Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients

Liqun He, Maarja Andaloussi Mäe, Ying Sun, Lars Muhl, Khayrun Nahar, Elisa Vázquez Liébanas, Malin Jonsson Fagerlund, Anders Oldner, Jianping Liu, Guillem Genové, Riikka Pietilä, Lei Zhang, Yuan Xie, Stefanos Leptidis, Guiseppe Mocci, Simon Stritt, Ahmed Osman, Andrey Anisimov, Karthik Amudhala Hemanthakumar, Markus Räsenen, Johan Björkegren, Michael Vanlandewijck, Klas Blomgren, Emil Hansson, Taija Mäkinen, Xiao-Rong Peng, Thomas D. Arnold, Kari Alitalo, Lars I Eriksson, Urban Lendahl, Christer Betsholtz
doi: https://doi.org/10.1101/2020.05.11.088500
Liqun He
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maarja Andaloussi Mäe
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ying Sun
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lars Muhl
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Khayrun Nahar
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elisa Vázquez Liébanas
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Malin Jonsson Fagerlund
3Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Solna and Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anders Oldner
3Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Solna and Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jianping Liu
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Guillem Genové
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Riikka Pietilä
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lei Zhang
4Key Laboratory of Ministry of Education for Medicinal Plant Resource and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuan Xie
4Key Laboratory of Ministry of Education for Medicinal Plant Resource and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stefanos Leptidis
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Guiseppe Mocci
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Simon Stritt
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ahmed Osman
5Department of Women’s and Children’s Health, Karolinska Institutet, Solna, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrey Anisimov
6Wihuri Research Institute and Translational Cancer Medicine Program, Biomedicum Helsinki, University of Helsinki, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karthik Amudhala Hemanthakumar
6Wihuri Research Institute and Translational Cancer Medicine Program, Biomedicum Helsinki, University of Helsinki, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Markus Räsenen
6Wihuri Research Institute and Translational Cancer Medicine Program, Biomedicum Helsinki, University of Helsinki, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Johan Björkegren
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
7Institute of Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
8Department of Pathophysiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
9Clinical Gene Networks AB, Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Vanlandewijck
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Klas Blomgren
5Department of Women’s and Children’s Health, Karolinska Institutet, Solna, Sweden
10Cardiovascular, Renal and Metabolism (CVRM), IMED Biotech Unit, AstraZeneca BioPharmaceuticals R&D, Gothenburg, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emil Hansson
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Taija Mäkinen
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiao-Rong Peng
11Department of Pediatric oncology, Karolinska University Hospital, Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas D. Arnold
12Department of Pediatrics, University of California San Francisco, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kari Alitalo
6Wihuri Research Institute and Translational Cancer Medicine Program, Biomedicum Helsinki, University of Helsinki, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lars I Eriksson
3Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Solna and Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Urban Lendahl
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
13Department of Cell and Molecular Biology, Karolinska Institutet, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christer Betsholtz
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
14Department of Medicine Huddinge, Karolinska Institutet, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: christer.betsholtz@ki.se christer.betsholtz@igp.uu.se
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Article Information

doi 
https://doi.org/10.1101/2020.05.11.088500
History 
  • May 12, 2020.

