New Results
Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years
View ORCID ProfileSophia Frangou, Amirhossein Modabbernia, Gaelle E Doucet, View ORCID ProfileEfstathios Papachristou, Steven CR Williams, View ORCID ProfileIngrid Agartz, Moji Aghajani, View ORCID ProfileTheophilus N Akudjedu, Anton Albajes-Eizagirre, View ORCID ProfileDag Alnæs, Kathryn I Alpert, View ORCID ProfileMicael Andersson, View ORCID ProfileNancy Andreasen, View ORCID ProfileOle A Andreassen, View ORCID ProfilePhilip Asherson, View ORCID ProfileTobias Banaschewski, View ORCID ProfileNuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, View ORCID ProfileDorret I Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, View ORCID ProfileHenry Brodaty, View ORCID ProfileRachel M Brouwer, Jan K Buitelaar, View ORCID ProfileGeraldo F Busatto, Randy L Buckner, Vincent Calhoun, View ORCID ProfileErick J Canales-Rodríguez, Dara M Cannon, Xavier Caseras, Francisco X Castellanos, View ORCID ProfileSimon Cervenka, Tiffany M Chaim-Avancini, View ORCID ProfileChristopher RK Ching, View ORCID ProfileVincent P Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline AM Crone, Anders M Dale, Cristopher Davey, View ORCID ProfileEco JC de Geus, Lieuwe de Haan, View ORCID ProfileGreig I de Zubicaray, Anouk den Braber, Erin W Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S Dørum, View ORCID ProfileStefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, View ORCID ProfileSimon E Fisher, Jean-Paul Fouche, View ORCID ProfileBarbara Franke, View ORCID ProfileThomas Frodl, Paola Fuentes-Claramonte, View ORCID ProfileDavid C Glahn, Ian H Gotlib, Hans-Jörgen Grabe, Oliver Grimm, Nynke A Groenewold, Dominik Grotegerd, Oliver Gruber, View ORCID ProfilePatricia Gruner, Rachel E Gur, Ruben C Gur, View ORCID ProfileBen J Harrison, Catharine A Hartman, View ORCID ProfileSean N Hatton, Andreas Heinz, Dirk J Heslenfeld, Derrek P Hibar, Ian B Hickie, Beng-Choon Ho, View ORCID ProfilePieter J Hoekstra, Sarah Hohmann, View ORCID ProfileAvram J Holmes, View ORCID ProfileMartine Hoogman, Norbert Hosten, View ORCID ProfileFleur M Howells, View ORCID ProfileHilleke E Hulshoff Pol, View ORCID ProfileChaim Huyser, Neda Jahanshad, Anthony James, Jiyang Jiang, Erik G Jönsson, John A Joska, View ORCID ProfileRene Kahn, Andrew Kalnin, View ORCID ProfileRyota Kanai, Sim Kang, Marieke Klein, Tatyana P Klushnik, Laura Koenders, Sanne Koops, Bernd Krämer, View ORCID ProfileJonna Kuntsi, Jim Lagopoulos, Luisa Lázaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise WJ Machielsen, Sophie Maingault, Nicholas G Martin, Ignacio Martínez-Zalacaín, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C McDonald, Andrew M McIntosh, Katie L McMahon, View ORCID ProfileGenevieve McPhilemy, José M Menchón, View ORCID ProfileSarah E Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, View ORCID ProfileJan E Nordvik, Lars Nyberg, Jaap Oosterlaan, Víctor Ortiz-García de la Foz, View ORCID ProfileYannis Paloyelis, Paul Pauli, View ORCID ProfileGiulio Pergola, Edith Pomarol-Clotet, Maria J Portella, View ORCID ProfileSteven G Potkin, Joaquim Radua, Andreas Reif, Joshua L Roffman, Pedro GP Rosa, Matthew D Sacchet, View ORCID ProfilePerminder S Sachdev, Raymond Salvador, Pascual Sánchez-Juan, Salvador Sarró, Theodore D Satterthwaite, View ORCID ProfileAndrew J Saykin, Mauricio H Serpa, View ORCID ProfileLianne Schmaal, Knut Schnell, Gunter Schumann, View ORCID ProfileJordan W Smoller, Iris Sommer, Carles Soriano-Mas, Dan J Stein, Lachlan T Strike, Suzanne C Swagerman, View ORCID ProfileChristian K Tamnes, Henk S Temmingh, View ORCID ProfileSophia I Thomopoulos, View ORCID ProfileAlexander S Tomyshev, View ORCID ProfileDiana Tordesillas-Gutiérrez, Julian N Trollor, Jessica A Turner, View ORCID ProfileAnne Uhlmann, Odille A van den Heuvel, Dennis van den Meer, Nic JA van der Wee, Neeltje EM van Haren, Dennis van ’t Ent, Theo GM van Erp, Ilya M Veer, View ORCID ProfileDick J Veltman, Henry Völzke, Henrik Walter, Esther Walton, Lei Wang, View ORCID ProfileYang Wang, Thomas H Wassink, Bernd Weber, Wei Wen, John D West, View ORCID ProfileLars T Westlye, View ORCID ProfileHeather Whalley, Lara M Wierenga, Katharina Wittfeld, Daniel H Wolf, Margaret J Wright, Kun Yang, Yulyia Yoncheva, Marcus V Zanetti, Georg C Ziegler, Paul M Thompson, View ORCID ProfileDanai Dima
doi: https://doi.org/10.1101/2020.05.05.077834
Sophia Frangou
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, USA
2Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Canada
Amirhossein Modabbernia
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, USA
Gaelle E Doucet
