Abstract
The incidence of Cystic fibrosis (CF) and the frequency of the variants for CFTR depend on the population; furthermore, CF symptomatology is characterized by obstructive lung disease, pancreatic insufficiency among others, reliant on the individual genotype. Ecuadorian population is a mixture of Native Americans, Europeans, and Africans. That population admixture could be the reason for the new mutations reported in a previous study by Ruiz et al. (2019). A panel of 46 Ancestry Informative Markers was used to estimate the ancestral proportions of each available sample (12 samples in total). As a result, the Native American ancestry proportion was the most prevalent in almost all individuals, except for three patients from Guayaquil with the mutation [c.757G>A:p.Gly253Arg; c.1352G>T:p.Gly451Val] who had the highest European composition.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
César Paz-y-Miño: cesar.pazymino{at}ute.edu.ec Ana Karina Zambrano: anazambrano17{at}hotmail.com Juan Carlos Ruiz-Cabezas: jcruizc{at}hotmail.com Isaac Armendáriz-Castillo: fabian.armendariz{at}ute.edu.ec Jennyfer García-Cárdenas: jennyfer.garcia{at}ute.edu.ec Santiago Guerrero: santiago.guerrero{at}ute.edu.ec Andrés López-Cortés: andresa.lopez{at}ute.edu.ec Andy Pérez-Villa: andy.perez{at}ute.edu.ec Patricia Guevara-Ramírez: alexandra.guevara{at}ute.edu.ec Verónica Yumiceba: veronica.yumiceba{at}ute.edu.ec Paola E. Leone: paola.leone{at}ute.edu.ec