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Brief sensory deprivation triggers cell type-specific structural and functional plasticity in olfactory bulb neurons

View ORCID ProfileElisa Galliano, Christiane Hahn, View ORCID ProfileLorcan Browne, Paula R. Villamayor, View ORCID ProfileMatthew S. Grubb
doi: https://doi.org/10.1101/2020.05.10.086926
Elisa Galliano
1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK
2Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
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  • For correspondence: eg542@cam.ac.uk matthew.grubb@kcl.ac.uk
Christiane Hahn
1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK
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Lorcan Browne
1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK
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Paula R. Villamayor
1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK
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Matthew S. Grubb
1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK
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  • For correspondence: eg542@cam.ac.uk matthew.grubb@kcl.ac.uk
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ABSTRACT

Can alterations in experience trigger different plastic modifications in neuronal structure and function, and if so, how do they integrate at the cellular level? To address this question, we interrogated circuitry in the mouse olfactory bulb responsible for the earliest steps in odour processing. We induced experience-dependent plasticity in mice by blocking one nostril for a day, a minimally-invasive manipulation which leaves the sensory organ undamaged and is akin to the natural transient blockage suffered during common mild rhinal infections. We found that such brief sensory deprivation produced structural and functional plasticity in one highly specialised bulbar cell type: axon-bearing dopaminergic neurons in the glomerular layer. After 24h naris occlusion, the axon initial segment (AIS) in bulbar dopaminergic neurons became significantly shorter, a structural modification that was also associated with a decrease in intrinsic excitability. These effects were specific to the AIS-positive dopaminergic subpopulation, because no experience-dependent alterations in intrinsic excitability were observed in AIS-negative dopaminergic cells. Moreover, 24h naris occlusion produced no structural changes at the AIS of bulbar excitatory neurons – mitral/tufted and external tufted cells – nor did it alter their intrinsic excitability. By targeting excitability in one specialised dopaminergic subpopulation, experience-dependent plasticity in early olfactory networks might act to fine-tune sensory processing in the face of continually fluctuating inputs.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted May 12, 2020.
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Brief sensory deprivation triggers cell type-specific structural and functional plasticity in olfactory bulb neurons
Elisa Galliano, Christiane Hahn, Lorcan Browne, Paula R. Villamayor, Matthew S. Grubb
bioRxiv 2020.05.10.086926; doi: https://doi.org/10.1101/2020.05.10.086926
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Brief sensory deprivation triggers cell type-specific structural and functional plasticity in olfactory bulb neurons
Elisa Galliano, Christiane Hahn, Lorcan Browne, Paula R. Villamayor, Matthew S. Grubb
bioRxiv 2020.05.10.086926; doi: https://doi.org/10.1101/2020.05.10.086926

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