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Microstimulation in the primary visual cortex: activity patterns and their relation to visual responses and evoked saccades

R. Oz, H. Edelman-Klapper, S. Nivinsky-Margalit, H. Slovin
doi: https://doi.org/10.1101/2020.05.03.072322
R. Oz
1The Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel 5290002
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H. Edelman-Klapper
1The Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel 5290002
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S. Nivinsky-Margalit
1The Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel 5290002
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H. Slovin
1The Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel 5290002
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  • For correspondence: hamutal.slovin@biu.ac.il
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Abstract

Intra cortical microstimulation (ICMS) in the primary visual cortex (V1) can generate the visual perception of phosphenes and evoke saccades directed to the stimulated location in the retinotopic map. Although ICMS is widely used, little is known about the evoked spatio-temporal patterns of neural activity and their relation to neural responses evoked by visual stimuli or saccade generation. To investigate this, we combined ICMS with Voltage Sensitive Dye Imaging in V1 of behaving monkeys and measured neural activity at high spatial (meso-scale) and temporal resolution. Small visual stimuli and ICMS evoked population activity spreading over few mm that propagated to extrastriate areas. The population responses evoked by ICMS showed faster dynamics and different spatial propagation patterns. Neural activity was higher in trials w/saccades compared with trials w/o saccades. In conclusion, our results uncover the spatio-temporal patterns evoked by ICMS and their relation to visual processing and saccade generation.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted May 04, 2020.
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Microstimulation in the primary visual cortex: activity patterns and their relation to visual responses and evoked saccades
R. Oz, H. Edelman-Klapper, S. Nivinsky-Margalit, H. Slovin
bioRxiv 2020.05.03.072322; doi: https://doi.org/10.1101/2020.05.03.072322
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Microstimulation in the primary visual cortex: activity patterns and their relation to visual responses and evoked saccades
R. Oz, H. Edelman-Klapper, S. Nivinsky-Margalit, H. Slovin
bioRxiv 2020.05.03.072322; doi: https://doi.org/10.1101/2020.05.03.072322

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