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Reversing age: dual species measurement of epigenetic age with a single clock

View ORCID ProfileSteve Horvath, Kavita Singh, Ken Raj, Shraddha Khairnar, Akshay Sanghavi, Agnivesh Shrivastava, Joseph A. Zoller, Caesar Z. Li, Claudia B. Herenu, Martina Canatelli-Mallat, Marianne Lehmann, Leah C. Solberg Woods, Angel Garcia Martinez, Tengfei Wang, Priscila Chiavellini, Andrew J. Levine, Hao Chen, Rodolfo G. Goya, Harold L. Katcher
doi: https://doi.org/10.1101/2020.05.07.082917
Steve Horvath
1Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
2Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, USA
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  • For correspondence: shorvath@mednet.ucla.edu harold@nugenicsresearch.com
Kavita Singh
3Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS University, Mumbai, India
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Ken Raj
4Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, UK
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Shraddha Khairnar
3Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS University, Mumbai, India
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Akshay Sanghavi
5Nugenics Research Pvt Ltd, India
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Agnivesh Shrivastava
5Nugenics Research Pvt Ltd, India
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Joseph A. Zoller
2Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, USA
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Caesar Z. Li
2Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, USA
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Claudia B. Herenu
6Institute for Experimental Pharmacology of Cordoba (IFEC), School of Chemical Sciences, National University of Cordoba, Cordoba, Argentina
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Martina Canatelli-Mallat
7Biochemistry Research Institute of La Plata – Histology B, Pathology B, School of Medicine, University of La Plata, La Plata CC 455 (zip 1900), Argentina
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Marianne Lehmann
7Biochemistry Research Institute of La Plata – Histology B, Pathology B, School of Medicine, University of La Plata, La Plata CC 455 (zip 1900), Argentina
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Leah C. Solberg Woods
8Wake Forest University School of Medicine, 1 Medical Center Drive, Winston Salem, NC 27157, USA
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Angel Garcia Martinez
9Department of Pharmacology, Addiction Science and Toxicology, The University of Tennessee Health Science Center, Memphis, TN 3993, USA
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Tengfei Wang
9Department of Pharmacology, Addiction Science and Toxicology, The University of Tennessee Health Science Center, Memphis, TN 3993, USA
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Priscila Chiavellini
7Biochemistry Research Institute of La Plata – Histology B, Pathology B, School of Medicine, University of La Plata, La Plata CC 455 (zip 1900), Argentina
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Andrew J. Levine
10Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA, 90095, USA
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Hao Chen
9Department of Pharmacology, Addiction Science and Toxicology, The University of Tennessee Health Science Center, Memphis, TN 3993, USA
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Rodolfo G. Goya
7Biochemistry Research Institute of La Plata – Histology B, Pathology B, School of Medicine, University of La Plata, La Plata CC 455 (zip 1900), Argentina
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Harold L. Katcher
5Nugenics Research Pvt Ltd, India
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  • For correspondence: shorvath@mednet.ucla.edu harold@nugenicsresearch.com
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Article Information

doi 
https://doi.org/10.1101/2020.05.07.082917
History 
  • May 8, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Steve Horvath1,2,#,*,
  2. Kavita Singh3,#,
  3. Ken Raj4,#,
  4. Shraddha Khairnar3,
  5. Akshay Sanghavi5,
  6. Agnivesh Shrivastava5,
  7. Joseph A. Zoller2,
  8. Caesar Z. Li2,
  9. Claudia B. Herenu6,
  10. Martina Canatelli-Mallat7,
  11. Marianne Lehmann7,
  12. Leah C. Solberg Woods8,
  13. Angel Garcia Martinez9,
  14. Tengfei Wang9,
  15. Priscila Chiavellini7,
  16. Andrew J. Levine10,
  17. Hao Chen9,
  18. Rodolfo G. Goya7 and
  19. Harold L. Katcher5,*
  1. 1Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
  2. 2Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, USA
  3. 3Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS University, Mumbai, India
  4. 4Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, UK
  5. 5Nugenics Research Pvt Ltd, India
  6. 6Institute for Experimental Pharmacology of Cordoba (IFEC), School of Chemical Sciences, National University of Cordoba, Cordoba, Argentina
  7. 7Biochemistry Research Institute of La Plata – Histology B, Pathology B, School of Medicine, University of La Plata, La Plata CC 455 (zip 1900), Argentina
  8. 8Wake Forest University School of Medicine, 1 Medical Center Drive, Winston Salem, NC 27157, USA
  9. 9Department of Pharmacology, Addiction Science and Toxicology, The University of Tennessee Health Science Center, Memphis, TN 3993, USA
  10. 10Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA, 90095, USA
  1. ↵*Correspondence: Steve Horvath E-mail: shorvath{at}mednet.ucla.edu Address: Gonda Building, 695 Charles Young Drive South, Los Angeles, CA 90095, Harold Katcher E-mail: harold{at}nugenicsresearch.com
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Reversing age: dual species measurement of epigenetic age with a single clock
Steve Horvath, Kavita Singh, Ken Raj, Shraddha Khairnar, Akshay Sanghavi, Agnivesh Shrivastava, Joseph A. Zoller, Caesar Z. Li, Claudia B. Herenu, Martina Canatelli-Mallat, Marianne Lehmann, Leah C. Solberg Woods, Angel Garcia Martinez, Tengfei Wang, Priscila Chiavellini, Andrew J. Levine, Hao Chen, Rodolfo G. Goya, Harold L. Katcher
bioRxiv 2020.05.07.082917; doi: https://doi.org/10.1101/2020.05.07.082917
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Reversing age: dual species measurement of epigenetic age with a single clock
Steve Horvath, Kavita Singh, Ken Raj, Shraddha Khairnar, Akshay Sanghavi, Agnivesh Shrivastava, Joseph A. Zoller, Caesar Z. Li, Claudia B. Herenu, Martina Canatelli-Mallat, Marianne Lehmann, Leah C. Solberg Woods, Angel Garcia Martinez, Tengfei Wang, Priscila Chiavellini, Andrew J. Levine, Hao Chen, Rodolfo G. Goya, Harold L. Katcher
bioRxiv 2020.05.07.082917; doi: https://doi.org/10.1101/2020.05.07.082917

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