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Werewolf, there wolf: variants in Hairless associated with hypotrichia and roaning in the lykoi cat breed

Reuben M. Buckley, Barbara Gandolfi, Erica K. Creighton, Connor A. Pyne, Michelle L. LeRoy, David A. Senter, Delia M. Bouhan, Johnny R. Gobble, Marie Abitbol, View ORCID ProfileLeslie A. Lyons, 99 Lives Consortium
doi: https://doi.org/10.1101/2020.05.07.082719
Reuben M. Buckley
1Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
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Barbara Gandolfi
1Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
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Erica K. Creighton
1Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
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Connor A. Pyne
1Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
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Michelle L. LeRoy
1Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
2Veterinary Allergy and Dermatology Clinic, LLC., Overland Park, KS 66210 USA
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David A. Senter
1Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
2Veterinary Allergy and Dermatology Clinic, LLC., Overland Park, KS 66210 USA
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Delia M. Bouhan
1Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
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Johnny R. Gobble
3Tellico Bay Animal Hospital, Vonore, TN 37885 USA
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Marie Abitbol
4NeuroMyoGène Institute, CNRS UMR5310, INSERM U1217, Faculty of Medicine, Rockefeller, Claude Bernard Lyon I University, Lyon, France
5Univ Lyon, VetAgro Sup, Marcy-l’Etoile, France
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Leslie A. Lyons
1Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
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  • ORCID record for Leslie A. Lyons
  • For correspondence: lyonsla@missouri.edu
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Abstract

A variety of cat breeds have been developed via novelty selection on aesthetic, dermatological traits, such as coat colors and fur types. A recently developed breed, the lykoi, was bred from cats with a sparse hair coat with roaning, implying full color and all white hairs. The lykoi phenotype is a form of hypotrichia, presenting as significant reduction in the average numbers of follicles per hair follicle group as compared to domestic shorthair cats, a mild to severe perifollicular to mural lymphocytic infiltration in 77% of observed hair follicle groups, and the follicles are often miniaturized, dilated, and dysplastic. Whole genome sequencing was conducted on a single lykoi cat that was a cross between two independently ascertained lineages. Comparison to the 99 Lives dataset of 194 non-lykoi cats suggested two variants in the cat homolog for Hairless (HR: lysine demethylase and nuclear receptor corepressor) as candidate causal variants. The lykoi cat was a compound heterozygote for two loss of function variants in HR, an exon 3 c.1255_1256dupGT (chrB1:36040783), which should produce a stop codon at amino acid 420 (p.Gln420Serfs*100) and, an exon 18 c.3389insGACA (chrB1:36051555), which should produce a stop codon at amino acid position 1130 (p.Ser1130Argfs*29). Ascertainment of 14 additional cats from founder lineages from Canada, France and different areas of the USA identified four additional loss of function HR variants likely causing the highly similar phenotypic hair coat across the diverse cats. The novel variants in HR for cat hypotrichia can now be established between minor differences in the phenotypic presentations.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Werewolf, there wolf: variants in Hairless associated with hypotrichia and roaning in the lykoi cat breed
Reuben M. Buckley, Barbara Gandolfi, Erica K. Creighton, Connor A. Pyne, Michelle L. LeRoy, David A. Senter, Delia M. Bouhan, Johnny R. Gobble, Marie Abitbol, Leslie A. Lyons, 99 Lives Consortium
bioRxiv 2020.05.07.082719; doi: https://doi.org/10.1101/2020.05.07.082719
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Werewolf, there wolf: variants in Hairless associated with hypotrichia and roaning in the lykoi cat breed
Reuben M. Buckley, Barbara Gandolfi, Erica K. Creighton, Connor A. Pyne, Michelle L. LeRoy, David A. Senter, Delia M. Bouhan, Johnny R. Gobble, Marie Abitbol, Leslie A. Lyons, 99 Lives Consortium
bioRxiv 2020.05.07.082719; doi: https://doi.org/10.1101/2020.05.07.082719

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