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Immunodietica: interrogating the role of diet in autoimmune disease

View ORCID ProfileIosif M. Gershteyn, View ORCID ProfileAndrey A. Burov, View ORCID ProfileBrenda Y. Miao, View ORCID ProfileVasco H. Morais, View ORCID ProfileLeonardo M. R. Ferreira
doi: https://doi.org/10.1101/2020.05.05.079418
Iosif M. Gershteyn
1Ajax Biomedical Foundation, Newton, MA, USA
2ImmuVia LLC, Waltham, MA, USA
3SoundMedicine LLC, Waltham, MA, USA
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  • ORCID record for Iosif M. Gershteyn
  • For correspondence: iosifmg@bu.edu leonardo.ferreira@ucsf.edu
Andrey A. Burov
1Ajax Biomedical Foundation, Newton, MA, USA
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Brenda Y. Miao
4Diabetes Center, University of California, San Francisco, San Francisco, CA, USA
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Vasco H. Morais
5Department of Surgery, University of California, San Francisco, San Francisco, CA, USA
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Leonardo M. R. Ferreira
1Ajax Biomedical Foundation, Newton, MA, USA
4Diabetes Center, University of California, San Francisco, San Francisco, CA, USA
5Department of Surgery, University of California, San Francisco, San Francisco, CA, USA
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  • For correspondence: iosifmg@bu.edu leonardo.ferreira@ucsf.edu
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Abstract

Diet is an environmental factor in autoimmune disorders, where the immune system erroneously destroys one’s own tissues. Yet, interactions between diet and autoimmunity remain largely unexplored, particularly the impact of immunogenetics, one’s human leukocyte antigen (HLA) allele make-up, in this interplay. Here, we interrogated animals and plants for the presence of epitopes implicated in human autoimmune diseases. We mapped autoimmune epitope distribution across organisms and determined their tissue expression pattern. Interestingly, diet-derived epitopes implicated in a disease were more likely to bind to HLA alleles associated with that disease than to protective alleles, with visible differences between organisms with similar autoimmune epitope content. We then analyzed an individual’s HLA haplotype, generating a personalized heatmap of potential dietary autoimmune triggers. Our work uncovered differences in autoimmunogenic potential across food sources and revealed differential binding of diet-derived epitopes to autoimmune disease-associated HLA alleles, shedding light on the impact of diet on autoimmunity.

Competing Interest Statement

I.M.G. and L.M.R.F. received funding from Ajax Biomedical Foundation, a 501(c)(3) corporation.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 07, 2020.
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Immunodietica: interrogating the role of diet in autoimmune disease
Iosif M. Gershteyn, Andrey A. Burov, Brenda Y. Miao, Vasco H. Morais, Leonardo M. R. Ferreira
bioRxiv 2020.05.05.079418; doi: https://doi.org/10.1101/2020.05.05.079418
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Immunodietica: interrogating the role of diet in autoimmune disease
Iosif M. Gershteyn, Andrey A. Burov, Brenda Y. Miao, Vasco H. Morais, Leonardo M. R. Ferreira
bioRxiv 2020.05.05.079418; doi: https://doi.org/10.1101/2020.05.05.079418

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