Identification of 370 loci for age at onset of sexual and reproductive behaviour, highlighting common aetiology with reproductive biology, externalizing behaviour and longevity

Melinda C. Mills; Felix C. Tropf; David M. Brazel; Natalie van Zuydam; Ahmad Vaez; eQTLGen Consortium; BIOS Consortium; Tune H. Pers; Harold Snieder; John R.B. Perry; Ken K. Ong; Marcel den Hoed; Nicola Barban; Felix R. Day; on behalf of the Human Reproductive Behaviour Consortium

doi:10.1101/2020.05.06.081273

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Identification of 370 loci for age at onset of sexual and reproductive behaviour, highlighting common aetiology with reproductive biology, externalizing behaviour and longevity

View ORCID ProfileMelinda C. Mills, View ORCID ProfileFelix C. Tropf, View ORCID ProfileDavid M. Brazel, View ORCID ProfileNatalie van Zuydam, View ORCID ProfileAhmad Vaez, eQTLGen Consortium, BIOS Consortium, View ORCID ProfileTune H. Pers, View ORCID ProfileHarold Snieder, View ORCID ProfileJohn R.B. Perry, View ORCID ProfileKen K. Ong, View ORCID ProfileMarcel den Hoed, View ORCID ProfileNicola Barban, View ORCID ProfileFelix R. Day, on behalf of the Human Reproductive Behaviour Consortium

doi: https://doi.org/10.1101/2020.05.06.081273

Melinda C. Mills

1Leverhulme Centre for Demographic Science, University of Oxford, Oxford, United Kingdom

2Nuffield College, University of Oxford, Oxford, United Kingdom

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For correspondence: melinda.mills@nuffield.ox.ac.uk felix.day@mrc-epid.cam.ac.uk

Felix C. Tropf

1Leverhulme Centre for Demographic Science, University of Oxford, Oxford, United Kingdom

2Nuffield College, University of Oxford, Oxford, United Kingdom

3École Nationale de la Statistique et de L’administration Économique (ENSAE), Paris, France

4Center for Research in Economics and Statistics (CREST), Paris, France

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David M. Brazel

1Leverhulme Centre for Demographic Science, University of Oxford, Oxford, United Kingdom

2Nuffield College, University of Oxford, Oxford, United Kingdom

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Natalie van Zuydam

5The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden

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Ahmad Vaez

6Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

7Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran

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Tune H. Pers

8The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

9Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

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Harold Snieder

6Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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John R.B. Perry

10MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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Ken K. Ong

10MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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Marcel den Hoed

5The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden

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Nicola Barban

11Institute of Social and Economic Research, University of Essex, Essex, United Kingdom

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Felix R. Day

10MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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For correspondence: melinda.mills@nuffield.ox.ac.uk felix.day@mrc-epid.cam.ac.uk

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Identification of 370 loci for age at onset of sexual and reproductive behaviour, highlighting common aetiology with reproductive biology, externalizing behaviour and longevity

Melinda C. Mills, Felix C. Tropf, David M. Brazel, Natalie van Zuydam, Ahmad Vaez, eQTLGen Consortium, BIOS Consortium, Tune H. Pers, Harold Snieder, John R.B. Perry, Ken K. Ong, Marcel den Hoed, Nicola Barban, Felix R. Day, on behalf of the Human Reproductive Behaviour Consortium

bioRxiv 2020.05.06.081273; doi: https://doi.org/10.1101/2020.05.06.081273

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Identification of 370 loci for age at onset of sexual and reproductive behaviour, highlighting common aetiology with reproductive biology, externalizing behaviour and longevity

bioRxiv 2020.05.06.081273; doi: https://doi.org/10.1101/2020.05.06.081273

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