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Validity of the Lumen® hand-held metabolic device to measure fuel utilization in healthy young adults

View ORCID ProfileKent A. Lorenz, View ORCID ProfileShlomo Yeshurun, Richard Aziz, Julissa Ortiz-Delatorre, View ORCID ProfileJames R. Bagley, Merav Mor, Marialice Kern
doi: https://doi.org/10.1101/2020.05.05.078980
Kent A. Lorenz
1Exercise Physiology Laboratory, San Francisco State University, Department of Kinesiology, San Francisco, CA USA
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  • ORCID record for Kent A. Lorenz
  • For correspondence: kalorenz@sfsu.edu merav@lumen.me
Shlomo Yeshurun
2Metaflow Ltd., Tel Aviv, Israel
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Richard Aziz
1Exercise Physiology Laboratory, San Francisco State University, Department of Kinesiology, San Francisco, CA USA
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Julissa Ortiz-Delatorre
1Exercise Physiology Laboratory, San Francisco State University, Department of Kinesiology, San Francisco, CA USA
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James R. Bagley
1Exercise Physiology Laboratory, San Francisco State University, Department of Kinesiology, San Francisco, CA USA
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Merav Mor
2Metaflow Ltd., Tel Aviv, Israel
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  • For correspondence: kalorenz@sfsu.edu merav@lumen.me
Marialice Kern
1Exercise Physiology Laboratory, San Francisco State University, Department of Kinesiology, San Francisco, CA USA
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Abstract

Objective To evaluate the validity of a novel hand-held device (Lumen®) for measuring metabolic fuel utilization in healthy young adults.

Background Metabolic carts measure the carbon dioxide produced and oxygen consumed from the breath in order to assess metabolic fuel usage (carbohydrates vs. fats). However, these systems are expensive, time-consuming, and only available in the clinic. A small hand-held device capable of measuring metabolic fuel via CO2 was developed.

Approach Metabolic fuel usage was assessed in healthy participants (n = 33; age: 23.1 ± 3.9 y) via respiratory exchange ratio (RER) values from the “gold-standard” metabolic cart as well as %CO2 from the Lumen device. Measurements were performed at rest in two conditions, fasting, and after consuming 150 grams of glucose in order to determine changes in metabolic fuel. Major axis regression was performed as well as Bland-Altman plots and linear regressions to test for agreement between RER and Lumen %CO2.

Main results Both RER and Lumen %CO2 significantly increased after glucose intake compared with fasting conditions (p < 0.0001). Regression analyses and Bland-Altman plots revealed an agreement between the two measurements (mean bias = 3.505; limits of agreement = 2.784 - 4.226) with a fixed bias resulting from the nature of the different units.

Significance This study shows the validity of Lumen® to estimate metabolic fuel utilization in a comparable manner with the “gold-standard” metabolic cart, conveniently providing real-time metabolic information for users anywhere.

Competing Interest Statement

SY and MM are employees of Metaflow Ltd., and contributed to the design and analysis of the study as well as the preparation of the manuscript. The other authors declare that they have no competing interests.

  • Abbreviations

    RQ
    Respiratory Quotient
    RER
    Respiratory Exchange Ratio
    MF
    Metabolic Flexibility
  • Copyright 
    The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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    Posted May 07, 2020.
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    Validity of the Lumen® hand-held metabolic device to measure fuel utilization in healthy young adults
    Kent A. Lorenz, Shlomo Yeshurun, Richard Aziz, Julissa Ortiz-Delatorre, James R. Bagley, Merav Mor, Marialice Kern
    bioRxiv 2020.05.05.078980; doi: https://doi.org/10.1101/2020.05.05.078980
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    Validity of the Lumen® hand-held metabolic device to measure fuel utilization in healthy young adults
    Kent A. Lorenz, Shlomo Yeshurun, Richard Aziz, Julissa Ortiz-Delatorre, James R. Bagley, Merav Mor, Marialice Kern
    bioRxiv 2020.05.05.078980; doi: https://doi.org/10.1101/2020.05.05.078980

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