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Fast recurrent processing via ventral prefrontal cortex is needed by the primate ventral stream for robust core visual object recognition

View ORCID ProfileKohitij Kar, View ORCID ProfileJames J DiCarlo
doi: https://doi.org/10.1101/2020.05.10.086959
Kohitij Kar
1McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 01239, USA
2Center for Brains, Minds, and Machines, Massachusetts Institute of Technology, Cambridge, MA, 01239, USA
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  • For correspondence: kohitij@mit.edu
James J DiCarlo
1McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 01239, USA
2Center for Brains, Minds, and Machines, Massachusetts Institute of Technology, Cambridge, MA, 01239, USA
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Summary

Distributed neural population spiking patterns in macaque inferior temporal (IT) cortex that support core visual object recognition require additional time to develop for specific (“late-solved”) images suggesting the necessity of recurrent processing in these computations. Which brain circuit motifs are most responsible for computing and transmitting these putative recurrent signals to IT? To test whether the ventral prefrontal cortex (vPFC) is a critical recurrent circuit node in this system, here we pharmacologically inactivated parts of the vPFC and simultaneously measured IT population activity, while monkeys performed object discrimination tasks. Our results show that vPFC inactivation deteriorated the quality of the late-phase (>150 ms from image onset) IT population code, along with commensurate, specific behavioral deficits for “late-solved” images. Finally, silencing vPFC caused the monkeys’ IT activity patterns and behavior to become more like those produced by feedforward artificial neural network models of the ventral stream. Together with prior work, these results argue that fast recurrent processing through the vPFC is critical to the production of behaviorally-sufficient object representations in IT.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 12, 2020.
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Fast recurrent processing via ventral prefrontal cortex is needed by the primate ventral stream for robust core visual object recognition
Kohitij Kar, James J DiCarlo
bioRxiv 2020.05.10.086959; doi: https://doi.org/10.1101/2020.05.10.086959
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Fast recurrent processing via ventral prefrontal cortex is needed by the primate ventral stream for robust core visual object recognition
Kohitij Kar, James J DiCarlo
bioRxiv 2020.05.10.086959; doi: https://doi.org/10.1101/2020.05.10.086959

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