3Boys Town National Research Hospital, University of Nebraska Medical Center, USA
Efstathios Papachristou
4Psychology and Human Development, Institute of Education, University College London, UK
Steven CR Williams
5Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UK
Ingrid Agartz
6Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Norway
7Department of Psychiatric Research, Diakonhjemmet Hospital, Norway
8Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden
Moji Aghajani
9Department of Psychiatry, Amsterdam University Medical Centre, Vrije Universiteit, Netherlands
Theophilus N Akudjedu
10Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Ireland
Anton Albajes-Eizagirre
11FIDMAG Germanes Hospitalàries, Spain
12Mental Health Research Networking Center (CIBERSAM), Spain
Dag Alnæs
6Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Norway
13Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Norway
Kathryn I Alpert
14Radiologics, INC, USA
Micael Andersson
15Umeå Center for Functional Brain Imaging, Umeå University, Sweden
16Department of Integrative Medical Biology, Umeå University, Sweden
Nancy Andreasen
17Department of Psychiatry, Carver College of Medicine, University of Iowa, USA
Ole A Andreassen
6Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Norway
7Department of Psychiatric Research, Diakonhjemmet Hospital, Norway
Philip Asherson
18Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Tobias Banaschewski
19Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Germany
Nuria Bargallo
20Imaging Diagnostic Centre, Barcelona University Clinic, Spain
Sarah Baumeister
19Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Germany
Ramona Baur-Streubel
21Department of Psychology, Biological Psychology, Clinical Psychology and Psychotherapy, University of Würzburg, Germany
Alessandro Bertolino
22Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Italy
Aurora Bonvino
22Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Italy
Dorret I Boomsma
23Department of Biological Psychology, Vrije Universiteit, Netherlands
Stefan Borgwardt
24Department of Psychiatry & Psychotherapy, University of Lübeck, Germany
Josiane Bourque
25Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
Daniel Brandeis
19Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Germany
Alan Breier
26Department of Radiology and Imaging Sciences, Indiana University School of Medicine, USA
Henry Brodaty
27Centre for Healthy Brain Ageing, University of New South Wales, Australia
Rachel M Brouwer
28Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Netherlands
Jan K Buitelaar
29Donders Center of Medical Neurosciences, Radboud University, Netherlands
30Donders Centre for Cognitive Neuroimaging, Radboud University, Netherlands
31Donders Institute for Brain, Cognition and Behaviour, Radboud University, Netherlands
Geraldo F Busatto
32Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil
Randy L Buckner
33Department of Psychology, Center for Brain Science, Harvard University, USA
34Department of Psychiatry, Massachusetts General Hospital, USA
Vincent Calhoun
35College of Arts and Sciences, Georgia State University, USA
36Computer Science, Math, Neuroscience and Physics at Georgia State University, USA
37Electrical and Computer Engineering and Biomedical Engineering, Georgia Institute of Technology, USA
38Neurology, Radiology, Psychiatry and Biomedical Engineering Emory University, USA
Erick J Canales-Rodríguez
11FIDMAG Germanes Hospitalàries, Spain
12Mental Health Research Networking Center (CIBERSAM), Spain
Dara M Cannon
10Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Ireland
Xavier Caseras
39MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK
Francisco X Castellanos
40Department of Child and Adolescent Psychiatry, New York University, USA
Simon Cervenka
8Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden
41Stockholm Health Care Services, Stockholm County Council, Karolinska University Hospital, Sweden
Tiffany M Chaim-Avancini
32Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil
Christopher RK Ching
42Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, USA
Vincent P Clark
43Department of Psychology, University of New Mexico, USA
44Mind Research Network, USA
Patricia Conrod
45Department of Psychiatry, Université de Montréal, Canada
Annette Conzelmann
46Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Tübingen, Germany
Benedicto Crespo-Facorro
12Mental Health Research Networking Center (CIBERSAM), Spain
47HU Virgen del Rocio, IBiS, University of Sevilla, Spain
Fabrice Crivello
48Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR5293, Université de Bordeaux, France
Eveline AM Crone
