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Low doses of radiation therapy increase the immunosuppressive profile of lung macrophages via IL-10 production and IFNγ/IL-6 suppression: a therapeutic strategy to counteract lung inflammation?

View ORCID ProfileLydia Meziani, Charlotte Robert, Pierre Mordant, Eric Deutsch
doi: https://doi.org/10.1101/2020.05.11.077651
Lydia Meziani
1INSERM U1030, Radiothérapie Moléculaire et Innovations Thérapetuiques, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France
2Labex LERMIT, DHU TORINO, SIRIC SOCRATE
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  • ORCID record for Lydia Meziani
Charlotte Robert
1INSERM U1030, Radiothérapie Moléculaire et Innovations Thérapetuiques, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France
2Labex LERMIT, DHU TORINO, SIRIC SOCRATE
3Department of Radiation Oncology, Gustave Roussy Cancer Campus, Villejuif, France
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Pierre Mordant
4Department of vascular surgery, thoracic surgery, and lung transplantation, Bichat Hospital, Assistance Publique – Hôpitaux de Paris, INSERM U1152, Université de Paris, Paris, France
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Eric Deutsch
1INSERM U1030, Radiothérapie Moléculaire et Innovations Thérapetuiques, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France
2Labex LERMIT, DHU TORINO, SIRIC SOCRATE
3Department of Radiation Oncology, Gustave Roussy Cancer Campus, Villejuif, France
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  • For correspondence: eric.deutsch@gustaveroussy.fr lydia.meziani@gustaveroussy.fr
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Article Information

doi 
https://doi.org/10.1101/2020.05.11.077651
History 
  • May 13, 2020.

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  • You are currently viewing Version 1 of this article (May 13, 2020 - 15:42).
  • View Version 2, the most recent version of this article.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Lydia Meziani1,2,
  2. Charlotte Robert1,2,3,
  3. Pierre Mordant4 and
  4. Eric Deutsch1,2,3,*
  1. 1INSERM U1030, Radiothérapie Moléculaire et Innovations Thérapetuiques, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France
  2. 2Labex LERMIT, DHU TORINO, SIRIC SOCRATE
  3. 3Department of Radiation Oncology, Gustave Roussy Cancer Campus, Villejuif, France
  4. 4Department of vascular surgery, thoracic surgery, and lung transplantation, Bichat Hospital, Assistance Publique – Hôpitaux de Paris, INSERM U1152, Université de Paris, Paris, France
  1. ↵*Corresponding authors: Eric Deutsch and Lydia Meziani, Gustave Roussy, INSERM U1030, 114 rue Edouard Vaillant; 94805 Villejuif, France; eric.deutsch{at}gustaveroussy.fr, lydia.meziani{at}gustaveroussy.fr
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Posted May 13, 2020.
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Low doses of radiation therapy increase the immunosuppressive profile of lung macrophages via IL-10 production and IFNγ/IL-6 suppression: a therapeutic strategy to counteract lung inflammation?
Lydia Meziani, Charlotte Robert, Pierre Mordant, Eric Deutsch
bioRxiv 2020.05.11.077651; doi: https://doi.org/10.1101/2020.05.11.077651
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Low doses of radiation therapy increase the immunosuppressive profile of lung macrophages via IL-10 production and IFNγ/IL-6 suppression: a therapeutic strategy to counteract lung inflammation?
Lydia Meziani, Charlotte Robert, Pierre Mordant, Eric Deutsch
bioRxiv 2020.05.11.077651; doi: https://doi.org/10.1101/2020.05.11.077651

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