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Evidence for strong mutation bias towards, and selection against, T/U content in SARS-CoV2: implications for attenuated vaccine design
View ORCID ProfileAlan M. Rice, View ORCID ProfileAtahualpa Castillo Morales, Alexander T. Ho, View ORCID ProfileChristine Mordstein, View ORCID ProfileStefanie Mühlhausen, View ORCID ProfileSamir Watson, Laura Cano, Bethan Young, View ORCID ProfileGrzegorz Kudla, View ORCID ProfileLaurence D. Hurst
doi: https://doi.org/10.1101/2020.05.11.088112
Alan M. Rice
1The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
Atahualpa Castillo Morales
1The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
Alexander T. Ho
1The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
Christine Mordstein
1The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
2MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK
Stefanie Mühlhausen
1The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
Samir Watson
3Aarhus University, Department of Molecular Biology and Genetics, C F MøllersAllé 3, 8000 Aarhus, Denmark
Laura Cano
2MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK
Bethan Young
1The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
2MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK
Grzegorz Kudla
2MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK
Laurence D. Hurst
1The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
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Posted May 11, 2020.
Evidence for strong mutation bias towards, and selection against, T/U content in SARS-CoV2: implications for attenuated vaccine design
Alan M. Rice, Atahualpa Castillo Morales, Alexander T. Ho, Christine Mordstein, Stefanie Mühlhausen, Samir Watson, Laura Cano, Bethan Young, Grzegorz Kudla, Laurence D. Hurst
bioRxiv 2020.05.11.088112; doi: https://doi.org/10.1101/2020.05.11.088112
Evidence for strong mutation bias towards, and selection against, T/U content in SARS-CoV2: implications for attenuated vaccine design
Alan M. Rice, Atahualpa Castillo Morales, Alexander T. Ho, Christine Mordstein, Stefanie Mühlhausen, Samir Watson, Laura Cano, Bethan Young, Grzegorz Kudla, Laurence D. Hurst
bioRxiv 2020.05.11.088112; doi: https://doi.org/10.1101/2020.05.11.088112
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