49Faculteit der Sociale Wetenschappen, Instituut Psychologie, Universiteit Leiden, Netherlands
Anders M Dale
50Center for Multimodal Imaging and Genetics, University of California San Diego, USA
51Department of Neurosciences, University of California San Diego USA
52Department of Radiology, University of California San Diego, USA
Cristopher Davey
53Centre for Youth Mental Health, University of Melbourne, Australia
54Orygen, Australia
Eco JC de Geus
23Department of Biological Psychology, Vrije Universiteit, Netherlands
Lieuwe de Haan
55Academisch Medisch Centrum, Universiteit van Amsterdam, Netherlands
Greig I de Zubicaray
56Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia
Anouk den Braber
23Department of Biological Psychology, Vrije Universiteit, Netherlands
Erin W Dickie
57Kimel Family Translational Imaging Genetics Research Laboratory, University of Toronto, Canada
58Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, University of Toronto, Canada
Annabella Di Giorgio
59Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Italy
Nhat Trung Doan
6Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Norway
Erlend S Dørum
6Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Norway
60Department of Psychology, University of Oslo, Norway
61Sunnaas Rehabilitation Hospital HT, Nesodden, Norway
Stefan Ehrlich
62Klinik und Poliklinik für Kinder und Jugendpsychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Germany
Susanne Erk
63Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Germany
Thomas Espeseth
60Department of Psychology, University of Oslo, Norway
Helena Fatouros-Bergman
8Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden
Simon E Fisher
64Language and Genetics Department, Max Planck Institute for Psycholinguistics, Netherlands
Jean-Paul Fouche
65Department of Psychiatry and Mental Health, University of Cape Town, South Africa
Barbara Franke
29Donders Center of Medical Neurosciences, Radboud University, Netherlands
31Donders Institute for Brain, Cognition and Behaviour, Radboud University, Netherlands
Thomas Frodl
66Department of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg, Germany
Paola Fuentes-Claramonte
11FIDMAG Germanes Hospitalàries, Spain
12Mental Health Research Networking Center (CIBERSAM), Spain
David C Glahn
67Department of Psychiatry, Tommy Fuss Center for Neuropsychiatric Disease Research Boston Children’s Hospital, Harvard Medical School, USA
Ian H Gotlib
68Department of Psychology, Stanford University, USA
Hans-Jörgen Grabe
69Department of Psychiatry and Psychotherapy, University Medicine Greifswald, University of Greifswald, Germany
Oliver Grimm
70Department for Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Frankfurt, Goethe Universitat, Germany
Nynke A Groenewold
65Department of Psychiatry and Mental Health, University of Cape Town, South Africa
71Neuroscience Institute, University of Cape Town, South Africa
Dominik Grotegerd
72Department of Psychiatry and Psychotherapy, University of Muenster, Germany
Oliver Gruber
73Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany
Patricia Gruner
74Department of Psychiatry, Yale University, USA
75Learning Based Recovery Center, VA Connecticut Health System, USA
Rachel E Gur
25Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
76Lifespan Brain Institute, Perelman School of Medicine, University of Pennsylvania, USA
77Children’s Hospital of Philadelphia, University of Pennsylvania, USA
Ruben C Gur
25Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
76Lifespan Brain Institute, Perelman School of Medicine, University of Pennsylvania, USA
77Children’s Hospital of Philadelphia, University of Pennsylvania, USA
Ben J Harrison
78Melbourne Neuropsychiatry Center, University of Melbourne, Australia
Catharine A Hartman
79Interdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Netherlands
Sean N Hatton
51Department of Neurosciences, University of California San Diego USA
80Brain and Mind Centre, University of Sydney, Australia
Andreas Heinz
63Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Germany
Dirk J Heslenfeld
81Departments of Experimental and Clinical Psychology, Vrije Universiteit Amsterdam, Netherlands
Derrek P Hibar
82Personalized Healthcare, Genentech, Inc., USA
Ian B Hickie
80Brain and Mind Centre, University of Sydney, Australia
Beng-Choon Ho
17Department of Psychiatry, Carver College of Medicine, University of Iowa, USA
Pieter J Hoekstra
83Department of Psychiatry, University Medical Center Groningen, University of Groningen, Netherlands
Sarah Hohmann
19Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Germany
Avram J Holmes
84Department of Psychology, Yale University, USA
Martine Hoogman