Article Versions

  • You are currently viewing Version 1 of this article (May 12, 2020 - 14:44).
  • View Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Liqun He1,*,
  2. Maarja Andaloussi Mäe1,*,
  3. Ying Sun1,
  4. Lars Muhl2,
  5. Khayrun Nahar1,
  6. Elisa Vázquez Liébanas1,
  7. Malin Jonsson Fagerlund3,
  8. Anders Oldner3,
  9. Jianping Liu2,
  10. Guillem Genové2,
  11. Riikka Pietilä1,
  12. Lei Zhang4,
  13. Yuan Xie4,
  14. Stefanos Leptidis2,
  15. Guiseppe Mocci2,
  16. Simon Stritt1,
  17. Ahmed Osman5,
  18. Andrey Anisimov6,
  19. Karthik Amudhala Hemanthakumar6,
  20. Markus Räsenen6,
  21. Johan Björkegren2,7,8,9,
  22. Michael Vanlandewijck2,
  23. Klas Blomgren5,10,
  24. Emil Hansson2,
  25. Taija Mäkinen1,
  26. Xiao-Rong Peng11,
  27. Thomas D. Arnold12,
  28. Kari Alitalo6,
  29. Lars I Eriksson3,
  30. Urban Lendahl2,13 and
  31. Christer Betsholtz1,2,14,§
  1. 1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  2. 2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
  3. 3Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Solna and Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
  4. 4Key Laboratory of Ministry of Education for Medicinal Plant Resource and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, China
  5. 5Department of Women’s and Children’s Health, Karolinska Institutet, Solna, Sweden
  6. 6Wihuri Research Institute and Translational Cancer Medicine Program, Biomedicum Helsinki, University of Helsinki, Finland
  7. 7Institute of Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
  8. 8Department of Pathophysiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
  9. 9Clinical Gene Networks AB, Stockholm, Sweden
  10. 10Cardiovascular, Renal and Metabolism (CVRM), IMED Biotech Unit, AstraZeneca BioPharmaceuticals R&D, Gothenburg, Sweden
  11. 11Department of Pediatric oncology, Karolinska University Hospital, Stockholm, Sweden
  12. 12Department of Pediatrics, University of California San Francisco, USA
  13. 13Department of Cell and Molecular Biology, Karolinska Institutet, Sweden
  14. 14Department of Medicine Huddinge, Karolinska Institutet, Sweden
  1. ↵§Correspondence: christer.betsholtz{at}ki.se or christer.betsholtz{at}igp.uu.se
  1. ↵* Shared contribution

Back to top
PreviousNext
Posted May 12, 2020.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients
Liqun He, Maarja Andaloussi Mäe, Ying Sun, Lars Muhl, Khayrun Nahar, Elisa Vázquez Liébanas, Malin Jonsson Fagerlund, Anders Oldner, Jianping Liu, Guillem Genové, Riikka Pietilä, Lei Zhang, Yuan Xie, Stefanos Leptidis, Guiseppe Mocci, Simon Stritt, Ahmed Osman, Andrey Anisimov, Karthik Amudhala Hemanthakumar, Markus Räsenen, Johan Björkegren, Michael Vanlandewijck, Klas Blomgren, Emil Hansson, Taija Mäkinen, Xiao-Rong Peng, Thomas D. Arnold, Kari Alitalo, Lars I Eriksson, Urban Lendahl, Christer Betsholtz
bioRxiv 2020.05.11.088500; doi: https://doi.org/10.1101/2020.05.11.088500
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients
Liqun He, Maarja Andaloussi Mäe, Ying Sun, Lars Muhl, Khayrun Nahar, Elisa Vázquez Liébanas, Malin Jonsson Fagerlund, Anders Oldner, Jianping Liu, Guillem Genové, Riikka Pietilä, Lei Zhang, Yuan Xie, Stefanos Leptidis, Guiseppe Mocci, Simon Stritt, Ahmed Osman, Andrey Anisimov, Karthik Amudhala Hemanthakumar, Markus Räsenen, Johan Björkegren, Michael Vanlandewijck, Klas Blomgren, Emil Hansson, Taija Mäkinen, Xiao-Rong Peng, Thomas D. Arnold, Kari Alitalo, Lars I Eriksson, Urban Lendahl, Christer Betsholtz
bioRxiv 2020.05.11.088500; doi: https://doi.org/10.1101/2020.05.11.088500

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Pathology
Subject Areas
All Articles
  • Animal Behavior and Cognition (2652)
  • Biochemistry (5282)
  • Bioengineering (3695)
  • Bioinformatics (15822)
  • Biophysics (7278)
  • Cancer Biology (5633)
  • Cell Biology (8116)
  • Clinical Trials (138)
  • Developmental Biology (4780)
  • Ecology (7544)
  • Epidemiology (2059)
  • Evolutionary Biology (10600)
  • Genetics (7745)
  • Genomics (10157)
  • Immunology (5221)
  • Microbiology (13958)
  • Molecular Biology (5398)
  • Neuroscience (30852)
  • Paleontology (217)
  • Pathology (883)
  • Pharmacology and Toxicology (1527)
  • Physiology (2262)
  • Plant Biology (5033)
  • Scientific Communication and Education (1044)
  • Synthetic Biology (1399)
  • Systems Biology (4155)
  • Zoology (814)