galchenkova, Yaroslav Gevorkov, Chufeng Li, Salah Awel, Ariana Peck, P. Lourdu Xavier, Miriam Barthelmess, Frank Schlünzen, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Sven Falke, Bruno Alves Franca, Martin Schwinzer, Hévila Brognaro, Brandon Seychell, Henry Gieseler, Diogo Melo, Jo J. Zaitsev-Doyle, Brenna Norton-Baker, Juraj Knoska, Gisel Esperanza, Aida Rahmani Mashhour, Filip Guicking, Vincent Hennicke, Pontus Fischer, Cromarte Rogers, Diana C. F. Monteiro, Johanna Hakanpää, Jan Meyer, Heshmat Noei, Phil Gribbon, Bernhard Ellinger, Maria Kuzikov, Markus Wolf, Linlin Zhang, Xinyuanyuan Sun, Jonathan Pletzer-Zelgert, Jan Wollenhaupt, Christian Feiler, Manfred Weiss, Eike-Christian Schulz, Pedram Mehrabi, Christina Schmidt, Robin Schubert, Huijong Han, Boris Krichel, Yaiza Fernández-García, Beatriz Escudero-Pérez, Stephan Günther, Dusan Turk, Charlotte Uetrecht, Tobias Beck, Henning Tidow, Ashwin Chari, Andrea Zaliani, Matthias Rarey, Russell Cox, Rolf Hilgenfeld, Henry N. Chapman, Arwen R. Pearson, Christian Betzel, Alke Meents
doi: https://doi.org/10.1101/2020.05.02.043554
Sebastian Günther
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Patrick Y. A. Reinke
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Dominik Oberthuer
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Oleksandr Yefanov
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Helen Ginn
2Diamond Light Source Ltd. Diamond House, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK
Susanne Meier
3Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany
4Universität Hamburg, Institut für Nanostruktur- und Festkörperphysik, Luruper Chaussee 149, 22761 Hamburg, Germany
Thomas J. Lane
5Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California, USA
Kristina Lorenzen
6European XFEL GmbH. Holzkoppel 4, 22869 Schenefeld, Germany
Luca Gelisio
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Wolfgang Brehm
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Illona Dunkel
7Max Planck Institute for Molecular Genetics, Ihnestraße 63-73, 14195 Berlin, Germany
Martin Domaracky
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Sofiane Saouane
8Deutsches Elektronen Synchrotron (DESY), Photon Science, Notkestrasse 85, 22607, Hamburg, Germany
Julia Lieske
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Christiane Ehrt
9Universität Hamburg, Center for Bioinformatics, Bundesstr. 43, 20146 Hamburg, Germany
Faisal Koua
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Alexandra Tolstikova
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Thomas A. White
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Michael Groessler
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Holger Fleckenstein
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Fabian Trost
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Marina Galchenkova
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Yaroslav Gevorkov
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
10Vision Systems, Hamburg University of Technology, 21071 Hamburg, Germany
Chufeng Li
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Salah Awel
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Ariana Peck
11Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA
P. Lourdu Xavier
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
12Max Planck Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, 22761 Hamburg, Germany
Miriam Barthelmess
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Frank Schlünzen
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Nadine Werner
13Universität Hamburg, Department of Chemistry, Institute of Biochemistry and Molecular Biology and Laboratory for Structural Biology of Infection and Inflammation, c/o DESY, 22607 Hamburg, Germany
Hina Andaleeb
13Universität Hamburg, Department of Chemistry, Institute of Biochemistry and Molecular Biology and Laboratory for Structural Biology of Infection and Inflammation, c/o DESY, 22607 Hamburg, Germany
Najeeb Ullah
13Universität Hamburg, Department of Chemistry, Institute of Biochemistry and Molecular Biology and Laboratory for Structural Biology of Infection and Inflammation, c/o DESY, 22607 Hamburg, Germany
Sven Falke
13Universität Hamburg, Department of Chemistry, Institute of Biochemistry and Molecular Biology and Laboratory for Structural Biology of Infection and Inflammation, c/o DESY, 22607 Hamburg, Germany
Bruno Alves Franca
13Universität Hamburg, Department of Chemistry, Institute of Biochemistry and Molecular Biology and Laboratory for Structural Biology of Infection and Inflammation, c/o DESY, 22607 Hamburg, Germany
Martin Schwinzer
13Universität Hamburg, Department of Chemistry, Institute of Biochemistry and Molecular Biology and Laboratory for Structural Biology of Infection and Inflammation, c/o DESY, 22607 Hamburg, Germany
Hévila Brognaro
13Universität Hamburg, Department of Chemistry, Institute of Biochemistry and Molecular Biology and Laboratory for Structural Biology of Infection and Inflammation, c/o DESY, 22607 Hamburg, Germany
Brandon Seychell
14Universität Hamburg, Department of Chemistry, Institute of Physical Chemistry, Grindelallee 117, 20146 Hamburg, Germany
Henry Gieseler
3Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany
4Universität Hamburg, Institut für Nanostruktur- und Festkörperphysik, Luruper Chaussee 149, 22761 Hamburg, Germany
Diogo Melo
3Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany
4Universität Hamburg, Institut für Nanostruktur- und Festkörperphysik, Luruper Chaussee 149, 22761 Hamburg, Germany
Jo J. Zaitsev-Doyle
3Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany
