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Typical and atypical language brain organization based on intrinsic connectivity and multitask functional asymmetries

View ORCID ProfileLoïc Labache, View ORCID ProfileBernard Mazoyer, View ORCID ProfileMarc Joliot, View ORCID ProfileFabrice Crivello, View ORCID ProfileIsabelle Hesling, View ORCID ProfileNathalie Tzourio-Mazoyer
doi: https://doi.org/10.1101/2020.05.07.083006
Loïc Labache
1Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
2CNRS, Institut des Maladies Neurodégéneratives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
3CEA, Institut des Maladies Neurodégéneratives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
4Université de Bordeaux, Institut de Mathématiques de Bordeaux, UMR 5251, F-33000 Bordeaux
5Bordeaux INP, Institut de Mathématiques de Bordeaux, UMR 5251, F-33000 Bordeaux
6INRIA Bordeaux Sud-Ouest, Institut de Mathématiques de Bordeaux, UMR 5251, Contrôle de Qualité et Fiabilité Dynamique, F-33405 Talence, France
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Bernard Mazoyer
1Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
2CNRS, Institut des Maladies Neurodégéneratives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
3CEA, Institut des Maladies Neurodégéneratives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
7Centre Hospitalier Universitaire de Bordeaux, F-33076 Bordeaux, France
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  • For correspondence: bernard.mazoyer@u-bordeaux.fr
Marc Joliot
1Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
2CNRS, Institut des Maladies Neurodégéneratives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
3CEA, Institut des Maladies Neurodégéneratives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
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Fabrice Crivello
1Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
2CNRS, Institut des Maladies Neurodégéneratives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
3CEA, Institut des Maladies Neurodégéneratives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
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Isabelle Hesling
1Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
2CNRS, Institut des Maladies Neurodégéneratives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
3CEA, Institut des Maladies Neurodégéneratives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
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Nathalie Tzourio-Mazoyer
1Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
2CNRS, Institut des Maladies Neurodégéneratives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
3CEA, Institut des Maladies Neurodégéneratives, UMR 5293, Groupe d’Imagerie Neurofonctionnelle, F-33000 Bordeaux, France
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ABSTRACT

Based on the joint investigation in 287 healthy volunteers (150 Left-Handers (LH)) of language task-induced asymmetries and intrinsic connectivity strength of the sentence-processing supramodal network, we show that individuals with atypical rightward language lateralization (N = 30, 25 LH) do not rely on an organization that simply mirrors that of typical leftward lateralized individuals. Actually, the resting-state organization in the atypicals showed that their sentence processing was underpinned by left and right networks both wired for language processing and highly interacting by strong interhemispheric intrinsic connectivity and larger corpus callosum volume. Such a loose hemispheric specialization for language permits the hosting of language in either the left and/or right hemisphere as assessed by a very high incidence of dissociations across various language task-induced asymmetries in this group.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Reviewers revisions.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 10, 2020.
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Typical and atypical language brain organization based on intrinsic connectivity and multitask functional asymmetries
Loïc Labache, Bernard Mazoyer, Marc Joliot, Fabrice Crivello, Isabelle Hesling, Nathalie Tzourio-Mazoyer
bioRxiv 2020.05.07.083006; doi: https://doi.org/10.1101/2020.05.07.083006
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Typical and atypical language brain organization based on intrinsic connectivity and multitask functional asymmetries
Loïc Labache, Bernard Mazoyer, Marc Joliot, Fabrice Crivello, Isabelle Hesling, Nathalie Tzourio-Mazoyer
bioRxiv 2020.05.07.083006; doi: https://doi.org/10.1101/2020.05.07.083006

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