31Donders Institute for Brain, Cognition and Behaviour, Radboud University, Netherlands
85Radboud University Medical Center, The Netherlands
Norbert Hosten
86Norbert Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, University of Greifswald, Germany
Fleur M Howells
65Department of Psychiatry and Mental Health, University of Cape Town, South Africa
71Neuroscience Institute, University of Cape Town, South Africa
Hilleke E Hulshoff Pol
28Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Netherlands
Chaim Huyser
87Bascule, Academic Centre for Children and Adolescent Psychiatry, Netherlands
Neda Jahanshad
42Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, USA
Anthony James
88Department of Psychiatry, Oxford University, UK
Jiyang Jiang
27Centre for Healthy Brain Ageing, University of New South Wales, Australia
Erik G Jönsson
6Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Norway
8Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden
John A Joska
65Department of Psychiatry and Mental Health, University of Cape Town, South Africa
Rene Kahn
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, USA
Andrew Kalnin
89Depart of Radiology, The Ohio State University College of Medicine, USA
Ryota Kanai
90Department of Neuroinformatics, Araya, Inc., Japan
Sim Kang
91Institute of Mental Health, Singapore
Marieke Klein
31Donders Institute for Brain, Cognition and Behaviour, Radboud University, Netherlands
85Radboud University Medical Center, The Netherlands
Tatyana P Klushnik
92Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Russian Academy of Medical Sciences, Russia
Laura Koenders
55Academisch Medisch Centrum, Universiteit van Amsterdam, Netherlands
Sanne Koops
28Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Netherlands
Bernd Krämer
73Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany
Jonna Kuntsi
18Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Jim Lagopoulos
93Sunshine Coast Mind and Neuroscience, Thompson Institute, University of the Sunshine Coast, Australia
Luisa Lázaro
94Department of Child and Adolescent Psychiatry and Psychology, Barcelona University Clinic, Spain
95August Pi i Sunyer Biomedical Research Institut (IDIBAPS), Spain
Irina Lebedeva
96Mental Health Research Center, Moscow, Russia
Won Hee Lee
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, USA
Klaus-Peter Lesch
97Department of Psychiatry, Psychosomatics and Psychotherapy, Julius-Maximilians Universität Würzburg, Germany
Christine Lochner
98SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, South Africa
Marise WJ Machielsen
55Academisch Medisch Centrum, Universiteit van Amsterdam, Netherlands
Sophie Maingault
48Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR5293, Université de Bordeaux, France
Nicholas G Martin
99Queensland Institute of Medical Research, Berghofer Medical Research Institute, Australia
Ignacio Martínez-Zalacaín
12Mental Health Research Networking Center (CIBERSAM), Spain
100Department of Psychiatry, Bellvitge University Hospital-IDIBELL, University of Barcelona, Spain
David Mataix-Cols
8Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden
41Stockholm Health Care Services, Stockholm County Council, Karolinska University Hospital, Sweden
Bernard Mazoyer
48Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR5293, Université de Bordeaux, France
Colm McDonald
10Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Ireland
Brenna C McDonald
26Department of Radiology and Imaging Sciences, Indiana University School of Medicine, USA
Andrew M McIntosh
101Division of Psychiatry, University of Edinburgh, UK
Katie L McMahon
102Herston Imaging Research Facility, Queensland University of Technology, Australia
Genevieve McPhilemy
10Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Ireland
José M Menchón
12Mental Health Research Networking Center (CIBERSAM), Spain
100Department of Psychiatry, Bellvitge University Hospital-IDIBELL, University of Barcelona, Spain
Sarah E Medland
99Queensland Institute of Medical Research, Berghofer Medical Research Institute, Australia
Andreas Meyer-Lindenberg
103Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Germany
Jilly Naaijen
30Donders Centre for Cognitive Neuroimaging, Radboud University, Netherlands
31Donders Institute for Brain, Cognition and Behaviour, Radboud University, Netherlands
85Radboud University Medical Center, The Netherlands
Pablo Najt
10Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Ireland
Tomohiro Nakao
104Department of Clinical Medicine, Kyushu University, Japan
Jan E Nordvik
105CatoSenteret Rehabilitation Hospital, Norway
Lars Nyberg
15Umeå Center for Functional Brain Imaging, Umeå University, Sweden
Jaap Oosterlaan
