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Validity of the Lumen® hand-held metabolic device to measure fuel utilization in healthy young adults

View ORCID ProfileKent A. Lorenz, View ORCID ProfileShlomo Yeshurun, Richard Aziz, Julissa Ortiz-Delatorre, View ORCID ProfileJames R. Bagley, Merav Mor, Marialice Kern
doi: https://doi.org/10.1101/2020.05.05.078980
Kent A. Lorenz
1Exercise Physiology Laboratory, San Francisco State University, Department of Kinesiology, San Francisco, CA USA
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  • ORCID record for Kent A. Lorenz
  • For correspondence: kalorenz@sfsu.edu merav@lumen.me
Shlomo Yeshurun
2Metaflow Ltd., Tel Aviv, Israel
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Richard Aziz
1Exercise Physiology Laboratory, San Francisco State University, Department of Kinesiology, San Francisco, CA USA
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Julissa Ortiz-Delatorre
1Exercise Physiology Laboratory, San Francisco State University, Department of Kinesiology, San Francisco, CA USA
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James R. Bagley
1Exercise Physiology Laboratory, San Francisco State University, Department of Kinesiology, San Francisco, CA USA
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Merav Mor
2Metaflow Ltd., Tel Aviv, Israel
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  • For correspondence: kalorenz@sfsu.edu merav@lumen.me
Marialice Kern
1Exercise Physiology Laboratory, San Francisco State University, Department of Kinesiology, San Francisco, CA USA
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Abstract

Background Metabolic carts measure the carbon dioxide produced and oxygen consumed from the breath in order to assess metabolic fuel usage (carbohydrates vs. fats). However, these systems are expensive, time-consuming, and only available in the clinic. A small hand-held device capable of measuring metabolic fuel via CO2 from exhaled air has been developed

Objective To evaluate the validity of a novel hand-held device (Lumen®) for measuring metabolic fuel utilization in healthy young adults

Methods Metabolic fuel usage was assessed in healthy participants (n = 33; age: 23.1 ± 3.9 y) via respiratory exchange ratio (RER) values from the “gold-standard” metabolic cart as well as %CO2 from the Lumen device. Measurements were performed at rest in two conditions, fasting, and after consuming 150 grams of glucose in order to determine changes in metabolic fuel. Reduced major axis regression was performed as well as Bland-Altman plots and linear regressions to test for agreement between RER and Lumen %CO2.

Results Both RER and Lumen %CO2 significantly increased after glucose intake compared with fasting conditions (P < .0001). Regression analyses and Bland-Altman plots revealed an agreement between the two measurements with a systematic bias resulting from the nature of the different units.

Conclusions This study shows the validity of Lumen® to estimate metabolic fuel utilization in a comparable manner with the “gold-standard” metabolic cart, providing the ability for real-time metabolic information for users under any circumstances.

Competing Interest Statement

SY and MM are employees of Metaflow Ltd., and contributed to the design and analysis of the study as well as the preparation of the manuscript. The other authors declare no conflicts of interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted October 28, 2020.
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Validity of the Lumen® hand-held metabolic device to measure fuel utilization in healthy young adults
Kent A. Lorenz, Shlomo Yeshurun, Richard Aziz, Julissa Ortiz-Delatorre, James R. Bagley, Merav Mor, Marialice Kern
bioRxiv 2020.05.05.078980; doi: https://doi.org/10.1101/2020.05.05.078980
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Validity of the Lumen® hand-held metabolic device to measure fuel utilization in healthy young adults
Kent A. Lorenz, Shlomo Yeshurun, Richard Aziz, Julissa Ortiz-Delatorre, James R. Bagley, Merav Mor, Marialice Kern
bioRxiv 2020.05.05.078980; doi: https://doi.org/10.1101/2020.05.05.078980

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