4Universität Hamburg, Institut für Nanostruktur- und Festkörperphysik, Luruper Chaussee 149, 22761 Hamburg, Germany
Brenna Norton-Baker
12Max Planck Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, 22761 Hamburg, Germany
Juraj Knoska
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Gisel Esperanza
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Aida Rahmani Mashhour
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Filip Guicking
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Vincent Hennicke
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Pontus Fischer
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Cromarte Rogers
3Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany
4Universität Hamburg, Institut für Nanostruktur- und Festkörperphysik, Luruper Chaussee 149, 22761 Hamburg, Germany
Diana C. F. Monteiro
15Hauptmann Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY, 14203, USA
Johanna Hakanpää
8Deutsches Elektronen Synchrotron (DESY), Photon Science, Notkestrasse 85, 22607, Hamburg, Germany
Jan Meyer
8Deutsches Elektronen Synchrotron (DESY), Photon Science, Notkestrasse 85, 22607, Hamburg, Germany
Heshmat Noei
8Deutsches Elektronen Synchrotron (DESY), Photon Science, Notkestrasse 85, 22607, Hamburg, Germany
Phil Gribbon
16Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), screening port, Schnackenburgallee 114, 22525 Hamburg, Germany
Bernhard Ellinger
16Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), screening port, Schnackenburgallee 114, 22525 Hamburg, Germany
Maria Kuzikov
16Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), screening port, Schnackenburgallee 114, 22525 Hamburg, Germany
Markus Wolf
16Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), screening port, Schnackenburgallee 114, 22525 Hamburg, Germany
Linlin Zhang
17Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, 23562 Lübeck, Germany
18German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany
Xinyuanyuan Sun
17Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, 23562 Lübeck, Germany
18German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany
Jonathan Pletzer-Zelgert
9Universität Hamburg, Center for Bioinformatics, Bundesstr. 43, 20146 Hamburg, Germany
Jan Wollenhaupt
19Helmholtz Zentrum Berlin, Hahn-Meitner-Platz 1, 14109 Berlin, Germany
Christian Feiler
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Manfred Weiss
19Helmholtz Zentrum Berlin, Hahn-Meitner-Platz 1, 14109 Berlin, Germany
Eike-Christian Schulz
12Max Planck Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, 22761 Hamburg, Germany
Pedram Mehrabi
12Max Planck Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, 22761 Hamburg, Germany
Christina Schmidt
6European XFEL GmbH. Holzkoppel 4, 22869 Schenefeld, Germany
Robin Schubert
6European XFEL GmbH. Holzkoppel 4, 22869 Schenefeld, Germany
Huijong Han
6European XFEL GmbH. Holzkoppel 4, 22869 Schenefeld, Germany
Boris Krichel
20Dynamics of Viral Structures, Heinrich-Pette-Institut, Leibniz-Institut für Experimentelle Virologie, Martinistraße 52, 20251 Hamburg, Germany
Yaiza Fernández-García
21Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Straße 74, 20359 Hamburg, Germany
Beatriz Escudero-Pérez
21Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Straße 74, 20359 Hamburg, Germany
Stephan Günther
21Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Straße 74, 20359 Hamburg, Germany
Dusan Turk
22Department of Biochemistry & Molecular & Structural Biology, Jozef Stefan Institute, Jamova 39, 1 000 Ljubljana, Slovenia
23Centre of excellence for Integrated Approaches in Chemistry and Biology of Proteins (CIPKEBIP), Jamova 39, 1 000 Ljubljana,Slovenia
Charlotte Uetrecht
20Dynamics of Viral Structures, Heinrich-Pette-Institut, Leibniz-Institut für Experimentelle Virologie, Martinistraße 52, 20251 Hamburg, Germany
Tobias Beck
3Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany
14Universität Hamburg, Department of Chemistry, Institute of Physical Chemistry, Grindelallee 117, 20146 Hamburg, Germany
Henning Tidow
3Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany
24Universität Hamburg, Department of Chemistry, Institute of Biochemistry and Molecular Biology, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany
Ashwin Chari
25Department of Structural Dynamics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany
Andrea Zaliani
16Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), screening port, Schnackenburgallee 114, 22525 Hamburg, Germany
Matthias Rarey
9Universität Hamburg, Center for Bioinformatics, Bundesstr. 43, 20146 Hamburg, Germany
Russell Cox
26Institute for Organic Chemistry and BMWZ, Leibniz University of Hannover, Schneiderberg 38, 30167 Hannover, Germany
Rolf Hilgenfeld
18German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany
27Laboratory for Antiviral Chemotherapy, Institute of Chemistry & Metabolomics and Institute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
Henry N. Chapman
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
3Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany
Arwen R. Pearson
3Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany
4Universität Hamburg, Institut für Nanostruktur- und Festkörperphysik, Luruper Chaussee 149, 22761 Hamburg, Germany
Christian Betzel
3Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany
13Universität Hamburg, Department of Chemistry, Institute of Biochemistry and Molecular Biology and Laboratory for Structural Biology of Infection and Inflammation, c/o DESY, 22607 Hamburg, Germany
Alke Meents
1Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
Article usage
Posted May 04, 2020.
Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease
Sebastian Günther, Patrick Y. A. Reinke, Dominik Oberthuer, Oleksandr Yefanov, Helen Ginn, Susanne Meier, Thomas J. Lane, Kristina Lorenzen, Luca Gelisio, Wolfgang Brehm, Illona Dunkel, Martin Domaracky, Sofiane Saouane, Julia Lieske, Christiane Ehrt, Faisal Koua, Alexandra Tolstikova, Thomas A. White, Michael Groessler, Holger Fleckenstein, Fabian Trost, Marina Galchenkova, Yaroslav Gevorkov, Chufeng Li, Salah Awel, Ariana Peck, P. Lourdu Xavier, Miriam Barthelmess, Frank Schlünzen, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Sven Falke, Bruno Alves Franca, Martin Schwinzer, Hévila Brognaro, Brandon Seychell, Henry Gieseler, Diogo Melo, Jo J. Zaitsev-Doyle, Brenna Norton-Baker, Juraj Knoska, Gisel Esperanza, Aida Rahmani Mashhour, Filip Guicking, Vincent Hennicke, Pontus Fischer, Cromarte Rogers, Diana C. F. Monteiro, Johanna Hakanpää, Jan Meyer, Heshmat Noei, Phil Gribbon, Bernhard Ellinger, Maria Kuzikov, Markus Wolf, Linlin Zhang, Xinyuanyuan Sun, Jonathan Pletzer-Zelgert, Jan Wollenhaupt, Christian Feiler, Manfred Weiss, Eike-Christian Schulz, Pedram Mehrabi, Christina Schmidt, Robin Schubert, Huijong Han, Boris Krichel, Yaiza Fernández-García, Beatriz Escudero-Pérez, Stephan Günther, Dusan Turk, Charlotte Uetrecht, Tobias Beck, Henning Tidow, Ashwin Chari, Andrea Zaliani, Matthias Rarey, Russell Cox, Rolf Hilgenfeld, Henry N. Chapman, Arwen R. Pearson, Christian Betzel, Alke Meents
bioRxiv 2020.05.02.043554; doi: https://doi.org/10.1101/2020.05.02.043554
Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease
Sebastian Günther, Patrick Y. A. Reinke, Dominik Oberthuer, Oleksandr Yefanov, Helen Ginn, Susanne Meier, Thomas J. Lane, Kristina Lorenzen, Luca Gelisio, Wolfgang Brehm, Illona Dunkel, Martin Domaracky, Sofiane Saouane, Julia Lieske, Christiane Ehrt, Faisal Koua, Alexandra Tolstikova, Thomas A. White, Michael Groessler, Holger Fleckenstein, Fabian Trost, Marina Galchenkova, Yaroslav Gevorkov, Chufeng Li, Salah Awel, Ariana Peck, P. Lourdu Xavier, Miriam Barthelmess, Frank Schlünzen, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Sven Falke, Bruno Alves Franca, Martin Schwinzer, Hévila Brognaro, Brandon Seychell, Henry Gieseler, Diogo Melo, Jo J. Zaitsev-Doyle, Brenna Norton-Baker, Juraj Knoska, Gisel Esperanza, Aida Rahmani Mashhour, Filip Guicking, Vincent Hennicke, Pontus Fischer, Cromarte Rogers, Diana C. F. Monteiro, Johanna Hakanpää, Jan Meyer, Heshmat Noei, Phil Gribbon, Bernhard Ellinger, Maria Kuzikov, Markus Wolf, Linlin Zhang, Xinyuanyuan Sun, Jonathan Pletzer-Zelgert, Jan Wollenhaupt, Christian Feiler, Manfred Weiss, Eike-Christian Schulz, Pedram Mehrabi, Christina Schmidt, Robin Schubert, Huijong Han, Boris Krichel, Yaiza Fernández-García, Beatriz Escudero-Pérez, Stephan Günther, Dusan Turk, Charlotte Uetrecht, Tobias Beck, Henning Tidow, Ashwin Chari, Andrea Zaliani, Matthias Rarey, Russell Cox, Rolf Hilgenfeld, Henry N. Chapman, Arwen R. Pearson, Christian Betzel, Alke Meents
bioRxiv 2020.05.02.043554; doi: https://doi.org/10.1101/2020.05.02.043554
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