106Department of Clinical Neuropsychology, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, Netherlands
Víctor Ortiz-García de la Foz
12Mental Health Research Networking Center (CIBERSAM), Spain
107Department of Psychiatry, University Hospital “Marques de Valdecilla”, Instituto de Investigación Valdecilla (IDIVAL), Spain
108Instituto de Salud Carlos III, Spain
Yannis Paloyelis
5Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UK
Paul Pauli
21Department of Psychology, Biological Psychology, Clinical Psychology and Psychotherapy, University of Würzburg, Germany
109Centre of Mental Health, University of Würzburg, Germany
Giulio Pergola
22Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Italy
Edith Pomarol-Clotet
11FIDMAG Germanes Hospitalàries, Spain
12Mental Health Research Networking Center (CIBERSAM), Spain
Maria J Portella
12Mental Health Research Networking Center (CIBERSAM), Spain
110Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Institut d’Investigació Biomèdica Sant Pau, Universitat Autònoma de Barcelona, Spain
Steven G Potkin
111Department of Psychiatry, University of California at Irvine, USA
Joaquim Radua
8Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden
95August Pi i Sunyer Biomedical Research Institut (IDIBAPS), Spain
112Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
Andreas Reif
70Department for Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Frankfurt, Goethe Universitat, Germany
Joshua L Roffman
113Department of Psychiatry, Massachusetts General Hospital, USA
Pedro GP Rosa
32Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil
Matthew D Sacchet
114Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, USA
Perminder S Sachdev
27Centre for Healthy Brain Ageing, University of New South Wales, Australia
Raymond Salvador
11FIDMAG Germanes Hospitalàries, Spain
12Mental Health Research Networking Center (CIBERSAM), Spain
Pascual Sánchez-Juan
107Department of Psychiatry, University Hospital “Marques de Valdecilla”, Instituto de Investigación Valdecilla (IDIVAL), Spain
115Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Spain
Salvador Sarró
11FIDMAG Germanes Hospitalàries, Spain
12Mental Health Research Networking Center (CIBERSAM), Spain
Theodore D Satterthwaite
25Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
Andrew J Saykin
26Department of Radiology and Imaging Sciences, Indiana University School of Medicine, USA
Mauricio H Serpa
32Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil
Lianne Schmaal
53Centre for Youth Mental Health, University of Melbourne, Australia
54Orygen, Australia
Knut Schnell
116Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany
Gunter Schumann
18Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
117Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
Jordan W Smoller
118Center for Genomic Medicine, Massachusetts General Hospital, USA
Iris Sommer
119Department of Biomedical Sciences of Cells and Systems, Rijksuniversiteit Groningen, University Medical Center Groningen, Netherlands
Carles Soriano-Mas
12Mental Health Research Networking Center (CIBERSAM), Spain
100Department of Psychiatry, Bellvitge University Hospital-IDIBELL, University of Barcelona, Spain
Dan J Stein
98SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, South Africa
Lachlan T Strike
120Queensland Brain Institute, University of Queensland, Australia
Suzanne C Swagerman
23Department of Biological Psychology, Vrije Universiteit, Netherlands
Christian K Tamnes
121PROMENTA Research Center, Department of Psychology, University of Oslo, Norway
Henk S Temmingh
65Department of Psychiatry and Mental Health, University of Cape Town, South Africa
Sophia I Thomopoulos
42Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, USA
Alexander S Tomyshev
92Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Russian Academy of Medical Sciences, Russia
Diana Tordesillas-Gutiérrez
12Mental Health Research Networking Center (CIBERSAM), Spain
122Neuroimaging Unit, Technological Facilities, Valdecilla Biomedical Research Institute IDIVAL, Spain
Julian N Trollor
27Centre for Healthy Brain Ageing, University of New South Wales, Australia
Jessica A Turner
35College of Arts and Sciences, Georgia State University, USA
Anne Uhlmann
65Department of Psychiatry and Mental Health, University of Cape Town, South Africa
Odille A van den Heuvel
9Department of Psychiatry, Amsterdam University Medical Centre, Vrije Universiteit, Netherlands
Dennis van den Meer
6Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Norway
13Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Norway
123School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Netherlands
Nic JA van der Wee
