Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Ray tracing models for estimating light collection properties of microstructured tapered optical fibers for optical neural interfaces

Emanuela Maglie, Marco Pisanello, View ORCID ProfileFilippo Pisano, Antonio Balena, Marco Bianco, Barbara Spagnolo, Leonardo Sileo, View ORCID ProfileBernardo L. Sabatini, View ORCID ProfileMassimo De Vittorio, View ORCID ProfileFerruccio Pisanello
doi: https://doi.org/10.1101/2020.05.07.083469
Emanuela Maglie
1Fondazione Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnologies, Arnesano (LE), 73100, Italy
2Dipartimento di Ingegneria Dell’Innovazione, Università del Salento, Lecce, 73100, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marco Pisanello
1Fondazione Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnologies, Arnesano (LE), 73100, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Filippo Pisano
1Fondazione Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnologies, Arnesano (LE), 73100, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Filippo Pisano
Antonio Balena
1Fondazione Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnologies, Arnesano (LE), 73100, Italy
2Dipartimento di Ingegneria Dell’Innovazione, Università del Salento, Lecce, 73100, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marco Bianco
1Fondazione Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnologies, Arnesano (LE), 73100, Italy
2Dipartimento di Ingegneria Dell’Innovazione, Università del Salento, Lecce, 73100, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Barbara Spagnolo
1Fondazione Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnologies, Arnesano (LE), 73100, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leonardo Sileo
1Fondazione Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnologies, Arnesano (LE), 73100, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bernardo L. Sabatini
3Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 0211
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Bernardo L. Sabatini
Massimo De Vittorio
1Fondazione Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnologies, Arnesano (LE), 73100, Italy
2Dipartimento di Ingegneria Dell’Innovazione, Università del Salento, Lecce, 73100, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Massimo De Vittorio
Ferruccio Pisanello
1Fondazione Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnologies, Arnesano (LE), 73100, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ferruccio Pisanello
  • For correspondence: ferruccio.pisanello@iit.it
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

ABSTRACT

Tapered optical fibers (TFs) were recently employed for depth-resolved monitoring of functional fluorescence in sub-cortical brain structures, enabling light collection from groups of a few cells through small optical windows located on the taper edge [1]. Here we present a numerical model to estimate light collection properties of microstructured TFs implanted in scattering brain tissue. Ray tracing coupled with Henyey-Greenstein scattering model enables the estimation of both light collection and fluorescence excitation fields in three dimensions, whose combination is employed to retrieve the volume of tissue probed by the device.

Competing Interest Statement

L.S., B.L.S., M.D.V. and F. Pisanello are founders and hold private equity in Optogenix, a company that develops, produces and sells technologiesto deliver light into the brain. Tapered fibers commercially available from Optogenix were used as tools in the research.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted May 10, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Ray tracing models for estimating light collection properties of microstructured tapered optical fibers for optical neural interfaces
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Ray tracing models for estimating light collection properties of microstructured tapered optical fibers for optical neural interfaces
Emanuela Maglie, Marco Pisanello, Filippo Pisano, Antonio Balena, Marco Bianco, Barbara Spagnolo, Leonardo Sileo, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello
bioRxiv 2020.05.07.083469; doi: https://doi.org/10.1101/2020.05.07.083469
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Ray tracing models for estimating light collection properties of microstructured tapered optical fibers for optical neural interfaces
Emanuela Maglie, Marco Pisanello, Filippo Pisano, Antonio Balena, Marco Bianco, Barbara Spagnolo, Leonardo Sileo, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello
bioRxiv 2020.05.07.083469; doi: https://doi.org/10.1101/2020.05.07.083469

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Bioengineering
Subject Areas
All Articles
  • Animal Behavior and Cognition (4116)
  • Biochemistry (8820)
  • Bioengineering (6523)
  • Bioinformatics (23470)
  • Biophysics (11798)
  • Cancer Biology (9216)
  • Cell Biology (13327)
  • Clinical Trials (138)
  • Developmental Biology (7440)
  • Ecology (11417)
  • Epidemiology (2066)
  • Evolutionary Biology (15160)
  • Genetics (10442)
  • Genomics (14051)
  • Immunology (9176)
  • Microbiology (22170)
  • Molecular Biology (8817)
  • Neuroscience (47600)
  • Paleontology (350)
  • Pathology (1429)
  • Pharmacology and Toxicology (2492)
  • Physiology (3733)
  • Plant Biology (8084)
  • Scientific Communication and Education (1437)
  • Synthetic Biology (2221)
  • Systems Biology (6039)
  • Zoology (1254)