124Department of Psychiatry, Leiden University Medical Center, Netherlands
125Leiden Institute for Brain and Cognition, Netherlands
Neeltje EM van Haren
126Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children’s Hospital, Rotterdam, The Netherlands
Dennis van ’t Ent
23Department of Biological Psychology, Vrije Universiteit, Netherlands
Theo GM van Erp
111Department of Psychiatry, University of California at Irvine, USA
127Center for the Neurobiology of Learning and Memory, University of California Irvine, USA
Ilya M Veer
63Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Germany
Dick J Veltman
9Department of Psychiatry, Amsterdam University Medical Centre, Vrije Universiteit, Netherlands
Henry Völzke
128Institute of Community Medicine, University Medicine, Greifswald, University of Greifswald, Germany
Henrik Walter
63Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Germany
Esther Walton
129MRC Integrative Epidemiology Unit, Population Health Sciences Bristol Medical School, Bristol University, UK
Lei Wang
130Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, USA
Yang Wang
131Department of Radiology, Medical College of Wisconsin, USA
Thomas H Wassink
17Department of Psychiatry, Carver College of Medicine, University of Iowa, USA
Bernd Weber
132Institute for Experimental Epileptology and Cognition Research, University of Bonn, Germany
Wei Wen
27Centre for Healthy Brain Ageing, University of New South Wales, Australia
John D West
26Department of Radiology and Imaging Sciences, Indiana University School of Medicine, USA
Lars T Westlye
60Department of Psychology, University of Oslo, Norway
Heather Whalley
101Division of Psychiatry, University of Edinburgh, UK
Lara M Wierenga
133Developmental and Educational Psychology Unit, Institute of Psychology, Leiden University, Netherlands
Katharina Wittfeld
134German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald Site, University of Greifswald, Germany
Daniel H Wolf
25Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
Margaret J Wright
120Queensland Brain Institute, University of Queensland, Australia
Kun Yang
135National High Magnetic Field Laboratory, Florida State University, USA
Yulyia Yoncheva
40Department of Child and Adolescent Psychiatry, New York University, USA
Marcus V Zanetti
32Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil
Georg C Ziegler
136Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Germany
Paul M Thompson
42Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, USA
Danai Dima
5Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UK
137Department of Psychology, School of Arts and Social Sciences, City, University of London, UK
Abstract
Delineating age-related cortical trajectories in healthy individuals is critical given the association of cortical thickness with cognition and behaviour. Previous research has shown that deriving robust estimates of age-related brain morphometric changes requires large-scale studies. In response, we conducted a large-scale analysis of cortical thickness in 17,075 individuals aged 3-90 years by pooling data through the Lifespan Working group of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium. We used fractional polynomial (FP) regression to characterize age-related trajectories in cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma (LMS) method. Inter-individual variability was estimated using meta-analysis and one-way analysis of variance. Overall, cortical thickness peaked in childhood and had a steep decrease during the first 2-3 decades of life; thereafter, it showed a gradual monotonic decrease which was steeper in men than in women particularly in middle-life. Notable exceptions to this general pattern were entorhinal, temporopolar and anterior cingulate cortices. Inter-individual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results reconcile uncertainties about age-related trajectories of cortical thickness; the centile values provide estimates of normative variance in cortical thickness, and may assist in detecting abnormal deviations in cortical thickness, and associated behavioural, cognitive and clinical outcomes.
Competing Interest Statement
The authors have declared no competing interest.
Abbreviations of studies
- ADHD-NF
- Attention Deficit Hyperactivity Disorder-Neurofeedback Study;
- AMC
- Amsterdam Medisch Centrum;
- Basel
- University of Basel;
- Barcelona
- University of Barcelona;
- Betula
- Swedish longitudinal study on aging, memory, and dementia;
- BIG
- Brain Imaging Genetics;
- BIL&GIN
- a multimodal multidimensional database for investigating hemispheric specialization;
- Bonn
- University of Bonn;
- BrainSCALE
- Brain Structure and Cognition: an Adolescence Longitudinal twin study;
- CAMH
- Centre for Addiction and Mental Health;
- Cardiff
- Cardiff University;
- CEG
- Cognitive-experimental and Genetic study of ADHD and Control Sibling Pairs;
- CIAM
- Cortical Inhibition and Attentional Modulation study;
- CLiNG
- Clinical Neuroscience Göttingen;
- CODE
- formerly Cognitive Behavioral Analysis System of Psychotherapy (CBASP) study;
- Edinburgh
- The University of Edinburgh;
- ENIGMA-HIV
- Enhancing NeuroImaging Genetics through Meta-Analysis-Human Immunodeficiency Virus Working Group;
- ENIGMA-OCD
- Enhancing NeuroImaging Genetics through Meta-Analysis-Obsessive Compulsive Disorder Working Group;
- FBIRN
- Function Biomedical Informatics Research Network;
- FIDMAG
- Fundación para la Investigación y Docencia Maria Angustias Giménez;
- GSP
- Brain Genomics Superstruct Project;
- HMS
- Homburg Multidiagnosis Study;
- HUBIN
- Human Brain Informatics;
- IDIVAL
- Valdecilla Biomedical Research Institute;
- IMAGEN
- the IMAGEN Consortium;
- IMH
- Institute of Mental Health, Singapore;
- IMpACT
- The International Multicentre persistent ADHD Genetics Collaboration;
- Indiana
- Indiana University School of Medicine;
- Johns Hopkins
- Johns Hopkins University;
- KaSP
- The Karolinska Schizophrenia Project;
- Leiden
- Leiden University;
- MAS
- Memory and Ageing Study;
- MCIC
- MIND Clinical Imaging Consortium formed by the Mental Illness and Neuroscience Discovery (MIND) Institute now the Mind Research Network;
- Melbourne
- University of Melbourne;
- Meth-CT
- study of methamphetamine users, University of Cape Town;
- MHRC
- Mental Health Research Center;
- Muenster
- Muenster University;
- NESDA
- The Netherlands Study of Depression and Anxiety;
- NeuroIMAGE
- Dutch part of the International Multicenter ADHD Genetics (IMAGE) study; Neuroventure: the imaging part of the Co-Venture Trial funded by the Canadian Institutes of Health Research (CIHR);
- NCNG
- Norwegian Cognitive NeuroGenetics sample;
- NTR
- Netherlands Twin Register;
- NU
- Northwestern University;
- NUIG
- National University of Ireland Galway;
- NYU
- New York University;
- OATS
- Older Australian Twins Study;
- Olin
- Olin Neuropsychiatric Research Center;
- Oxford
- Oxford University;
- QTIM
- Queensland Twin Imaging;
- Sao Paulo
- University of Sao Paulo;
- SCORE
- University of Basel Study;
- SHIP-2 and SHIP TREND
- Study of Health in Pomerania;
- Staged-Dep
- Stages of Depression Study;
- Stanford
- Stanford University;
- StrokeMRI
- Stroke Magnetic Resonance Imaging;
- Sydney
- University of Sydney;
- TOP
- Tematisk Område Psykoser (Thematically Organized Psychosis Research);
- TS-EUROTRAIN
- European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome;
- Tuebingen
- University of Tuebingen;
- UMCU
- Universitair Medisch Centrum Utrecht;
- UNIBA
- University of Bari Aldo Moro;
- UPENN
- University of Pennsylvania;
- Yale
- Yale University
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted May 07, 2020.
Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years
Sophia Frangou, Amirhossein Modabbernia, Gaelle E Doucet, Efstathios Papachristou, Steven CR Williams, Ingrid Agartz, Moji Aghajani, Theophilus N Akudjedu, Anton Albajes-Eizagirre, Dag Alnæs, Kathryn I Alpert, Micael Andersson, Nancy Andreasen, Ole A Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret I Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M Brouwer, Jan K Buitelaar, Geraldo F Busatto, Randy L Buckner, Vincent Calhoun, Erick J Canales-Rodríguez, Dara M Cannon, Xavier Caseras, Francisco X Castellanos, Simon Cervenka, Tiffany M Chaim-Avancini, Christopher RK Ching, Vincent P Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline AM Crone, Anders M Dale, Cristopher Davey, Eco JC de Geus, Lieuwe de Haan, Greig I de Zubicaray, Anouk den Braber, Erin W Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S Dørum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C Glahn, Ian H Gotlib, Hans-Jörgen Grabe, Oliver Grimm, Nynke A Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E Gur, Ruben C Gur, Ben J Harrison, Catharine A Hartman, Sean N Hatton, Andreas Heinz, Dirk J Heslenfeld, Derrek P Hibar, Ian B Hickie, Beng-Choon Ho, Pieter J Hoekstra, Sarah Hohmann, Avram J Holmes, Martine Hoogman, Norbert Hosten, Fleur M Howells, Hilleke E Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Jiyang Jiang, Erik G Jönsson, John A Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Sim Kang, Marieke Klein, Tatyana P Klushnik, Laura Koenders, Sanne Koops, Bernd Krämer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lázaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise WJ Machielsen, Sophie Maingault, Nicholas G Martin, Ignacio Martínez-Zalacaín, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C McDonald, Andrew M McIntosh, Katie L McMahon, Genevieve McPhilemy, José M Menchón, Sarah E Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E Nordvik, Lars Nyberg, Jaap Oosterlaan, Víctor Ortiz-García de la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J Portella, Steven G Potkin, Joaquim Radua, Andreas Reif, Joshua L Roffman, Pedro GP Rosa, Matthew D Sacchet, Perminder S Sachdev, Raymond Salvador, Pascual Sánchez-Juan, Salvador Sarró, Theodore D Satterthwaite, Andrew J Saykin, Mauricio H Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Jordan W Smoller, Iris Sommer, Carles Soriano-Mas, Dan J Stein, Lachlan T Strike, Suzanne C Swagerman, Christian K Tamnes, Henk S Temmingh, Sophia I Thomopoulos, Alexander S Tomyshev, Diana Tordesillas-Gutiérrez, Julian N Trollor, Jessica A Turner, Anne Uhlmann, Odille A van den Heuvel, Dennis van den Meer, Nic JA van der Wee, Neeltje EM van Haren, Dennis van ’t Ent, Theo GM van Erp, Ilya M Veer, Dick J Veltman, Henry Völzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H Wassink, Bernd Weber, Wei Wen, John D West, Lars T Westlye, Heather Whalley, Lara M Wierenga, Katharina Wittfeld, Daniel H Wolf, Margaret J Wright, Kun Yang, Yulyia Yoncheva, Marcus V Zanetti, Georg C Ziegler, Paul M Thompson, Danai Dima
bioRxiv 2020.05.05.077834; doi: https://doi.org/10.1101/2020.05.05.077834
Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years
Sophia Frangou, Amirhossein Modabbernia, Gaelle E Doucet, Efstathios Papachristou, Steven CR Williams, Ingrid Agartz, Moji Aghajani, Theophilus N Akudjedu, Anton Albajes-Eizagirre, Dag Alnæs, Kathryn I Alpert, Micael Andersson, Nancy Andreasen, Ole A Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret I Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M Brouwer, Jan K Buitelaar, Geraldo F Busatto, Randy L Buckner, Vincent Calhoun, Erick J Canales-Rodríguez, Dara M Cannon, Xavier Caseras, Francisco X Castellanos, Simon Cervenka, Tiffany M Chaim-Avancini, Christopher RK Ching, Vincent P Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline AM Crone, Anders M Dale, Cristopher Davey, Eco JC de Geus, Lieuwe de Haan, Greig I de Zubicaray, Anouk den Braber, Erin W Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S Dørum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C Glahn, Ian H Gotlib, Hans-Jörgen Grabe, Oliver Grimm, Nynke A Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E Gur, Ruben C Gur, Ben J Harrison, Catharine A Hartman, Sean N Hatton, Andreas Heinz, Dirk J Heslenfeld, Derrek P Hibar, Ian B Hickie, Beng-Choon Ho, Pieter J Hoekstra, Sarah Hohmann, Avram J Holmes, Martine Hoogman, Norbert Hosten, Fleur M Howells, Hilleke E Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Jiyang Jiang, Erik G Jönsson, John A Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Sim Kang, Marieke Klein, Tatyana P Klushnik, Laura Koenders, Sanne Koops, Bernd Krämer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lázaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise WJ Machielsen, Sophie Maingault, Nicholas G Martin, Ignacio Martínez-Zalacaín, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C McDonald, Andrew M McIntosh, Katie L McMahon, Genevieve McPhilemy, José M Menchón, Sarah E Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E Nordvik, Lars Nyberg, Jaap Oosterlaan, Víctor Ortiz-García de la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J Portella, Steven G Potkin, Joaquim Radua, Andreas Reif, Joshua L Roffman, Pedro GP Rosa, Matthew D Sacchet, Perminder S Sachdev, Raymond Salvador, Pascual Sánchez-Juan, Salvador Sarró, Theodore D Satterthwaite, Andrew J Saykin, Mauricio H Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Jordan W Smoller, Iris Sommer, Carles Soriano-Mas, Dan J Stein, Lachlan T Strike, Suzanne C Swagerman, Christian K Tamnes, Henk S Temmingh, Sophia I Thomopoulos, Alexander S Tomyshev, Diana Tordesillas-Gutiérrez, Julian N Trollor, Jessica A Turner, Anne Uhlmann, Odille A van den Heuvel, Dennis van den Meer, Nic JA van der Wee, Neeltje EM van Haren, Dennis van ’t Ent, Theo GM van Erp, Ilya M Veer, Dick J Veltman, Henry Völzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H Wassink, Bernd Weber, Wei Wen, John D West, Lars T Westlye, Heather Whalley, Lara M Wierenga, Katharina Wittfeld, Daniel H Wolf, Margaret J Wright, Kun Yang, Yulyia Yoncheva, Marcus V Zanetti, Georg C Ziegler, Paul M Thompson, Danai Dima
bioRxiv 2020.05.05.077834; doi: https://doi.org/10.1101/2020.05.05.077834
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